Search Results - "Megson, I. L"

Recent developments in nitric oxide donor drugs by Miller, M R, Megson, I L

“…During the 1980s, the free radical, nitric oxide (NO), was discovered to be a crucial signalling molecule, with wide‐ranging functions in the cardiovascular,…”
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Acute Cardiovascular Effects of Apelin in Humans Potential Role in Patients With Chronic Heart Failure by JAPP, A. G, CRUDEN, N. L, NEWBY, D. E, BARNES, G, VAN GEMEREN, N, MATHEWS, J, ADAMSON, J, JOHNSTON, N. R, DENVIR, M. A, MEGSON, I. L, FLAPAN, A. D

“…Apelin, the endogenous ligand for the novel G protein-coupled receptor APJ, has major cardiovascular effects in preclinical models. The study objectives were…”
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NiO and Co3O4 nanoparticles induce lung DTH-like responses and alveolar lipoproteinosis by CHO, W.-S, DUFFIN, R, BRADLEY, M, MEGSON, I. L, MACNEE, W, HOWIE, S. E. M, DONALDSON, K

“…Lung exposure to metal oxide nanoparticles (NPs) comprising soluble metal haptens may produce T-helper cell type 1 (Th1)- and Th17-associated delayed-type…”
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N-Acetylcysteine inhibits platelet–monocyte conjugation in patients with type 2 diabetes with depleted intraplatelet glutathione: a randomised controlled trial by Treweeke, A. T., Winterburn, T. J., Mackenzie, I., Barrett, F., Barr, C., Rushworth, G. F., Dransfield, I., MacRury, S. M., Megson, I. L.

“…Aims/hypothesis The aim of this study was to determine whether oral dosing with N -acetylcysteine (NAC) increases intraplatelet levels of the antioxidant,…”
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Preliminary study of hypoxia-related cardiovascular mediator-markers in patients with end-stage renal disease with and without diabetes and the effects of haemodialysis by Treweeke, A, Hall, J, Lambie, S, Leslie, S J, Megson, I L, MacRury, S M

“…Evidence points to activation of pro-inflammatory and pro-thrombotic stimuli during the haemodialysis process in end-stage renal disease (ESRD) with potential…”
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A randomized crossover study to assess the effect of an oat-rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes by McGeoch, S. C., Johnstone, A. M., Lobley, G. E., Adamson, J., Hickson, K., Holtrop, G., Fyfe, C., Clark, L. F., Pearson, D. W. M., Abraham, P., Megson, I. L., MacRury, S. M.

“…Aims In the UK, lifestyle intervention is first‐line management in Type 2 diabetes. It is unclear what type of diet is most efficacious for improving glycaemic…”
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Nitric oxide: a key regulator of myeloid inflammatory cell apoptosis by Taylor, E L, Megson, I L, Haslett, C, Rossi, A G

“…Apoptosis of inflammatory cells is a critical event in the resolution of inflammation, as failure to undergo this form of cell death leads to increased tissue…”
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Ruthenium complexes as nitric oxide scavengers: a potential therapeutic approach to nitric oxide‐mediated diseases by Fricker, S. P., Slade, Elizabeth, Powell, N. A., Vaughan, O. J., Henderson, G. R., Murrer, B. A., Megson, I. L., Bisland, S. K., Flitney, F. W.

“…1 Ruthenium(III) reacts with nitric oxide (NO) to form stable ruthenium(II) mononitrosyls. Several Ru(III) complexes were synthesized and a study made of their…”
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Co-ingestion of antioxidant drinks with an unhealthy challenge meal fails to prevent post-prandial endothelial dysfunction: an open-label, crossover study in healthy older adults by Goszcz, K., Muggeridge, D. J., Treweeke, A., Adamson, J., Hickson, K., Megson, I. L.

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Inhibition of Human Platelet Aggregation by Nitric Oxide Donor Drugs: Relative Contribution of cGMP-Independent Mechanisms by Sogo, Naoki, Magid, Kesson S., Shaw, Catherine A., Webb, David J., Megson, Ian L.

“…Inhibition of platelet activation by nitric oxide (NO) is not exclusively cGMP-dependent. Here, we tested whether inhibition of platelet aggregation by…”
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Inducible nitric oxide synthase‐derived superoxide contributes to hypereactivity in small mesenteric arteries from a rat model of chronic heart failure by Miller, Alyson A, Megson, Ian L, Gray, Gillian A

“…The aims of this study were to (a) determine whether inducible nitric oxide synthase (iNOS) is expressed in small mesenteric arteries from rats with chronic…”
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Selective modifiers of glutathione biosynthesis and ‘repriming’ of vascular smooth muscle photorelaxation by Megson, I L, Holmes, Sally A, Magid, K S, Pritchard, Rebecca J, Flitney, F W

“…Photorelaxation of vascular smooth muscle (VSM) is caused by the release of nitric oxide (NO) from a finite molecular store that can be depleted by irradiating…”
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Neocuproine, a selective Cu(I) chelator, and the relaxation of rat vascular smooth muscle by S‐nitrosothiols by Al‐Sa'doni, H H, Megson, I L, Bisland, S, Butler, A R, Flitney, F W

“…A study has been made of the effect of neocuproine, a specific Cu(I) chelator, on vasodilator responses of rat isolated perfused tail artery to two…”
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N‐substituted analogues of S‐nitroso‐N‐acetyl‐D,L‐penicillamine: chemical stability and prolonged nitric oxide mediated vasodilatation in isolated rat femoral arteries by Megson, I L, Morton, S, Greig, I R, Mazzei, F A, Field, R A, Butler, A R, Caron, G, Gasco, A, Fruttero, R, Webb, D J

“…Previous studies show that linking acetylated glucosamine to S‐nitroso‐N‐acetyl‐D,L‐penicillamine (SNAP) stabilizes the molecule and causes it to elicit…”
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Extracellular Nitric Oxide Release Mediates Soluble Guanylate Cyclase-Independent Vasodilator Action of Spermine NONOate: Comparison with Other Nitric Oxide Donors in Isolated Rat Femoral Arteries by Miller, M. R, Okubo, K, Roseberry, M. J, Webb, D. J, Megson, I. L

“…Nitric oxide (NO) and NO donors exhibit actions that are not entirely mediated by soluble guanylate cyclase (sGC). The site of NO release may influence the…”
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Prolonged effect of a novel S‐nitrosated glyco‐amino acid in endothelium‐denuded rat femoral arteries: potential as a slow release nitric oxide donor drug by Megson, I. L., Greig, I. R., Gray, G. A., Webb, D. J., Butler, A. R.

“…1 The vasodilator properties of a novel S‐nitrosated glyco‐amino acid (RIG200) were investigated in isolated rat femoral arteries and compared with those of…”
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Vasodilator responses of rat isolated tail artery enhanced by oxygen‐dependent, photochemical release of nitric oxide from iron‐sulphur‐nitrosyls by Flitney, F.W., Megson, I.L., Thomson, Joanne L.M., Kennovin, G.D., Butler, A.R.

“…1 The vasodilator properties and photochemical decomposition of two synthetic iron‐sulphur‐nitrosyl clusters (cluster A: [Fe4S4(NO)4],…”
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Nitrate resistance in platelets from patients with stable angina pectoris by Megson, I L, Webb, D J

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Oral vitamin C reduces arterial stiffness and platelet aggregation in humans by WILKINSON, I. B, MEGSON, I. L, MACCALLUM, H, SOGO, N, COCKCROFT, J. R, WEBB, D. J

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Glutathione supplementation to University of Wisconsin solution causes endothelial dysfunction by Tambyraja, A.L, Mitchell, R, Driscoll, P.J, Deans, C, Parks, R.W, Rahman, I, Megson, I.L

“…Abstract Introduction Glutathione (GSH) is added to University of Wisconsin (UW) organ preservation solution to protect against oxidative stress. This study…”
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