Search Results - "Mehrkens, D"

Olfactory receptor 2 deficiency protects from experimental abdominal aortic aneurysm formation by Schelemei, P., Picard, F., Nemade, H., Mehrkens, D., Grimm, S., Tinaz, K., Wagner, E., Kreuzberg, W., Orecchioni, M., Wagenhäuser, M., Schelzig, H., Roy, J., Liljeqvist, M., Mollenhauer, M., Baldus, S., Winkels, H.

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4D strain analysis in murine echocardiography facilitates quantification of myocardial infarction by Schreiber, C, Ballmann, F S, Mehrkens, D, Geissen, S

“…Abstract Introduction and rationale Myocardial infarction (MI) can be surgically induced in mice. Accurate measurement of infarction size (IS) is regularly…”
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Lack of PI 3-kinase isoform p110alpha in smooth muscle cells impairs aortic wall homoeostasis and thus promotes aortic aneurysm formation by Vantler, M, Berghausen, E, Zierden, M, Mollenhauer, M, Mehrkens, D, Adam, M, Baldus, S, Rosenkranz, S

“…Abstract Background In smooth muscle cells (SMCs), the PI 3-kinase isoform p110α mediates receptor tyrosine kinase dependent proliferation, chemotaxis and cell…”
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PI 3-kinase isoform PI3Kalpha controls smooth muscle cell functionality and protects against aortic aneurysm formation by Vantler, M, Schorscher, M, Berghausen, E, Zierden, M, Wissmueller, M, Mollenhauer, M, Mehrkens, D, Adam, M, Baldus, S, Rosenkranz, S

“…Abstract Background Class I PI 3-kinase isoform PI3Kα is a lipid kinase and signals downstream of receptor tyrosine kinases. Smooth muscle cells (SMCs) lacking…”
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PI 3-kinase/AKT/FOXO1 signaling in smooth muscle cells protects against abdominal aortic aneurysm by Vantler, M, Schorscher, M, Berghausen, E M, Wong, D W L, Zhao, X, Gnatzy-Feik, L, Zierden, M, Mehrkens, D, Odenthal, M, Boor, P, Maegdefessel, L, Baldus, S, Rosenkranz, S

“…Abstract Background Abdominal aortic aneurysms (AAA) are characterized by loss of vascular smooth muscle cells (SMCs). Growth factors induce proliferation and…”
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Lack of PI 3-kinase isoform p110alpha impairs SMC differentiation and proliferation and promotes aortic aneurysm formation by Vantler, M, Schorscher, M, Moore, J B, Berhausen, E M, Zierden, M, Mollenhauer, M, Adam, M, Mehrkens, D, Baldus, S, Rosenkranz, S

“…Abstract Background Proliferation and phenotypic modulation of vascular smooth muscle cells (SMCs) significantly contribute to the functionality of the aortic…”
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Olfactory receptor 2 signaling drives experimental abdominal aortic aneurysm formation by Schelemei, P, Picard, F, Nemade, H, Mehrkens, D, Grimm, S, Tinaz, K, Wagner, E, Orrechioni, M, Wagenhaeuser, M, Schelzig, H, Roy, J, Liljeqvist, M, Mollenhauer, M, Baldus, S, Winkels, H

“…Abstract Background Abdominal aortic aneurysms (AAA) are defined as enlargement above 3cm or 50% of its original diameter. Therapeutic options are limited to…”
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Importance of smooth muscle p110alpha/AKT/FOXO1 signaling for the development of abdominal aortic aneurysm by Vantler, M, Schorscher, M, Berghausen, E M, Moore Iv, J B, Wong, D, Li, Z, Gnatzy-Feik, L, Zierden, M, Mehrkens, D, Adam, M, Sengle, G, Boor, P, Maegdefessel, L, Baldus, S, Rosenkranz, S

“…Abstract Background Abdominal aortic aneurysms (AAA) are characterized by loss of vascular smooth muscle cells (SMCs) and extracellular matrix (ECM)…”
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Deficiency of olfactory receptor 2 worsens cardiac function and increases infarct size after myocardial infarction by Wagner, E., Torun, M., Geißen, S., Mehrkens, D., Nettersheim, F., Grimm, S., Hof, A., Tinaz, K., Pfeiler, S., Gerdes, N., Mollenhauer, M., Baldus, S., Orecchioni, M., Ley, K., Winkels, H.

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Olfactory receptor 2 signaling drives abdominal aortic aneurysm formation by Schelemei, Patrik, Ruben Picard, Felix Simon, Nemade, Harshal, Mehrkens, Dennis, Tinaz, Katharina, Grimm, Simon, Orecchioni, Marco, Wagenhäuser, Markus, Schelzig, Hubert, Roy, Joy, Liljeqvist, Moritz Lindquist, Baldus, Stephan, Mollenhauer, Martin, Winkels, Holger

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P1937Deficiency of PI 3-kinase isoform p110alpha in smooth muscle cells impairs vascular integrity and promotes aortic aneurysm formation by Vantler, M, Berghausen, E M, Zierden, M, Mollenhauer, M, Mehrkens, D, Adam, M, Baldus, S, Rosenkranz, S

“…Abstract Background The pathobiology of aortic aneurysms is characterized by vascular inflammation, extracellular matrix degeneration, and particularly by loss…”
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P2310Cardiac hypertrophy, fibrosis and diastolic dysfunction are attenuated upon administration of nitro oleic acid in a murine model of hypertensive heart disease by Geissen, S., Mehrkens, D., Schaetzle, A.K., Mollenhauer, M., Adam, M., Klinke, A., Baldus, S., Rudolph, V.

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P4551Myeloperoxidase activity aggravates aortic wall remodeling and participates in aneurysm development in Marfan Syndrome by Mehrkens, D, Dohr, J K, Mollenhauer, M, Kochen, M, Silva, A, Sengle, G, Rudolph, V, Klinke, A, Adam, M, Baldus, S

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Systemic Upregulation of IL-10 (Interleukin-10) Using a Nonimmunogenic Vector Reduces Growth and Rate of Dissecting Abdominal Aortic Aneurysm by Adam, Matti, Kooreman, Nigel Geoffrey, Jagger, Ann, Wagenhäuser, Markus U, Mehrkens, Dennis, Wang, Yongming, Kayama, Yosuke, Toyama, Kensuke, Raaz, Uwe, Schellinger, Isabel N, Maegdefessel, Lars, Spin, Joshua M, Hamming, Jaap F, Quax, Paul H.A, Baldus, Stephan, Wu, Joseph C, Tsao, Philip S

“…OBJECTIVE—Recruitment of immunologic competent cells to the vessel wall is a crucial step in formation of abdominal aortic aneurysms (AAA). Innate immunity…”
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Nitro-Oleic Acid (NO 2 -OA) Improves Systolic Function in Dilated Cardiomyopathy by Attenuating Myocardial Fibrosis by Braumann, Simon, Schumacher, Wibke, Im, Nam Gyu, Nettersheim, Felix Sebastian, Mehrkens, Dennis, Bokredenghel, Senai, Hof, Alexander, Nies, Richard Julius, Adler, Christoph, Winkels, Holger, Knöll, Ralph, Freeman, Bruce A, Rudolph, Volker, Klinke, Anna, Adam, Matti, Baldus, Stephan, Mollenhauer, Martin, Geißen, Simon

“…Nitro-oleic acid (NO -OA), a nitric oxide (NO)- and nitrite (NO )-derived electrophilic fatty acid metabolite, displays anti-inflammatory and anti-fibrotic…”
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Pallidal neurostimulation in patients with medication-refractory cervical dystonia: a randomised, sham-controlled trial by Volkmann, Jens, Prof, Mueller, Joerg, MD, Deuschl, Günther, Prof, Kühn, Andrea A, Prof, Krauss, Joachim K, Prof, Poewe, Werner, Prof, Timmermann, Lars, Prof, Falk, Daniela, MD, Kupsch, Andreas, MD, Kivi, Anatol, MD, Schneider, Gerd-Helge, MD, Schnitzler, Alfons, Prof, Südmeyer, Martin, MD, Voges, Jürgen, Prof, Wolters, Alexander, MD, Wittstock, Matthias, MD, Müller, Jan-Uwe, MD, Hering, Sascha, MD, Eisner, Wilhelm, MD, Vesper, Jan, Prof, Prokop, Thomas, MD, Pinsker, Marcus, MD, Schrader, Christoph, MD, Kloss, Manja, MD, Kiening, Karl, MD, Boetzel, Kai, MD, Mehrkens, Jan, MD, Skogseid, Inger Marie, MD, Ramm-Pettersen, Jon, MD, Kemmler, Georg, PhD, Bhatia, Kailash P, Prof, Vitek, Jerrold L, Prof, Benecke, Reiner, Prof

“…Summary Background Cervical dystonia is managed mainly by repeated botulinum toxin injections. We aimed to establish whether pallidal neurostimulation could…”
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Mechanistic Determination of Notochordal Cell-Induced Anti-Apoptotic Signaling in Human Nucleus Pulposus Cells by Mehrkens, Arne, MD, Zia Karim, M., DVM, MSc (Hons), MPhil, Matta, Ajay, PhD, Kim, Sarah, BSc, Hilario, Raychel, BSc, Fehlings, Michael G., MD PhD FRCSC, Mark Erwin, W., DC, PhD

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