Search Results - "Meglio, Paola Di"

The Aryl Hydrocarbon Receptor: Multitasking in the Immune System by Stockinger, Brigitta, Meglio, Paola Di, Gialitakis, Manolis, Duarte, João H

“…The aryl hydrocarbon receptor (AhR), for many years almost exclusively studied by the pharmacology/toxicology field for its role in mediating the toxicity of…”
Get full text

The Genetic Architecture of the Human Immune System: A Bioresource for Autoimmunity and Disease Pathogenesis by Roederer, Mario, Quaye, Lydia, Mangino, Massimo, Beddall, Margaret H., Mahnke, Yolanda, Chattopadhyay, Pratip, Tosi, Isabella, Napolitano, Luca, Terranova Barberio, Manuela, Menni, Cristina, Villanova, Federica, Di Meglio, Paola, Spector, Tim D., Nestle, Frank O.

“…Despite recent discoveries of genetic variants associated with autoimmunity and infection, genetic control of the human immune system during homeostasis is…”
Get full text

Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions by Di Meglio, Paola, Duarte, João H., Ahlfors, Helena, Owens, Nick D.L., Li, Ying, Villanova, Federica, Tosi, Isabella, Hirota, Keiji, Nestle, Frank O., Mrowietz, Ulrich, Gilchrist, Michael J., Stockinger, Brigitta

“…Environmental stimuli are known to contribute to psoriasis pathogenesis and that of other autoimmune diseases, but the mechanisms are largely unknown. Here we…”
Get full text

Mutations in IL36RN/IL1F5 Are Associated with the Severe Episodic Inflammatory Skin Disease Known as Generalized Pustular Psoriasis by Onoufriadis, Alexandros, Simpson, Michael A., Pink, Andrew E., Di Meglio, Paola, Smith, Catherine H., Pullabhatla, Venu, Knight, Jo, Spain, Sarah L., Nestle, Frank O., Burden, A. David, Capon, Francesca, Trembath, Richard C., Barker, Jonathan N.

“…Generalized pustular psoriasis (GPP) is a rare and yet potentially lethal clinical variant of psoriasis, characterized by the formation of sterile cutaneous…”
Get full text

Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis by Andres-Ejarque, Rosa, Ale, Hira Bahadur, Grys, Katarzyna, Tosi, Isabella, Solanky, Shane, Ainali, Chrysanthi, Catak, Zeynep, Sreeneebus, Hemawtee, Saklatvala, Jake, Dand, Nick, de Rinaldis, Emanuele, Chapman, Anna, Nestle, Frank O., Barnes, Michael R., Warren, Richard B., Reynolds, Nick J., Griffiths, Christopher E. M., Barker, Jonathan N., Smith, Catherine H., Di Meglio, Paola

“…Biologic therapies have transformed the management of psoriasis, but clinical outcome is variable leaving an unmet clinical need for predictive biomarkers of…”
Get full text

A Role for Th17 Cells in the Immunopathogenesis of Atopic Dermatitis? by Cesare, Antonella Di, Meglio, Paola Di, Nestle, Frank O.

“…Atopic dermatitis (AD) is a common inflammatory skin disease. Both epidermal barrier dysfunction and immunodysregulation are suggested to influence the…”
Get full text

Author Correction: Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis by Andres-Ejarque, Rosa, Ale, Hira Bahadur, Grys, Katarzyna, Tosi, Isabella, Solanky, Shane, Ainali, Chrysanthi, Catak, Zeynep, Sreeneebus, Hemawtee, Saklatvala, Jake, Dand, Nick, de Rinaldis, Emanuele, Chapman, Anna, Nestle, Frank O., Barnes, Michael R., Warren, Richard B., Reynolds, Nick J., Griffiths, Christopher E. M., Barker, Jonathan N., Smith, Catherine H., Di Meglio, Paola

Get full text

The role of IL-23 in the immunopathogenesis of psoriasis by Di Meglio, Paola, Nestle, Frank O

“…In just 10 years from its discovery in 2000, interleukin-23 has quickly moved from being recognized as a pro-inflammatory cytokine to a key player and…”
Get full text

The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis by Di Cesare, Antonella, Di Meglio, Paola, Nestle, Frank O.

“…Abnormal production of inflammatory mediators is believed to play an important role in the pathogenesis of psoriasis. Emerging data, both in mice and in…”
Get full text

Psoriasis by Perera, Gayathri K, Di Meglio, Paola, Nestle, Frank O

“…Psoriasis is a common relapsing and remitting immune-mediated inflammatory disease that affects the skin and joints. This review focuses on current…”
Get full text

Characterization of Innate Lymphoid Cells in Human Skin and Blood Demonstrates Increase of NKp44+ ILC3 in Psoriasis by Villanova, Federica, Flutter, Barry, Tosi, Isabella, Grys, Katarzyna, Sreeneebus, Hemawtee, Perera, Gayathri K., Chapman, Anna, Smith, Catherine H., Di Meglio, Paola, Nestle, Frank O.

“…Innate lymphoid cells (ILCs) are increasingly appreciated as key regulators of tissue immunity. However, their role in human tissue homeostasis and disease…”
Get full text

The Multitasking Organ: Recent Insights into Skin Immune Function by Di Meglio, Paola, Perera, Gayathri K., Nestle, Frank O.

“…The skin provides the first line defense of the human body against injury and infection. By integrating recent findings in cutaneous immunology with…”
Get full text

HLA-C06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis by Dand, Nick, Duckworth, Michael, Baudry, David, Russell, Alice, Curtis, Charles J., Lee, Sang Hyuck, Evans, Ian, Mason, Kayleigh J., Alsharqi, Ali, Becher, Gabrielle, Burden, A. David, Goodwin, Richard G., McKenna, Kevin, Murphy, Ruth, Perera, Gayathri K., Rotarescu, Radu, Wahie, Shyamal, Wright, Andrew, Reynolds, Nick J., Warren, Richard B., Griffiths, Christopher E.M., Smith, Catherine H., Simpson, Michael A., Barker, Jonathan N., Benham, Marilyn, Hussain, Sagair, Kirby, Brian, Lawson, Linda, McElhone, Kathleen, Ormerod, Anthony, Owen, Caroline, Barnes, Michael R., Di Meglio, Paola, Emsley, Richard, Evans, Andrea, Payne, Katherine, Stocken, Deborah

“…Biologic therapies can be highly effective for the treatment of severe psoriasis, but response for individual patients can vary according to drug. Predictive…”
Get full text

Targeting CD8+ T cells prevents psoriasis development by Di Meglio, Paola, PhD, Villanova, Federica, PhD, Navarini, Alexander A., MD, PhD, Mylonas, Alessio, MSc, Tosi, Isabella, MSc, Nestle, Frank O., MD, Conrad, Curdin, MD

“…Importantly, in the absence of T-cell expansion upon transplantation, which did not occur in one of the experiments we performed, we did not observe any…”
Get full text

Mapping cis- and trans-regulatory effects across multiple tissues in twins by Grundberg, Elin, Small, Kerrin S, Hedman, Åsa K, Nica, Alexandra C, Buil, Alfonso, Keildson, Sarah, Bell, Jordana T, Yang, Tsun-Po, Meduri, Eshwar, Barrett, Amy, Nisbett, James, Sekowska, Magdalena, Wilk, Alicja, Shin, So-Youn, Glass, Daniel, Travers, Mary, Min, Josine L, Ring, Sue, Ho, Karen, Thorleifsson, Gudmar, Kong, Augustine, Thorsteindottir, Unnur, Ainali, Chrysanthi, Dimas, Antigone S, Hassanali, Neelam, Ingle, Catherine, Knowles, David, Krestyaninova, Maria, Lowe, Christopher E, Di Meglio, Paola, Montgomery, Stephen B, Parts, Leopold, Potter, Simon, Surdulescu, Gabriela, Tsaprouni, Loukia, Tsoka, Sophia, Bataille, Veronique, Durbin, Richard, Nestle, Frank O, O'Rahilly, Stephen, Soranzo, Nicole, Lindgren, Cecilia M, Zondervan, Krina T, Ahmadi, Kourosh R, Schadt, Eric E, Stefansson, Kari, Smith, George Davey, McCarthy, Mark I, Deloukas, Panos, Dermitzakis, Emmanouil T, Spector, Tim D

“…The MuTHER Consortium reports an analysis of the genetics of gene expression in three tissues from approximately 850 mono- and dizygotic twins. They…”
Get full text

Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo by Duarte, João H, Di Meglio, Paola, Hirota, Keiji, Ahlfors, Helena, Stockinger, Brigitta

“…The aryl hydrocarbon receptor (AhR) has been attributed with anti-inflammatory effects in the development of pathological immune responses leading to…”
Get full text

IL-22 fate reporter reveals origin and control of IL-22 production in homeostasis and infection by Ahlfors, Helena, Morrison, Peter J, Duarte, João H, Li, Ying, Biro, Judit, Tolaini, Mauro, Di Meglio, Paola, Potocnik, Alexandre J, Stockinger, Brigitta

“…IL-22 is a cytokine that regulates tissue homeostasis at barrier surfaces. A variety of IL-22-producing cell types is known, but identification on the…”
Get full text

Gene expression changes with age in skin, adipose tissue, blood and brain by Glass, Daniel, Viñuela, Ana, Davies, Matthew N, Ramasamy, Adaikalavan, Parts, Leopold, Knowles, David, Brown, Andrew A, Hedman, Asa K, Small, Kerrin S, Buil, Alfonso, Grundberg, Elin, Nica, Alexandra C, Di Meglio, Paola, Nestle, Frank O, Ryten, Mina, Durbin, Richard, McCarthy, Mark I, Deloukas, Panagiotis, Dermitzakis, Emmanouil T, Weale, Michael E, Bataille, Veronique, Spector, Tim D

“…Previous studies have demonstrated that gene expression levels change with age. These changes are hypothesized to influence the aging rate of an individual. We…”
Get full text

Biomarkers of disease progression in people with psoriasis: a scoping review by Ramessur, Ravi, Corbett, Mark, Marshall, David, Acencio, Marcio L., Barbosa, Ines A., Dand, Nick, Di Meglio, Paola, Haddad, Salma, Jensen, Andreas H.M., Koopmann, Witte, Mahil, Satveer K., Ostaszewski, Marek, Rahmatulla, Seher, Rastrick, Joe, Saklatvala, Jake, Weidinger, Stephan, Wright, Kath, Eyerich, Kilian, Ndlovu, Matladi, Barker, Jonathan N., Skov, Lone, Conrad, Curdin, Smith, Catherine H

“…Background Identification of those at risk of more severe psoriasis and/or associated morbidities offers opportunity for early intervention, reduced disease…”
Get full text

The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans by Di Meglio, Paola, Di Cesare, Antonella, Laggner, Ute, Chu, Chung-Ching, Napolitano, Luca, Villanova, Federica, Tosi, Isabella, Capon, Francesca, Trembath, Richard C, Peris, Ketty, Nestle, Frank O

“…IL-23 and Th17 cells are key players in tissue immunosurveillance and are implicated in human immune-mediated diseases. Genome-wide association studies have…”
Get full text