Prognostic implications of bleeding measured by Bleeding Academic Research Consortium (BARC) categorisation in patients undergoing primary percutaneous coronary intervention

To investigate the relationship between inhospital bleeding as defined by Bleeding Academic Research Consortium (BARC) consensus classification and short-term and long-term mortality in unselected patients admitted for primary percutaneous coronary intervention (PCI). We analysed data of all consecu...

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Bibliographic Details
Published in:	Heart (British Cardiac Society) Vol. 100; no. 2; p. 146
Main Authors:	Matic, Dragan M, Milasinovic, Dejan G, Asanin, Milika R, Mrdovic, Igor B, Marinkovic, Jelena M, Kocev, Nikola I, Marjanovic, Marija M, Antonijevic, Nebojsa M, Vukcevic, Vladan D, Savic, Lidija Z, Zivkovic, Milorad N, Mehmedbegovic, Zlatko H, Dedovic, Vladimir M, Stankovic, Goran R
Format:	Journal Article
Language:	English
Published:	England 01-01-2014
Subjects:	Aged Angioplasty, Balloon, Coronary Anticoagulants - adverse effects Cohort Studies Female Hemorrhage - classification Hemorrhage - etiology Hemorrhage - mortality Humans Longitudinal Studies Male Middle Aged Myocardial Infarction - mortality Myocardial Infarction - therapy Percutaneous Coronary Intervention - adverse effects Platelet Aggregation Inhibitors - adverse effects Prognosis Proportional Hazards Models Prospective Studies Risk Assessment Risk Factors Stents Treatment Outcome
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Summary:	To investigate the relationship between inhospital bleeding as defined by Bleeding Academic Research Consortium (BARC) consensus classification and short-term and long-term mortality in unselected patients admitted for primary percutaneous coronary intervention (PCI). We analysed data of all consecutive patients with ST segment elevation myocardial infarction (STEMI) admitted for primary PCI, enrolled in a prospective registry of a high volume centre. The BARC-defined bleeding events were reconstructed from the detailed, prospectively collected clinical data. The primary outcome was mortality at 1 year. Of the 1808 patients with STEMI admitted for primary PCI, 115 (6.4%) experienced a BARC type ≥2 bleeding. As the BARC bleeding severity worsened, there was a gradient of increasing rates of 1-year death. The 1-year mortality rate increased from 11.5% with BARC 0+1 type to 43.5% with BARC type 3b bleeding. After multivariable adjustment for demographic and clinical characteristics of patients, the independent predictors of 1-year death were BARC type 3a (HR 1.99; 95% CI 1.16 to 3.40, p=0.012) and BARC type 3b bleeding (HR 3.22; 95% CI 1.67 to 6.20, p<0.0001). The present study demonstrated that bleeding events defined according to the BARC classification hierarchically correlate with 1-year mortality after admission for primary PCI. The strongest predictor of 1-year mortality is the BARC type 3b bleeding.
ISSN:	1468-201X
DOI:	10.1136/heartjnl-2013-304564