Search Results - "Mehnert, Martin"

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases by Buljan, Marija, Ciuffa, Rodolfo, van Drogen, Audrey, Vichalkovski, Anton, Mehnert, Martin, Rosenberger, George, Lee, Sohyon, Varjosalo, Markku, Pernas, Lucia Espona, Spegg, Vincent, Snijder, Berend, Aebersold, Ruedi, Gstaiger, Matthias

“…Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell…”
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Multi-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes by Mehnert, Martin, Ciuffa, Rodolfo, Frommelt, Fabian, Uliana, Federico, van Drogen, Audrey, Ruminski, Kilian, Gstaiger, Matthias, Aebersold, Ruedi

“…Rapidly increasing availability of genomic data and ensuing identification of disease associated mutations allows for an unbiased insight into genetic drivers…”
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Phosphorylation‐linked complex profiling identifies assemblies required for Hippo signal integration by Uliana, Federico, Ciuffa, Rodolfo, Mishra, Ranjan, Fossati, Andrea, Frommelt, Fabian, Keller, Sabrina, Mehnert, Martin, Birkeland, Eivind Salmorin, van Drogen, Frank, Srejic, Nevena, Peter, Matthias, Tapon, Nicolas, Aebersold, Ruedi, Gstaiger, Matthias

“…While several computational methods have been developed to predict the functional relevance of phosphorylation sites, experimental analysis of the…”
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The interplay of Hrd3 and the molecular chaperone system ensures efficient degradation of malfolded secretory proteins by Mehnert, Martin, Sommermeyer, Franziska, Berger, Maren, Kumar Lakshmipathy, Sathish, Gauss, Robert, Aebi, Markus, Jarosch, Ernst, Sommer, Thomas

“…Misfolded proteins of the secretory pathway are extracted from the endoplasmic reticulum (ER), polyubiquitylated by a protein complex termed the Hmg-CoA…”
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Analysis of the interferon-γ-induced secretome of intestinal endothelial cells: putative impact on epithelial barrier dysfunction in IBD by Naschberger, Elisabeth, Flierl, Christian, Huang, Jinghao, Erkert, Lena, Gamez-Belmonte, Reyes, Gonzalez-Acera, Miguel, Bober, Magdalena, Mehnert, Martin, Becker, Christoph, Schellerer, Vera S., Britzen-Laurent, Nathalie, Stürzl, Michael

“…The development of inflammatory bowel diseases (IBD) involves the breakdown of two barriers: the epithelial barrier and the gut-vascular barrier (GVB). The…”
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ERAD ubiquitin ligases by Mehnert, Martin, Sommer, Thomas, Jarosch, Ernst

“…In eukaryotic cells terminally misfolded proteins of the secretory pathway are retarded in the endoplasmic reticulum (ER) and subsequently degraded in a…”
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Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane by Mehnert, Martin, Sommer, Thomas, Jarosch, Ernst

“…Misfolded proteins of the secretory pathway are extracted from the endoplasmic reticulum (ER), polyubiquitylated by a protein complex termed the Hmg-CoA…”
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Combining Rapid Data Independent Acquisition and CRISPR Gene Deletion for Studying Potential Protein Functions: A Case of HMGN1 by Mehnert, Martin, Li, Wenxue, Wu, Chongde, Salovska, Barbora, Liu, Yansheng

“…CRISPR‐Cas gene editing holds substantial promise in many biomedical disciplines and basic research. Due to the important functional implications of…”
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Protein dislocation from the ER by Bagola, Katrin, Mehnert, Martin, Jarosch, Ernst, Sommer, Thomas

“…Protein folding within the endoplasmic reticulum (ER) of eukaryotic cells is erroneous and often results in the formation of terminally malfolded species. A…”
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Multi-omic measurements of heterogeneity in HeLa cells across laboratories by Liu, Yansheng, Mi, Yang, Mueller, Torsten, Kreibich, Saskia, Williams, Evan G., Van Drogen, Audrey, Borel, Christelle, Frank, Max, Germain, Pierre-Luc, Bludau, Isabell, Mehnert, Martin, Seifert, Michael, Emmenlauer, Mario, Sorg, Isabel, Bezrukov, Fedor, Bena, Frederique Sloan, Zhou, Hu, Dehio, Christoph, Testa, Giuseppe, Saez-Rodriguez, Julio, Antonarakis, Stylianos E., Hardt, Wolf-Dietrich, Aebersold, Ruedi

“…Reproducibility in research can be compromised by both biological and technical variation, but most of the focus is on removing the latter. Here we investigate…”
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Assessment of Ultra-Deep Mass Spectrometry Based Proteomics Compared to Flow Cytometry and RNA-Based Methods for the Discovery and Validation of Therapeutic Targets in Immune Cells by Au, Yu-Wah, Rigter, Gemma, Yu, Wingyan, Satijn, David, Mehnert, Martin, Lachaud, Amaury, Vowinckel, Jakob, Neijssen, Joost, Bon, Helene

“…Immuno-oncology (IO) has substantially improved the survival of cancer patients over the past several years encouraging the discovery of novel IO targets which…”
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ERAD ubiquitin ligases: multifunctional tools for protein quality control and waste disposal in the endoplasmic reticulum by Mehnert, Martin, Sommer, Thomas, Jarosch, Ernst

“…In eukaryotic cells terminally misfolded proteins of the secretory pathway are retarded in the endoplasmic reticulum (ER) and subsequently degraded in a…”
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Novel biochemical, structural, and systems insights into inflammatory signaling revealed by contextual interaction proteomics by Ciuffa, Rodolfo, Uliana, Federico, Mannion, Jonathan, Mehnert, Martin, Tenev, Tencho, Marulli, Cathy, Satanowski, Ari, Keller, Lena Maria Leone, Rodilla Ramírez, Pilar Natalia, Ori, Alessandro, Gstaiger, Matthias, Meier, Pascal, Aebersold, Ruedi

“…Protein-protein interactions (PPIs) represent the main mode of the proteome organization in the cell. In the last decade, several large-scale representations…”
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Abstract PR013: Highly accurate detection of early-stage colorectal cancer using tumor and immune extracellular vesicles biomarkers by Mudgal, Poorva, Bandoski, Cheryl, Opheim, Zachary, Mehnert, Martin, Anschau, Valesca, Isaac, Issa, Ezrin, Alan, Hembrough, Todd

“…Abstract Introduction: Colorectal cancer (CRC) is one of the most common cancers worldwide, and early detection is critical for successful treatment and…”
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Abstract A063: Highly accurate detection of early-stage colorectal cancer using tumor and immune extracellular vesicles biomarkers by Mudgal, Poorva, Bandoski, Cheryl, Opheim, Zachary, Mehnert, Martin, Anschau, Valesca, Isaac, Issa, Ezrin, Alan, Hembrough, Todd

“…Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR013) of…”
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Abstract 3746: Identification of cancer specific extracellular vesical biomarkers to aid in diagnosis of cancer by Hembrough, Todd A., Opheim, Zachary, Bandoski, Cheryl, Isaac, Issa, Mehnert, Martin, Ezrin, Alan

“…Abstract The limitations of serial tumor biopsies are well known, thus liquid biopsies which allow for repeated plasma-based biomarker analysis are urgently…”
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Abstract 3974: Discovery and validation of therapeutic targets in immune cells by mass spectrometry-based proteomics by Au, Yu-Wah, Satijn, David, Mehnert, Martin, Lachaud, Amaury, Feng, Yuehan, Vowinckel, Jakob, Bon, Hélène

“…Abstract Immuno-oncology (IO) has substantially improved the survival of cancer patients over the past several years encouraging the discovery of novel IO…”
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Abstract 5149: Extracellular matrix remodeling in metastatic mismatch repair deficient endometrial cancer:Implications for immune checkpoint inhibitor response prediction by Grau, Juan Francisco, Aimé, Carole, Mehnert, Martin, Yaniz-Galende, Elisa, Genestie, Catherine, Formal, Audrey Le, Edmond, Elodie, Lachaud, Antoine Amaury, Pautier, Patricia, Michels, Judith, Gouy, Sébastien, Maulard, Amandine, Colomba-Blameble, Emeline, Blanc-Durand, Felix, Schanne-Klein, Marie-Claire, Leary, Alexandra

“…Abstract Mismatch repair deficient (MMRd) status is a predictive biomarker for Immune checkpoint inhibitors (ICI) in endometrial cancer (EC), however, half of…”
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Abstract 185: Global mapping of pathway modules and phosphorylation networks in PDX and corresponding organoid (PDXO) models treated with targeted therapies by Mehnert, Martin, Xu, Xiaoxi, Treiber, Tobias, Shang, Limei, Chen, Leilei, Wang, Jessie, Tognetti, Marco, Below, Christopher, Bruderer, Roland, Vowinckel, Jakob, Mao, Binchen, Qian, Wubin, Guo, Sheng, Bourré, Ludovic, Feng, Yuehan

“…Abstract Introduction: Multi-omics-based strategies in precision medicine, including genomic, transcriptomic and proteomic data, have contributed to the…”
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