Search Results - "Mehdi, Karkouri"
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The immune checkpoint VISTA exhibits high expression levels in human gliomas and associates with a poor prognosis
Published in Scientific reports (02-11-2021)“…In human gliomas, anti-tumor T cell responses are inhibited through induction of local and systemic immunosuppression. Immune checkpoint blockade is proving to…”
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The Promising IgSF11 Immune Checkpoint Is Highly Expressed in Advanced Human Gliomas and Associates to Poor Prognosis
Published in Frontiers in oncology (02-02-2021)“…Glioma is the most prevalent primary brain tumor. Immune checkpoint blockade has made a great stride in mending patient's clinical outcome for multiple types…”
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The immune checkpoint adenosine 2A receptor is associated with aggressive clinical outcomes and reflects an immunosuppressive tumor microenvironment in human breast cancer
Published in Frontiers in immunology (11-09-2023)“…BackgroundThe crosstalk between the immune system and cancer cells has aroused considerable interest over the past decades. To escape immune surveillance…”
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The Clinicopathological Features and Prognostic Significance of HER2-Low in Early Breast Tumors Patients Prognostic Comparison of HER-Low and HER2-Negative Breast Cancer Stratified by Hormone Receptor Status
Published in The breast journal (2023)“…Introduction. There has been increased interest in HER2-low breast tumors recently, as these tumors may have distinct clinical and molecular characteristics…”
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High expression of BTN3A1 is associated with clinical and immunological characteristics and predicts a poor prognosis in advanced human gliomas
Published in Frontiers in immunology (28-05-2024)“…Gliomas represent the most prevalent and aggressive tumors within the central nervous system. Despite the current standard treatments, the median survival time…”
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Determinants and effects or consequences of internal HIV-related stigma among people living with HIV in Morocco
Published in BMC public health (19-01-2021)“…HIV-related stigma and discrimination constitute a barrier to different intervention programs. Unlike external stigma, internal stigma is not well explored in…”
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The immune checkpoint VISTA is associated with prognosis in patients with malignant uveal melanoma
Published in Frontiers in immunology (18-08-2023)“…Uveal melanoma (UM) is a rare yet deadly tumor. It is known for its high metastatic potential, which makes it one of the most aggressive and lethal cancers…”
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TMIGD2 as a potential therapeutic target in glioma patients
Published in Frontiers in immunology (16-05-2023)“…Among all types of central nervous system cancers, glioma remains the most frequent primary brain tumor in adults. Despite significant advances in…”
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Diagnostic Value of Potential MicroRNAs in CRC: A Meta-Analysis
Published in MicroRNA (Shariqah, United Arab Emirates) (01-01-2022)“…MicroRNAs (miRNAs) are small noncoding RNA molecules involved in the post-transcriptional regulation of genes. Deregulated expression of miRNAs is involved in…”
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High VISTA expression is linked to a potent epithelial-mesenchymal transition and is positively correlated with PD1 in breast cancer
Published in Frontiers in oncology (20-04-2023)“…Breast cancer is the most common type of tumor in women worldwide. Immune checkpoint inhibitors, particularly anti-PDL1, have shown promise as a therapeutic…”
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Induced pathophysiological alterations by the venoms of the most dangerous Moroccan scorpions Androctonus mauretanicus and Buthus occitanus: A comparative pathophysiological and toxic-symptoms study
Published in Human & experimental toxicology (01-01-2022)“…Scorpion envenomation is a serious public health issue. Androctonus mauretanicus (Am) and Buthus occitanus (Bo) are the most dangerous scorpions in Morocco…”
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Investigating tumor immunogenicity in breast cancer: deciphering the tumor immune response to enhance therapeutic approaches
Published in Frontiers in immunology (23-10-2024)“…The interplay between immune cells and malignant cells represents an essential chapter in the eradication of breast cancer. This widely distributed and diverse…”
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Acceptability and usability of oral fluid-based HIV self-testing among female sex workers and men who have sex with men in Morocco
Published in BMC public health (05-12-2022)“…In 2020, almost 20% of people living with HIV (PLHIV) in Morocco are still unaware of their HIV status. Under these circumstances, HIV self-test (HIVST) can be…”
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Correction: Acceptability and usability of oral fluid-based HIV self-testing among female sex workers and men who have sex with men in Morocco
Published in BMC public health (28-12-2022)Get full text
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Fear of stigma from health professionals and family/neighbours and healthcare avoidance among PLHIV in Morocco: results from the Stigma Index survey Morocco
Published in BMC public health (08-09-2022)“…Background Enacted or anticipated stigma among people living with HIV (PLHIV) can negatively impact healthcare engagement. We identified factors associated…”
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Assessing the efficacy of monovalent and commercialized antivenoms for neutralizing Moroccan cobra 'Naja haje' venom: A comparative study
Published in Tropical medicine and infectious disease (02-06-2023)“…In Morocco, eight species of venomous snakes belonging to the 'Viperidae' and 'Elapidae' families are responsible for severe envenomation cases. The species…”
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Management of Ptosis in Kearns-Sayre Syndrome: A Case Report and Literature Review
Published in Archives of plastic surgery (01-03-2024)“…Kearns-Sayre syndrome (KSS) is a rare mitochondrial disease that affects young adults, due to a deletion of mitochondrial DNA and characterized by the triad:…”
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Glioblastoma Vaccines as Promising Immune-Therapeutics: Challenges and Current Status
Published in Vaccines (Basel) (12-06-2024)“…Glioblastoma (GBM) is the most common and aggressive malignant brain tumor. Standard treatments including surgical resection, radiotherapy, and chemotherapy,…”
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Glioblastoma Following Treated Medulloblastoma After 29 Years in the Posterior Fossa: Case Report and Review of Literature
Published in Frontiers in oncology (13-04-2022)“…Glioblastoma multiforme (GBM) is a high-grade glioma that may be a rare complication of radiotherapy. We report a case of a patient who was treated for…”
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Risk factors for inflammatory and non-inflammatory breast cancer in North Africa
Published in Breast cancer research and treatment (01-11-2020)“…Purpose Studies of the etiology of inflammatory breast cancer (IBC), a rare but aggressive breast cancer, have been hampered by limited risk factor…”
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