Search Results - "Meharena, Hiruy"

Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers by Hu, Jiancheng, Stites, Edward C., Yu, Haiyang, Germino, Elizabeth A., Meharena, Hiruy S., Stork, Philip J.S., Kornev, Alexandr P., Taylor, Susan S., Shaw, Andrey S.

“…Although RAF kinases are critical for controlling cell growth, their mechanism of activation is incompletely understood. Recently, dimerization was shown to be…”
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Deciphering the structural basis of eukaryotic protein kinase regulation by Meharena, Hiruy S, Chang, Philip, Keshwani, Malik M, Oruganty, Krishnadev, Nene, Aishwarya K, Kannan, Natarajan, Taylor, Susan S, Kornev, Alexandr P

“…Eukaryotic protein kinases (EPKs) regulate numerous signaling processes by phosphorylating targeted substrates through the highly conserved catalytic domain…”
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Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity by Victor, Matheus B., Leary, Noelle, Luna, Xochitl, Meharena, Hiruy S., Scannail, Aine Ni, Bozzelli, P. Lorenzo, Samaan, George, Murdock, Mitchell H., von Maydell, Djuna, Effenberger, Audrey H., Cerit, Oyku, Wen, Hsin-Lan, Liu, Liwang, Welch, Gwyneth, Bonner, Maeve, Tsai, Li-Huei

“…Apolipoprotein E4 (APOE4) is the greatest known genetic risk factor for developing sporadic Alzheimer’s disease. How the interaction of APOE4 microglia with…”
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Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble by Marco, Asaf, Meharena, Hiruy S., Dileep, Vishnu, Raju, Ravikiran M., Davila-Velderrain, Jose, Zhang, Amy Letao, Adaikkan, Chinnakkaruppan, Young, Jennie Z., Gao, Fan, Kellis, Manolis, Tsai, Li-Huei

“…The epigenome and three-dimensional (3D) genomic architecture are emerging as key factors in the dynamic regulation of different transcriptional programs…”
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Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration by Dileep, Vishnu, Boix, Carles A., Mathys, Hansruedi, Marco, Asaf, Welch, Gwyneth M., Meharena, Hiruy S., Loon, Anjanet, Jeloka, Ritika, Peng, Zhuyu, Bennett, David A., Kellis, Manolis, Tsai, Li-Huei

“…Persistent DNA double-strand breaks (DSBs) in neurons are an early pathological hallmark of neurodegenerative diseases including Alzheimer’s disease (AD), with…”
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Evolution of a dynamic molecular switch by Taylor, Susan S., Meharena, Hiruy S., Kornev, Alexandr P.

“…Eukaryotic protein kinases (EPKs) regulate almost every biological process and have evolved to be dynamic molecular switches; this is in stark contrast to…”
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From neurodevelopment to neurodegeneration: utilizing human stem cell models to gain insight into Down syndrome by Watson, L Ashley, Meharena, Hiruy S

“…Down syndrome (DS), caused by triplication of chromosome 21, is the most frequent aneuploidy observed in the human population and represents the most common…”
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Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors by Meharena, Hiruy S., Marco, Asaf, Dileep, Vishnu, Lockshin, Elana R., Akatsu, Grace Y., Mullahoo, James, Watson, L. Ashley, Ko, Tak, Guerin, Lindsey N., Abdurrob, Fatema, Rengarajan, Shruthi, Papanastasiou, Malvina, Jaffe, Jacob D., Tsai, Li-Huei

“…Down syndrome (DS) is a genetic disorder driven by the triplication of chromosome 21 (T21) and characterized by a wide range of neurodevelopmental and physical…”
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Kinase Regulation by Hydrophobic Spine Assembly in Cancer by Hu, Jiancheng, Ahuja, Lalima G., Meharena, Hiruy S., Kannan, Natarajan, Kornev, Alexandr P., Taylor, Susan S., Shaw, Andrey S.

“…A new model of kinase regulation based on the assembly of hydrophobic spines has been proposed. Changes in their positions can explain the mechanism of kinase…”
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Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases by Meharena, Hiruy S, Fan, Xiaorui, Ahuja, Lalima G, Keshwani, Malik M, McClendon, Christopher L, Chen, Angela M, Adams, Joseph A, Taylor, Susan S

“…Eukaryotic protein kinases regulate most cellular functions by phosphorylating targeted protein substrates through a highly conserved catalytic core. In the…”
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Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence by Pence, Morgan A, Haste, Nina M, Meharena, Hiruy S, Olson, Joshua, Gallo, Richard L, Nizet, Victor, Kristian, Sascha A

“…BlaI is a repressor of BlaZ, the beta-lactamase responsible for penicillin resistance in Staphylococcus aureus. Through screening a transposon library in S…”
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Pseudokinases from a structural perspective by Taylor, Susan S, Shaw, Andrey, Hu, Jiancheng, Meharena, Hiruy S, Kornev, Alexandr

“…The catalytic (C) subunit of PKA was the first protein kinase structure to be solved, and it continues to serve as the prototype for the protein kinase…”
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A solo luxI-type gene directs acylhomoserine lactone synthesis and contributes to motility control in the marine sponge symbiont Ruegeria sp. KLH11 by Zan, Jindong, Choi, Okhee, Meharena, Hiruy, Uhlson, Charis L, Churchill, Mair E A, Hill, Russell T, Fuqua, Clay

“…Marine sponges harbour abundant and diverse bacterial communities, providing an ideal environment for bacterial cell-density-dependent cell-cell signalling,…”
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Critical Review Evolution of a Dynamic Molecular Switch by Taylor, Susan S., Meharena, Hiruy S., Kornev, Alexandr P.

“…Eukaryotic protein kinases (EPKs) regulate almost every biological process and have evolved to be dynamic molecular switches; this is in stark contrast to…”
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Deciphering the Structural Basis of Eukaryotic Protein Kinase Regulation: e1001680 by Meharena, Hiruy S, Chang, Philip, Keshwani, Malik M, Oruganty, Krishnadev, Nene, Aishwarya K, Kannan, Natarajan, Taylor, Susan S, Kornev, Alexandr P

“…Eukaryotic protein kinases (EPKs) regulate numerous signaling processes by phosphorylating targeted substrates through the highly conserved catalytic domain…”
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Blueprint of the Intramolecular Regulatory Mechanism of Eukaryotic Protein Kinases by Meharena, Hiruy Sibhatu

“…Eukaryotic protein kinases (EPKs) regulate numerous signaling processes by phosphorylating targeted substrates through a highly conserved catalytic domain…”
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Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence: e0136605 by Pence, Morgan A, Haste, Nina M, Meharena, Hiruy S, Olson, Joshua, Gallo, Richard L, Nizet, Victor, Kristian, Sascha A

“…BlaI is a repressor of BlaZ, the beta-lactamase responsible for penicillin resistance in Staphylococcus aureus. Through screening a transposon library in S…”
Get full text