Search Results - "Mehigan, Brian"

Current targeted therapies in the treatment of advanced colorectal cancer: a review by Moriarity, Andrew, O’Sullivan, Jacintha, Kennedy, John, Mehigan, Brian, McCormick, Paul

“…Treatment strategies for metastatic colorectal cancer (mCRC) patients have undergone dramatic changes in the past decade and despite improved patient outcomes,…”
Get full text

Survival outcomes after synchronous para‐aortic lymph node metastasis in colorectal cancer: A systematic review by Aylward, Conor, Noori, Jawed, Tyrrell, Jack, O'sullivan, Niall, Kavanagh, Dara O., Larkin, John O., Mehigan, Brian J., McCormick, Paul H., Kelly, Michael E.

“…Background Synchronous para‐aortic lymph node metastasis (PALNM) in colorectal cancer (CRC) is a relatively rare clinical entity. There is a lack of consensus…”
Get full text

Quality of life meta‐analysis following coloanal anastomosis versus abdominoperineal resection for low rectal cancer by Maguire, Barry, Clancy, Cillian, Connelly, Tara M., Mehigan, Brian J., McCormick, Paul, Altomare, Donato F., Gosselink, Martijn Pieter, Larkin, John O.

“…Aim In low rectal cancers without sphincter involvement a permanent stoma can be avoided without compromising oncological safety. Functional outcomes following…”
Get full text

Assessing Circulating Tumour DNA (ctDNA) as a Biomarker for Anal Cancer Management: A Systematic Review by Temperley, Hugo C, Fannon, Timothy, O'Sullivan, Niall J, O'Neill, Maeve, Mac Curtain, Benjamin M, Gilham, Charles, O'Sullivan, Jacintha, O'Kane, Grainne, Mehigan, Brian J, O'Toole, Sharon, Larkin, John O, Gallagher, David, McCormick, Paul, Kelly, Michael E

“…This systematic review investigates the potential of circulating tumour DNA (ctDNA) as a predictive biomarker in the management and prognosis of squamous cell…”
Get full text

Obesity and anastomotic leak rates in colorectal cancer: a meta-analysis by Nugent, Timothy S., Kelly, Michael E., Donlon, Noel E., Fahy, Matthew R., Larkin, John O., McCormick, Paul H., Mehigan, Brian J.

“…Purpose Anastomotic leak (AL) following colorectal cancer resection is associated with considerable morbidity and mortality with an impact on recurrence rates…”
Get full text

Radiomics; Contemporary Applications in the Management of Anal Cancer; A Systematic Review by Temperley, Hugo C, O'Sullivan, Niall J, Waters, Caitlin, Corr, Alison, Mehigan, Brian J, O'Kane, Grainne, McCormick, Paul, Gillham, Charles, Rausa, Emanuele, Larkin, John O, Meaney, James F, Brennan, Ian, Kelly, Michael E

“…The management of anal cancer relies on clinical and histopathological features for treatment decisions. In recent years, the field of radiomics, which…”
Get more information

Complement is increased in treatment resistant rectal cancer and modulates radioresistance by O'Brien, Rebecca M., Meltzer, Sebastian, Buckley, Croí E., Heeran, Aisling B., Nugent, Timothy S., Donlon, Noel E., Reynolds, John V., Ree, Anne Hansen, Redalen, Kathrine Røe, Hafeez, Adnan, O’Ríordáin, Diarmuid S., Hannon, Robert A., Neary, Paul, Kalbassi, Reza, Mehigan, Brian J., McCormick, Paul H., Dunne, Cara, Kelly, Michael E., Larkin, John O., O'Sullivan, Jacintha, Lysaght, Joanne, Lynam-Lennon, Niamh

“…Resistance to neoadjuvant chemoradiation therapy (neo-CRT) is a significant clinical problem in the treatment of locally advanced rectal cancer. Identification…”
Get full text

Robotic transanal minimally invasive surgery (R-TAMIS): current evidence in the treatment of early rectal neoplasia by O’Sullivan, Niall J., Temperley, Hugo C., Larkin, John, McCormick, Jacob J., Rausa, Emanuele, McCormick, Paul, Heriot, Alexander, Mehigan, Brian J., Warrier, Satish, Kelly, Michael E.

“…Introduction Robotic transanal minimally invasive surgery (R-TAMIS) was introduced in 2012 for the excision of benign rectal polyps and low grade rectal…”
Get full text

Extramural venous invasion (EMVI) in colorectal cancer is associated with increased cancer recurrence and cancer-related death by Mc Entee, Philip D, Shokuhi, Poorya, Rogers, Ailin C, Mehigan, Brian J, McCormick, Paul H, Gillham, Charles M, Kennedy, M John, Gallagher, David J, Ryan, Ciara E, Muldoon, Cian B, Larkin, John O

“…Colorectal cancer (CRC) outcomes vary depending on tumour biology, with several features used to predict disease behaviour. Extramural venous invasion (EMVI)…”
Get full text

Prophylactic negative pressure wound therapy for closed laparotomy wounds: a systematic review and meta-analysis of randomised controlled trials by Boland, Patrick Anthony, Kelly, Michael E., Donlon, Noel E., Bolger, Jarlath C., Mehigan, Brian J., McCormick, Paul H., Larkin, John O.

“…Surgical site infections are a common source of post-operative morbidity and contribute significantly to healthcare costs. Patients undergoing emergency…”
Get full text

Factors Influencing Outcomes and Survival in Anal Cancer by Temperley, Hugo C, Mac Curtain, Benjamin M, O'Sullivan, Niall J, Mulhall, Cormac, Temperley, Tatiana S, Mehigan, Brian J, Larkin, John O, McCormick, Paul H, Kerr, Colm, Gallagher, David, Bergin, Colm, Gillham, Charles, Kelly, Michael E

“…We aim to ascertain prognostic factors in the current management of anal cancer within this study. We reviewed the management and outcomes of anal cancer cases…”
Get full text

Gastrointestinal Stromal Tumours (GIST) of the Rectum: A Systematic Review and Meta-Analysis by Khan, Shaheer I, O'Sullivan, Niall J, Temperley, Hugo C, Rausa, Emanuele, Mehigan, Brian J, McCormick, Paul, Larkin, John O, Kavanagh, Dara O, Kelly, Michael E

“…Background: Rectal gastrointestinal stromal tumours (GISTs) have many treatment options, but uncertainty remains regarding the best treatment regimen for this…”
Get full text

Prostate radiotherapy and the risk of secondary rectal cancer—a meta-analysis by Nugent, Timothy S., Low, Ernest Z., Fahy, Matthew R., Donlon, Noel E., McCormick, Paul H., Mehigan, Brian J., Cunningham, Moya, Gillham, Charles, Kavanagh, Dara O., Kelly, Michael E., Larkin, John O.

“…Purpose Radiotherapy is being used increasingly in the treatment of prostate cancer. However, ionising radiation may confer a small risk of a radiation-induced…”
Get full text

Optimal surgical management strategy for treatment of primary anorectal malignant melanoma—a systematic review and meta-analysis by Temperley, Hugo C., O’Sullivan, Niall J., Keyes, Alan, Kavanagh, Dara O., Larkin, John O., Mehigan, Brian J., McCormick, Paul H., Kelly, Michael E.

“…Background Primary mucosal anorectal malignant melanoma (AMM) is an invasive malignancy with poor survival. Management options have been variable, due to…”
Get full text

Sigmoid volvulus: definitive surgery is safe and should be considered in all instances by Hardy, Niall P., McEntee, Philip D., McCormick, Paul H., Mehigan, Brian J., Larkin, John O.

“…Background Acute sigmoid volvulus (ASV) represents a small but significant portion of cases of large bowel obstruction, especially in the elderly and…”
Get full text

Application of PREVENA (Surgical Incision Protection System) in reducing surgical site infections following reversal of ileostomy or colostomy: the PRIC study protocol by Low, Ernest Z., Nugent, Timothy S., O’Sullivan, Niall J., Kavanagh, Dara, Larkin, John O., McCormick, Paul H., Mehigan, Brian J., Kelly, Michael E.

“…Aim There is a current lack of evidence in the literature to support the routine use of negative pressure wound therapy (NPWT) to reduce the risk of surgical…”
Get full text

Combining 1,4-dihydroxy quininib with Bevacizumab/FOLFOX alters angiogenic and inflammatory secretions in ex vivo colorectal tumors by Kennedy, Susan A, Morrissey, Maria E, Dunne, Margaret R, O'Connell, Fiona, Butler, Clare T, Cathcart, Mary-Clare, Buckley, Amy M, Mehigan, Brian J, Larkin, John O, McCormick, Paul, Kennedy, Breandán N, O'Sullivan, Jacintha

“…Colorectal cancer (CRC) is the second most common cause of cancer-related mortality worldwide with one in every five patients diagnosed with metastatic CRC…”
Get full text

Metformin is a metabolic modulator and radiosensitiser in rectal cancer by Buckley, Croí E., O’Brien, Rebecca M., Nugent, Timothy S., Donlon, Noel E., O’Connell, Fiona, Reynolds, John V., Hafeez, Adnan, O’Ríordáin, Diarmuid S., Hannon, Robert A., Neary, Paul, Kalbassi, Reza, Mehigan, Brian J., McCormick, Paul H., Dunne, Cara, Kelly, Michael E., Larkin, John O., O’Sullivan, Jacintha, Lynam-Lennon, Niamh

“…Resistance to neoadjuvant chemoradiation therapy, is a major challenge in the management of rectal cancer. Increasing evidence supports a role for altered…”
Get full text

Prognostic value of pre-operative mean corpuscular volume (MCV) in colorectal cancer by Shokuhi, Poorya, O’Sullivan, Niall J., Temperley, Hugo C., Russell, Thomas, McEntee, Philip D., Mehigan, Brian J., McCormick, Paul H., Gallagher, David, Gillham, Charles, Kennedy, John, Kelly, Michael E., Larkin, John O.

“…Background Mean corpuscular volume (MCV) has been shown to have some correlation to oncological outcomes in oesophageal cancer, with high pre-operative MCV…”
Get full text

The tumour microenvironment of the upper and lower gastrointestinal tract differentially influences dendritic cell maturation by Morrissey, Maria E, Byrne, Róisín, Nulty, Celina, McCabe, Niamh H, Lynam-Lennon, Niamh, Butler, Clare T, Kennedy, Susan, O'Toole, Dermot, Larkin, John, McCormick, Paul, Mehigan, Brian, Cathcart, Mary-Clare, Lysaght, Joanne, Reynolds, John V, Ryan, Elizabeth J, Dunne, Margaret R, O'Sullivan, Jacintha

“…Only 10-30% of oesophageal and rectal adenocarcinoma patients treated with neoadjuvant chemoradiotherapy have a complete pathological response. Inflammatory…”
Get full text