Search Results - "Megill, John R."

Permeability Characteristics of Calu-3 Human Bronchial Epithelial Cells: In Vitro - In Vivo Correlation to Predict Lung Absorption in Rats by Mathias, Neil R., Timoszyk, Julita, Stetsko, Paul I., Megill, John R., Smith, Ronald L., Wall, Doris A.

“…The goal of this study was to evaluate the permeability characteristics of Calu-3, human bronchial epithelial cells to passive and actively transported drugs…”
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Cannabinoid receptor antagonist-induced striated muscle toxicity and ethylmalonic-adipic aciduria in beagle dogs by Tomlinson, Lindsay, Tirmenstein, Mark A, Janovitz, Evan B, Aranibar, Nelly, Ott, Karl-Heinz, Kozlosky, John C, Patrone, Laura M, Achanzar, William E, Augustine, Karen A, Brannen, Kimberly C, Carlson, Kenneth E, Charlap, Jeffrey H, Dubrow, Katherine M, Kang, Liya, Rosini, Laura T, Panzica-Kelly, Julieta M, Flint, Oliver P, Moulin, Frederic J, Megill, John R, Zhang, Haiying, Bennett, Michael J, Horvath, Joseph J

“…Ibipinabant (IBI), a potent cannabinoid-1 receptor (CB1R) antagonist, previously in development for the treatment of obesity, causes skeletal and cardiac…”
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From the Cover: Investigative Nonclinical Cardiovascular Safety and Toxicology Studies with BMS-986094, an NS5b RNA-Dependent RNA Polymerase Inhibitor by Gill, Michael, Horn, Kristen, Hennan, James, White, Randy, Bounous, Denise, Clark, Shawn, Megill, John R, Janovitz, Evan, Davies, Marc, Sanderson, Thomas, Graziano, Michael

“…BMS-986094, a 2'-C-methylguanosine prodrug that was in development for treatment of chronic hepatitis C infection was withdrawn from Phase 2 clinical trials…”
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Mechanisms for Hepatobiliary Toxicity in Rats Treated with an Antagonist of Melanin Concentrating Hormone Receptor 1 (MCHR1) by Otieno, Monicah A, Bhaskaran, Vasanthi, Janovitz, Evan, Callejas, Yimer, Foster, William B, Washburn, William, Megill, John R, Lehman-McKeeman, Lois, Gemzik, Brian

“…The objective of this work was to investigate the mechanisms of hepatobiliary toxicity caused by thienopyrimidone MCHR1 antagonists using BMS-773174 as a tool…”
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Scientific and Regulatory Policy Committee Points to Consider: Review of Scientific and Regulatory Policy Committee Points to Consider: Review of Current Practices for Ultrastructural Pathology Evaluations in Support of Nonclinical Toxicology Studies by Keirstead, Natalie D., Janovitz, Evan B., Meehan, James T., LeRoy, Bruce E., Megill, John R., Peterson, Richard A., Masson, Regis G., Marxfeld, Heike A.

“…Anatomic pathology and clinical pathology end points are standard components of almost every nonclinical general toxicity study conducted during the risk…”
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Glucokinase regulatory protein may interact with glucokinase in the hepatocyte nucleus by BROWN, K. S, KALINOWSKI, S. S, MEGILL, J. R, DURHAM, S. K, MOOKHTIAR, K. A

“…Glucokinase (GK) plays a central role in the sensing of glucose in pancreatic beta-cells and parenchymal cells of the liver. Glucokinase regulatory protein is…”
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Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1 by Fuentes, ME, Durham, SK, Swerdel, MR, Lewin, AC, Barton, DS, Megill, JR, Bravo, R, Lira, SA

“…Transgenic mice overexpressing the chemokine monocyte chemoattractant protein-1 (MCP-1) in the thymus and central nervous system have a higher number of…”
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Effects of endothelin in radiocontrast-induced nephropathy in rats are mediated through endothelin-A receptors by Bird, J E, Giancarli, M R, Megill, J R, Durham, S K

“…A role for endothelin in the pathogenesis of radiocontrast-induced nephropathy has been suggested by several studies, but the specific contributions of…”
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A ferret model of electrical-induction of arterial thrombosis that is sensitive to aspirin by Schumacher, William A., Steinbacher, Thomas E., Megill, John R., Durham, Stephen K.

“…An experimental model of acute thrombosis was developed in pentobarbital-anesthetized ferrets. A 10-min anodal electrical stimulation of 1 mA was delivered to…”
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Granule cells in the rat olfactory tubercle accumulate 3H-gamma-aminobutyric acid by Krieger, N R, Megill, J R, Sterling, P

“…The rat olfactory tubercle contains high concentrations of gamma-aminobutyric acid (GABA) and its synthetic enzyme, glutamic acid decarboxylase (GAD). We…”
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