Very-early-onset inflammatory bowel disease versus late-onset inflammatory bowel disease in relation to clinical phenotype: A cross-sectional study
Background Inflammatory bowel disease (IBD) is a chronic condition and children are affected by the disease’s burden and therapeutic interventions for much longer than adults. Children of various ages can be diagnosed with IBD. Methods The research was carried out at the Pediatric Gastroenterology C...
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| Published in: | Indian journal of gastroenterology Vol. 42; no. 2; pp. 185 - 191 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
New Delhi
Springer India
01-04-2023
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Background
Inflammatory bowel disease (IBD) is a chronic condition and children are affected by the disease’s burden and therapeutic interventions for much longer than adults. Children of various ages can be diagnosed with IBD.
Methods
The research was carried out at the Pediatric Gastroenterology Clinic at Cairo University’s Faculty of Medicine’s Children’s Hospital. From January 2013 to December 2017, this single-center observational cross-sectional study included 197 children aged 14 years and compared the clinical phenotypes of very-early-onset IBD (VEO-IBD) in patients aged six years and late-onset IBD (LO-IBD) in patients aged six to 14 years.
Results
Children with IBD at less than six years of age have a more colonic phenotype than children diagnosed later in life, who are more likely to have ileocolonic diseases (
p
= 0.002). In VEO-disease Crohn’s (VEO-CD), growth failure/poor weight gain was 14%, while in LO-CD, it was 31%. Children with VEO-IBD do not always present with more severe disease than older children. Most clinical features in children with VEO-ulcerative colitis (VEO-UC) and LO-UC were similar at the first presentation, with the exception of abdominal pain, which was significantly less common in the VEO-UC group (
p
= 0.001) and hematochezia, which was significantly more common in the LO-UC group (
p
= 0.048). Children with VEO-disease Crohn’s (VEO-CD) had a higher risk of bloody stools, diarrhea and fever (
p
= 0.013,
p
= 0.001 and
p
= 0.008, respectively), but a lower risk of abdominal pain (
p
= 0.000).
Conclusions
Growth failure/poor weight gain occurred in 14% of VEO-CD patients and 31% of LO-CD patients. In LO-UC, abdominal pain and hematochezia were significantly more common. In LO-CD, hematochezia, diarrhea and fever were significantly more common. In LO-IBD-U, abdominal pain and diarrhea were significantly more common. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 |
| ISSN: | 0254-8860 0975-0711 |
| DOI: | 10.1007/s12664-022-01318-4 |