Search Results - "Mehany, Ahmed"

Cetuximab Conjugated with Octreotide and Entrapped Calcium Alginate-beads for Targeting Somatostatin Receptors by Abdellatif, Ahmed A. H., Ibrahim, Mohamed A., Amin, Mohammed A., Maswadeh, Hamzah, Alwehaibi, Muhammed N., Al-Harbi, Sultan N., Alharbi, Zayed A., Mohammed, Hamdoon A., Mehany, Ahmed B. M., Saleem, Imran

“…There is a need to formulate oral cetuximab (CTX) for targeting colorectal cancer, which is reported to express somatostatin receptors (SSTRs). Therefore,…”
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Discovery of New VEGFR-2 Inhibitors: Design, Synthesis, Anti-Proliferative Evaluation, Docking, and MD Simulation Studies by Elkaeed, Eslam B, Yousef, Reda G, Khalifa, Mohamed M, Ibrahim, Albaraa, Mehany, Ahmed B M, Gobaara, Ibraheem M M, Alsfouk, Bshra A, Eldehna, Wagdy M, Metwaly, Ahmed M, Eissa, Ibrahim H, El-Zahabi, Mohamed Ayman

“…Four new nicotinamide-based derivatives were designed as antiangiogenic VEGFR-2 inhibitors. The congeners were synthesized possessing the pharmacophoric…”
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Discovery of new quinolines as potent colchicine binding site inhibitors: design, synthesis, docking studies, and anti-proliferative evaluation by Hagras, Mohamed, El Deeb, Moshira A., Elzahabi, Heba S. A., Elkaeed, Eslam B., Mehany, Ahmed B. M., Eissa, Ibrahim H.

“…Discovering of new anticancer agents with potential activity against tubulin polymerisation is still a promising approach. Colchicine binding site inhibitors…”
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Discovery of thieno[2,3-d]pyrimidine-based derivatives as potent VEGFR-2 kinase inhibitors and anti-cancer agents by El-Metwally, Souad A., Abou-El-Regal, Mohsen M., Eissa, Ibrahim H., Mehany, Ahmed B.M., Mahdy, Hazem A., Elkady, Hazem, Elwan, Alaa, Elkaeed, Eslam B.

“…[Display omitted] •Eighteen compounds of thieno[2,3-d]pyrimidine derivatives were designed and synthesized.•Anticancer activity was tested against three cancer…”
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Design, synthesis, and anti-proliferative evaluation of new quinazolin-4(3H)-ones as potential VEGFR-2 inhibitors by El-Adl, Khaled, El-Helby, Abdel-Ghany A., Ayyad, Rezk R., Mahdy, Hazem A., Khalifa, Mohamed M., Elnagar, Hamdy A., Mehany, Ahmed B.M., Metwaly, Ahmed M., Elhendawy, Mostafa A., Radwan, Mohamed M., ElSohly, Mahmoud A., Eissa, Ibrahim H.

“…[Display omitted] •Nineteen compounds of novel quinazolin-4(3H)-one derivatives were designed and synthesized.•Cytotoxic activities were evaluated against…”
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Design, synthesis, molecular modeling, in vivo studies and anticancer evaluation of quinazolin-4(3H)-one derivatives as potential VEGFR-2 inhibitors and apoptosis inducers by Mahdy, Hazem A., Ibrahim, Mohammed K., Metwaly, Ahmed M., Belal, Amany, Mehany, Ahmed B.M., El-Gamal, Kamal M.A., El-Sharkawy, Abdou, Elhendawy, Mostafa A., Radwan, Mohamed M., Elsohly, Mahmoud A., Eissa, Ibrahim H.

“…[Display omitted] •Twenty-four compounds of novel quinazolin-4(3H)-one derivatives were designed and synthesized.•Cytotoxic activities were evaluated against…”
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Design, synthesis, antiproliferative activity, molecular docking and cell cycle analysis of some novel (morpholinosulfonyl) isatins with potential EGFR inhibitory activity by Ammar, Yousry A., Sh El-Sharief, Ahmed M., Belal, Amany, Abbas, Samir Y., Mohamed, Yehia A., Mehany, Ahmed B.M., Ragab, Ahmed

“…New series of 5-(morpholinosulfonyl) isatin derivatives were designed and synthesized. The new compounds were characterized on the basis of spectral and…”
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Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors by Belal, Amany, Abdel Gawad, Nagwa M., Mehany, Ahmed B. M., Abourehab, Mohammed A. S., Elkady, Hazem, Al-Karmalawy, Ahmed A., Ismael, Ahmed S.

“…A new series of 1H-pyrrole (6a-c, 8a-c), pyrrolo[3,2-d]pyrimidines (9a-c) and pyrrolo[3,2-e][1, 4]diazepines (11a-c) were designed and synthesised. These…”
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Discovery of Some Heterocyclic Molecules as Bone Morphogenetic Protein 2 (BMP-2)-Inducible Kinase Inhibitors: Virtual Screening, ADME Properties, and Molecular Docking Simulations by Belal, Amany, Elkady, Hazem, Al-Karmalawy, Ahmed A, Amin, Ali H, Ghoneim, Mohammed M, El-Sherbiny, Mohamed, Al-Serwi, Rasha Hamed, Abdou, Mohamed Attia, Ibrahim, Mona H, Mehany, Ahmed B. M

“…Bone morphogenetic proteins (BMPs) are growth factors that have a vital role in the production of bone, cartilage, ligaments, and tendons. Tumors’ upregulation…”
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Apoptotic and anti-angiogenic effects of propolis against human bladder cancer: molecular docking and in vitro screening by Mehany, Ahmed B. M., Belal, Amany, Mohamed, Aly Fahmy, Shaaban, Salwa, Abdelhamid, Ghada

“…Bladder cancer is still of unknown initiation and progression, it is difficult to treat the patient once bladder cancer have a distant metastasis. In the…”
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Discovery of new quinoxaline-2(1H)-one-based anticancer agents targeting VEGFR-2 as inhibitors: Design, synthesis, and anti-proliferative evaluation by El-Adl, Khaled, Sakr, Helmy M., Yousef, Reda G., Mehany, Ahmed B.M., Metwaly, Ahmed M., Elhendawy, Mostafa A., Radwan, Mohamed M., ElSohly, Mahmoud A., Abulkhair, Hamada S., Eissa, Ibrahim H.

“…[Display omitted] •New quinoxaline-2(1H)-one-based derivatives incorporating amide linker moieties were designed and synthesized.•Cytotoxic activities were…”
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Design, molecular docking, in vitro, and in vivo studies of new quinazolin-4(3H)-ones as VEGFR-2 inhibitors with potential activity against hepatocellular carcinoma by Eissa, Ibrahim.H., Ibrahim, Mohammed K., Metwaly, Ahmed M., Belal, Amany, Mehany, Ahmed B.M., Abdelhady, Alsayed A., Elhendawy, Mostafa A., Radwan, Mohamed M., ElSohly, Mahmoud A., Mahdy, Hazem A.

“…[Display omitted] •Seventeen compounds of novel quinazolin-4(3H)-one derivatives were designed and synthesized.•Cytotoxic activities were evaluated against…”
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Phytochemical Profiling, In Vitro and In Silico Anti-Microbial and Anti-Cancer Activity Evaluations and Staph GyraseB and h -TOP-IIβ Receptor-Docking Studies of Major Constituents of Zygophyllum coccineum L. Aqueous-Ethanolic Extract and Its Subsequent Fractions: An Approach to Validate Traditional Phytomedicinal Knowledge by Mohammed, Hamdoon A, Khan, Riaz A, Abdel-Hafez, Atef A, Abdel-Aziz, Marwa, Ahmed, Eman, Enany, Shymaa, Mahgoub, Sebaey, Al-Rugaie, Osamah, Alsharidah, Mansour, Aly, Mohamed S A, Mehany, Ahmed B M, Hegazy, Mostafa M

“…, an edible halophytic plant, is part of the traditional medicine chest in the Mediterranean region for symptomatic relief of diabetes, hypertension, wound…”
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Modified Benzoxazole-Based VEGFR-2 Inhibitors and Apoptosis Inducers: Design, Synthesis, and Anti-Proliferative Evaluation by Elwan, Alaa, Abdallah, Abdallah E, Mahdy, Hazem A, Dahab, Mohammed A, Taghour, Mohammed S, Elkaeed, Eslam B, Mehany, Ahmed B M, Nabeeh, Ahmed, Adel, Mohammed, Alsfouk, Aisha A, Elkady, Hazem, Eissa, Ibrahim H

“…This work is one of our efforts to discover potent anticancer agents. We modified the most promising derivative of our previous work concerned with the…”
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Design, synthesis, antiproliferative evaluation, and molecular docking study of new quinoxaline derivatives as apoptotic inducers and EGFR inhibitors by Fayed, Eman A., Ammar, Yousry A., Saleh, Marwa A., Bayoumi, Ashraf H., Belal, Amany, Mehany, Ahmed B.M., Ragab, Ahmed

“…•A series of new quinoxaline derivatives were designed and synthesized.•Cytotoxic evaluation and SAR study of the new quinoxaline derivatives are…”
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Design, synthesis, biological evaluation and molecular modeling of new coumarin derivatives as potent anticancer agents by Fayed, Eman A., Sabour, Rehab, Harras, Marwa F., Mehany, Ahmed B. M.

“…A novel series of coumarin-pyridine/fused pyridine hybrids were designed and synthesized. Their anticancer activity was evaluated against human cancer cell…”
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Screening a Panel of Topical Ophthalmic Medications against MMP-2 and MMP-9 to Investigate Their Potential in Keratoconus Management by Belal, Amany, Elanany, Mohamed A, Santali, Eman Y, Al-Karmalawy, Ahmed A, Aboelez, Moustafa O, Amin, Ali H, Abdellattif, Magda H, Mehany, Ahmed B M, Elkady, Hazem

“…Keratoconus (KC) is a serious disease that can affect people of any race or nationality, although the exact etiology and pathogenic mechanism are still…”
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Antitrypanosomal, Antitopoisomerase-I, and Cytotoxic Biological Evaluation of Some African Plants Belonging to Crassulaceae; Chemical Profiling of Extract Using UHPLC/QTOF-MS/MS by Hegazy, Mostafa M, Afifi, Wael M, Metwaly, Ahmed M, Radwan, Mohamed M, Abd-Elraouf, Muhamad, Mehany, Ahmed B M, Ahmed, Eman, Enany, Shymaa, Ezzeldin, Shahd, Ibrahim, Adel E, El Deeb, Sami, Mostafa, Ahmad E

“…In our continuous study for some African plants as a source for antitrypanosomally and cytotoxic active drugs, nine different plants belonging to the…”
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Discovery of new nicotinamides as apoptotic VEGFR-2 inhibitors: virtual screening, synthesis, anti-proliferative, immunomodulatory, ADMET, toxicity, and molecular dynamic simulation studies by Yousef, Reda G., Ibrahim, Albaraa, Khalifa, Mohamed M., Eldehna, Wagdy M., Gobaara, Ibraheem M. M., Mehany, Ahmed B. M., Elkaeed, Eslam B., Alsfouk, Aisha A., Metwaly, Ahmed M., Eissa, Ibrahim H.

“…A library of modified VEGFR-2 inhibitors was designed as VEGFR-2 inhibitors. Virtual screening was conducted for the hypothetical library using in silico…”
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In vitro cytotoxic activity of thiazole-indenoquinoxaline hybrids as apoptotic agents, design, synthesis, physicochemical and pharmacokinetic studies by Fayed, Eman A., Ammar, Yousry A., Ragab, Ahmed, Gohar, Nirvana A., Mehany, Ahmed B.M., Farrag, Amel M.

“…In silico assessment of all the potent compounds pharmacokinetic, drug-likeness and PAINS alerts profiles was performed. [Display omitted] •Novel 25…”
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