Search Results - "Mehany, Ahmed B M"

Discovery of New VEGFR-2 Inhibitors: Design, Synthesis, Anti-Proliferative Evaluation, Docking, and MD Simulation Studies by Elkaeed, Eslam B, Yousef, Reda G, Khalifa, Mohamed M, Ibrahim, Albaraa, Mehany, Ahmed B M, Gobaara, Ibraheem M M, Alsfouk, Bshra A, Eldehna, Wagdy M, Metwaly, Ahmed M, Eissa, Ibrahim H, El-Zahabi, Mohamed Ayman

“…Four new nicotinamide-based derivatives were designed as antiangiogenic VEGFR-2 inhibitors. The congeners were synthesized possessing the pharmacophoric…”
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Discovery of Some Heterocyclic Molecules as Bone Morphogenetic Protein 2 (BMP-2)-Inducible Kinase Inhibitors: Virtual Screening, ADME Properties, and Molecular Docking Simulations by Belal, Amany, Elkady, Hazem, Al-Karmalawy, Ahmed A, Amin, Ali H, Ghoneim, Mohammed M, El-Sherbiny, Mohamed, Al-Serwi, Rasha Hamed, Abdou, Mohamed Attia, Ibrahim, Mona H, Mehany, Ahmed B. M

“…Bone morphogenetic proteins (BMPs) are growth factors that have a vital role in the production of bone, cartilage, ligaments, and tendons. Tumors’ upregulation…”
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Anticancer, antimicrobial, insecticidal and molecular docking of sarcotrocheliol and cholesterol from the marine soft coral Sarcophyton Trocheliophorum by Bashar, Mansour A.E., Hamed, Abdelaaty, El-Tabakh, Mohamed A. M., Hashem, Amr H., Zaki, Ahmed A., Al-Askar, Abdulaziz A., Abou-Amra, Eman S., El-Beeh, Mohamed E., Mehany, Ahmed B. M., Shaaban, Mohamed, Abdelaziz, Amer M., Shaaban, Khaled A., Hasaballah, Ahmed I.

“…The anticancer, antimicrobial, and insecticidal activities of sarcotrocheliol ( 1 ) and cholesterol ( 2 ) obtained from the soft coral Sarcophyton…”
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Antitrypanosomal, Antitopoisomerase-I, and Cytotoxic Biological Evaluation of Some African Plants Belonging to Crassulaceae; Chemical Profiling of Extract Using UHPLC/QTOF-MS/MS by Hegazy, Mostafa M, Afifi, Wael M, Metwaly, Ahmed M, Radwan, Mohamed M, Abd-Elraouf, Muhamad, Mehany, Ahmed B M, Ahmed, Eman, Enany, Shymaa, Ezzeldin, Shahd, Ibrahim, Adel E, El Deeb, Sami, Mostafa, Ahmad E

“…In our continuous study for some African plants as a source for antitrypanosomally and cytotoxic active drugs, nine different plants belonging to the…”
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Synthesis, EGFR Inhibition and Anti-cancer Activity of New 3,6-dimethyl-1-phenyl-4-(substituted-methoxy)pyrazolo[3,4-d] pyrimidine Derivatives by Bakr, Rania B, Mehany, Ahmed B M, Abdellatif, Khaled R A

“…as EGFR inhibitors, mammalian target of rapamycin (mTOR) inhibitors, Src or dual Src/Abl inhibitors, glycogen synthase kinase-3b (GSK-3b) inhibitors or cyclin…”
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Discovery of new quinolines as potent colchicine binding site inhibitors: design, synthesis, docking studies, and anti-proliferative evaluation by Hagras, Mohamed, El Deeb, Moshira A., Elzahabi, Heba S. A., Elkaeed, Eslam B., Mehany, Ahmed B. M., Eissa, Ibrahim H.

“…Discovering of new anticancer agents with potential activity against tubulin polymerisation is still a promising approach. Colchicine binding site inhibitors…”
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Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors by Belal, Amany, Abdel Gawad, Nagwa M., Mehany, Ahmed B. M., Abourehab, Mohammed A. S., Elkady, Hazem, Al-Karmalawy, Ahmed A., Ismael, Ahmed S.

“…A new series of 1H-pyrrole (6a-c, 8a-c), pyrrolo[3,2-d]pyrimidines (9a-c) and pyrrolo[3,2-e][1, 4]diazepines (11a-c) were designed and synthesised. These…”
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Cetuximab Conjugated with Octreotide and Entrapped Calcium Alginate-beads for Targeting Somatostatin Receptors by Abdellatif, Ahmed A. H., Ibrahim, Mohamed A., Amin, Mohammed A., Maswadeh, Hamzah, Alwehaibi, Muhammed N., Al-Harbi, Sultan N., Alharbi, Zayed A., Mohammed, Hamdoon A., Mehany, Ahmed B. M., Saleem, Imran

“…There is a need to formulate oral cetuximab (CTX) for targeting colorectal cancer, which is reported to express somatostatin receptors (SSTRs). Therefore,…”
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Phytochemical Profiling, In Vitro and In Silico Anti-Microbial and Anti-Cancer Activity Evaluations and Staph GyraseB and h -TOP-IIβ Receptor-Docking Studies of Major Constituents of Zygophyllum coccineum L. Aqueous-Ethanolic Extract and Its Subsequent Fractions: An Approach to Validate Traditional Phytomedicinal Knowledge by Mohammed, Hamdoon A, Khan, Riaz A, Abdel-Hafez, Atef A, Abdel-Aziz, Marwa, Ahmed, Eman, Enany, Shymaa, Mahgoub, Sebaey, Al-Rugaie, Osamah, Alsharidah, Mansour, Aly, Mohamed S A, Mehany, Ahmed B M, Hegazy, Mostafa M

“…, an edible halophytic plant, is part of the traditional medicine chest in the Mediterranean region for symptomatic relief of diabetes, hypertension, wound…”
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Modified Benzoxazole-Based VEGFR-2 Inhibitors and Apoptosis Inducers: Design, Synthesis, and Anti-Proliferative Evaluation by Elwan, Alaa, Abdallah, Abdallah E, Mahdy, Hazem A, Dahab, Mohammed A, Taghour, Mohammed S, Elkaeed, Eslam B, Mehany, Ahmed B M, Nabeeh, Ahmed, Adel, Mohammed, Alsfouk, Aisha A, Elkady, Hazem, Eissa, Ibrahim H

“…This work is one of our efforts to discover potent anticancer agents. We modified the most promising derivative of our previous work concerned with the…”
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Screening a Panel of Topical Ophthalmic Medications against MMP-2 and MMP-9 to Investigate Their Potential in Keratoconus Management by Belal, Amany, Elanany, Mohamed A, Santali, Eman Y, Al-Karmalawy, Ahmed A, Aboelez, Moustafa O, Amin, Ali H, Abdellattif, Magda H, Mehany, Ahmed B M, Elkady, Hazem

“…Keratoconus (KC) is a serious disease that can affect people of any race or nationality, although the exact etiology and pathogenic mechanism are still…”
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Discovery of new nicotinamides as apoptotic VEGFR-2 inhibitors: virtual screening, synthesis, anti-proliferative, immunomodulatory, ADMET, toxicity, and molecular dynamic simulation studies by Yousef, Reda G., Ibrahim, Albaraa, Khalifa, Mohamed M., Eldehna, Wagdy M., Gobaara, Ibraheem M. M., Mehany, Ahmed B. M., Elkaeed, Eslam B., Alsfouk, Aisha A., Metwaly, Ahmed M., Eissa, Ibrahim H.

“…A library of modified VEGFR-2 inhibitors was designed as VEGFR-2 inhibitors. Virtual screening was conducted for the hypothetical library using in silico…”
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Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico , In Vitro , and SAR Studies by Ma, Chao, Taghour, Mohammed S, Belal, Amany, Mehany, Ahmed B M, Mostafa, Naglaa, Nabeeh, Ahmed, Eissa, Ibrahim H, Al-Karmalawy, Ahmed A

“…Guided by the structural optimization principle and the promising anticancer effect of the quinoxaline nucleus, a new series of novel HDAC inhibitors were…”
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Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors by Abdallah, Abdallah E., Mabrouk, Reda R., Al Ward, Maged Mohammed Saleh, Eissa, Sally I., Elkaeed, Eslam B., Mehany, Ahmed B. M., Abo-Saif, Mariam A., El-Feky, Ola A., Alesawy, Mohamed S., El-Zahabi, Mohamed Ayman

“…Based on quinazoline, quinoxaline, and nitrobenzene scaffolds and on pharmacophoric features of VEGFR-2 inhibitors, 17 novel compounds were designed and…”
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Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies by Yousef, Reda G., Elwan, Alaa, Gobaara, Ibraheem M. M., Mehany, Ahmed B. M., Eldehna, Wagdy M., El-Metwally, Souad A., A. Alsfouk, Bshra, Elkaeed, Eslam B., Metwaly, Ahmed M., Eissa, Ibrahim H.

“…New nicotinamide derivatives 6, 7, 10, and 11 were designed and synthesised based on the essential features of the VEGFR-2 inhibitors. Compound 10 revealed the…”
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Design, Synthesis, In Silico and In Vitro Studies of New Immunomodulatory Anticancer Nicotinamide Derivatives Targeting VEGFR-2 by Yousef, Reda G., Eldehna, Wagdy M., Elwan, Alaa, Abdelaziz, Abdelaziz S., Mehany, Ahmed B. M., Gobaara, Ibraheem M. M., Alsfouk, Bshra A., Elkaeed, Eslam B., Metwaly, Ahmed M., Eissa, Ibrahim H.

“…VEGFR-2, the subtype receptor tyrosine kinase (RTK) responsible for angiogenesis, is expressed in various cancer cells. Thus, VEGFER-2 inhibition is an…”
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Biological Effect of Quercetin in Repairing Brain Damage and Cerebral Changes in Rats: Molecular Docking and In Vivo Studies by Mehany, Ahmed B. M., Belal, Amany, Santali, Eman Y., Shaaban, Salwa, Abourehab, Mohammad A. S., El-Feky, Ola A., Diab, Mahmoud, Abou Galala, Fawzy M. A., Elkaeed, Eslam B., Abdelhamid, Ghada

“…This study examined the protective effect of quercetin against high-altitude-induced brain damage in rats. A molecular docking study was performed to…”
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Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFR WT , EGFR T790M , and EGFR L858R ) by Abo Al-Hamd, Mahmoud G, Tawfik, Haytham O, Abdullah, Omeima, Yamaguchi, Koki, Sugiura, Masaharu, Mehany, Ahmed B M, El-Hamamsy, Mervat H, El-Moselhy, Tarek F

“…Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new series of anticancer agents. Thirty-two new compounds were synthesised…”
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Design, synthesis, docking study and anticancer evaluation of new trimethoxyphenyl pyridine derivatives as tubulin inhibitors and apoptosis inducers by Hagras, Mohamed, Mandour, Asmaa A, Mohamed, Esraa A, Elkaeed, Eslam B, Gobaara, Ibrahim M. M, Mehany, Ahmed B. M, Ismail, Nasser S. M, Refaat, Hanan M

“…Microtubules have become an appealing target for anticancer drug development including mainly colchicine binding site inhibitors (CBSIs). A new series of novel…”
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Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and in silico studies by Saad, Mohamed H., El-Moselhy, Tarek F., S, El-Din, Nabaweya, Mehany, Ahmed B. M., Belal, Amany, Abourehab, Mohammed A. S., Tawfik, Haytham O., El-Hamamsy, Mervat H.

“…Two new series of symmetric (1a-h) and asymmetric (2a-l) 1,4-DHP derivatives were designed, synthesised, and evaluated as anticancer agents. In vitro…”
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