Search Results - "Megosh, L"

Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin by O'BRIEN, T. G, MEGOSH, L. C, GILLIARD, G, PERALTA SOLER, A

“…In multistage tumorigenesis models, ornithine decarboxylase (ODC) is usually dysregulated at some point during tumor promotion, an early stage of…”
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K6/ODC transgenic mice as a sensitive model for carcinogen identification by Chen, Yan, Megosh, Louis C, Gilmour, Susan K, Sawicki, Janet A, O’Brien, Thomas G

“…Ornithine decarboxylase (ODC), an important enzyme in the polyamine biosynthetic pathway, is aberrantly regulated in many epithelial tumors of rodents and…”
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Constitutively elevated levels of ornithine and polyamines in mouse epidermal papillomas by Koza, R A, Megosh, L C, Palmieri, M, O'Brien, T G

“…Epidermal papillomas were induced in CD-1 mice by a single topical application of 7,12-dimethylbenzanthracene (DMBA) followed by twice weekly applications of…”
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Genetic Control of Polyamine-Dependent Susceptibility to Skin Tumorigenesis by Megosh, Louis C., Hu, Juncai, George, Ken, O'Brien, Thomas G.

“…Overexpression of an ornithine decarboxylase (ODC) transgene greatly increases the susceptibility of mouse skin to carcinogen-induced tumor development. Like…”
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Polyamines regulate expression of the neoplastic phenotype in mouse skin by PERALTA SOLER, A, GILLIARD, G, MEGOSH, L, GEORGE, K, O'BRIEN, T. G

“…Elevated polyamine levels are characteristic of many types of neoplastic cells and tissues. We demonstrate that in transgenic mice overexpressing ornithine…”
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Increased frequency of spontaneous skin tumors in transgenic mice which overexpress ornithine decarboxylase by MEGOSH, L, GILMOUR, S. K, ROSSON, D, SOLER, A. P, BLESSING, M, SAWICKI, J. A, O'BRIEN, T. G

“…Ornithine decarboxylase, a critical regulatory enzyme for polyamine biosynthesis, is highly inducible by growth-promoting stimuli in mouse epidermis but the…”
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Modulation of Murine Hair Follicle Function by Alterations in Ornithine Decarboxylase Activity by Soler, Alejandro Peralta, Gilliard, Gwendolyn, Megosh, Louis C., O'Brien, Thomas G.

“…Mice that overexpress a mutated ornithine decarboxylase (ODC) transgene in outer root sheath keratinocytes of the hair follicle were used to study the role of…”
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Targeted expression of spermidine/spermine N super(1)-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis by Coleman, C S, Pegg, A E, Megosh, L C, Guo, Y, Sawicki, JA, O'Brien, T G

“…The bovine keratin 6 gene promoter was used to target expression of spermidine/spermine N super(1)-acetyltransferase (SSAT) to epidermal keratinocytes in the…”
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An Essential Role for an Inositol Polyphosphate Multikinase, Ipk2, in Mouse Embryogenesis and Second Messenger Production by Frederick, Joshua P., Mattiske, Deidre, Wofford, Jessica A., Megosh, Louis C., Drake, Li Yin, Chiou, Shean-Tai, Brigid L. M. Hogan, York, John D., Majerus, Philip W.

“…Phospholipase C and several inositol polyphosphate kinase (IPK) activities generate a branched ensemble of inositol polyphosphate second messengers that…”
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Analysis of ras gene mutational spectra in epidermal papillomas from K6/ODC transgenic mice by Megosh, Louis, Halpern, Matthew, Farkash, Evan, O'Brien, Thomas G.

“…In standard mouse strains, a high proportion (more than 90%) of epidermal tumors produced by initiation with 7,12‐dimethylbenz[a]anthracene and promotion with…”
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Induction of ornithine decarboxylase in specific subpopulations of murine epidermal cells following multiple exposures to 12-O-tetradecanoylphorbol-13-acetate, mezerein and ethyl phenylpropriolate by Gilmour, S K, Robertson, F M, Megosh, L, O'Connell, S M, Mitchell, J, O'Brien, T G

“…Single applications of 12-O-tetradecanoylphorbol-13-acetate (TPA), mezerein or ethyl phenylpropriolate (EPP) to mouse skin at appropriate doses cause similar…”
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