Search Results - "Mege, Jean Louis"

Staphylococcus aureus Nasal Colonization: An Update on Mechanisms, Epidemiology, Risk Factors, and Subsequent Infections by Sakr, Adèle, Brégeon, Fabienne, Mège, Jean-Louis, Rolain, Jean-Marc, Blin, Olivier

“…Up to 30% of the human population are asymptomatically and permanently colonized with nasal . To successfully colonize human nares, needs to establish solid…”
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From Q Fever to Coxiella burnetii Infection: a Paradigm Change by Eldin, Carole, Mélenotte, Cléa, Mediannikov, Oleg, Ghigo, Eric, Million, Matthieu, Edouard, Sophie, Mege, Jean-Louis, Maurin, Max, Raoult, Didier

“…Coxiella burnetii is the agent of Q fever, or "query fever," a zoonosis first described in Australia in 1937. Since this first description, knowledge about…”
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Changing the paradigm of IFN‐γ at the interface between innate and adaptive immunity: Macrophage‐derived IFN‐γ by Mezouar, Soraya, Mege, Jean‐Louis

“…IFN‐γ plays a critical role in the immune response to bacterial infections. It is established that IFN‐γ is mainly produced by NK/ILC1 cells and T cells, and…”
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Paired acute‐baseline serum tryptase levels in perioperative anaphylaxis: An observational study by Vitte, Joana, Amadei, Laurent, Gouitaa, Marion, Mezouar, Soraya, Zieleskiewicz, Laurent, Albanese, Jacques, Bruder, Nicolas, Lagier, David, Mertès, Paul M., Mège, Jean‐Louis, Schwartz, Lawrence B., Leone, Marc

“…Background Anaphylaxis is recognized mainly through clinical criteria, which may lack specificity or relevance in the perioperative setting. The transient…”
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COVID-19 gender susceptibility and outcomes: A systematic review by Lakbar, Ines, Luque-Paz, David, Mege, Jean-Louis, Einav, Sharon, Leone, Marc

“…Epidemiological differences between men and women have been reported with regards to sepsis, influenza and severe coronavirus infections including SARS-CoV and…”
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Macrophage Polarization in Bacterial Infections by Benoit, Marie, Desnues, Benoit, Mege, Jean-Louis

“…Converging studies have shown that M1 and M2 macrophages are functionally polarized in response to microorganisms and host mediators. Gene expression profiling…”
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Monocytes and Macrophages, Targets of Severe Acute Respiratory Syndrome Coronavirus 2: The Clue for Coronavirus Disease 2019 Immunoparalysis by Boumaza, Asma, Gay, Laetitia, Mezouar, Soraya, Bestion, Eloïne, Diallo, Aïssatou Bailo, Michel, Moise, Desnues, Benoit, Raoult, Didier, La Scola, Bernard, Halfon, Philippe, Vitte, Joana, Olive, Daniel, Mege, Jean-Louis

“…Abstract Background Coronavirus disease 2019 (COVID-19) clinical expression is pleiomorphic, severity is related to age and comorbidities such as diabetes and…”
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Sexual Dimorphism and Gender in Infectious Diseases by Gay, Laetitia, Melenotte, Cléa, Lakbar, Ines, Mezouar, Soraya, Devaux, Christian, Raoult, Didier, Bendiane, Marc-Karim, Leone, Marc, Mège, Jean-Louis

“…Epidemiological studies and clinical observations show evidence of sexual dimorphism in infectious diseases. Women are at less risk than men when it comes to…”
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Macrophage polarization and bacterial infections by Mège, Jean-Louis, Mehraj, Vikram, Capo, Christian

“…PURPOSE OF REVIEWMacrophages are the first line of defense against pathogens, and the mode of their activation will determine the success or failure of the…”
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A Granulocytic Signature Identifies COVID-19 and Its Severity by Vitte, Joana, Diallo, Aïssatou Bailo, Boumaza, Asma, Lopez, Alexandre, Michel, Moïse, Allardet-Servent, Jérôme, Mezouar, Soraya, Sereme, Youssouf, Busnel, Jean-Marc, Miloud, Tewfik, Malergue, Fabrice, Morange, Pierre-Emmanuel, Halfon, Philippe, Olive, Daniel, Leone, Marc, Mege, Jean-Louis

“…Abstract Background An unbiased approach to SARS-CoV-2–induced immune dysregulation has not been undertaken so far. We aimed to identify previously unreported…”
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The E-Cadherin Cleavage Associated to Pathogenic Bacteria Infections Can Favor Bacterial Invasion and Transmigration, Dysregulation of the Immune Response and Cancer Induction in Humans by Devaux, Christian A., Mezouar, Soraya, Mege, Jean-Louis

“…Once bound to the epithelium, pathogenic bacteria have to cross epithelial barriers to invade their human host. In order to achieve this goal, they have to…”
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Role of Vγ9vδ2 T lymphocytes in infectious diseases by Gay, Laetitia, Mezouar, Soraya, Cano, Carla, Frohna, Paul, Madakamutil, Loui, Mège, Jean-Louis, Olive, Daniel

“…The T cell receptor Vγ9Vδ2 T cells bridge innate and adaptive antimicrobial immunity in primates. These Vγ9Vδ2 T cells respond to phosphoantigens (pAgs)…”
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Evaluating ELISA, Immunofluorescence, and Lateral Flow Assay for SARS-CoV-2 Serologic Assays by Michel, Moïse, Bouam, Amar, Edouard, Sophie, Fenollar, Florence, Di Pinto, Fabrizio, Mège, Jean-Louis, Drancourt, Michel, Vitte, Joana

“…The SARS-CoV-2 outbreak has emerged at the end of 2019. Aside from the detection of viral genome with specific RT-PCR, there is a growing need for reliable…”
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Expression of ACE2, Soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin-(1-7) Is Modulated in COVID-19 Patients by Osman, Ikram Omar, Melenotte, Cléa, Brouqui, Philippe, Million, Matthieu, Lagier, Jean-Christophe, Parola, Philippe, Stein, Andréas, La Scola, Bernard, Meddeb, Line, Mege, Jean-Louis, Raoult, Didier, Devaux, Christian A

“…The etiological agent of COVID-19 SARS-CoV-2, is primarily a pulmonary-tropic coronavirus. Infection of alveolar pneumocytes by SARS-CoV-2 requires virus…”
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Modulation of the E-cadherin in human cells infected in vitro with Coxiella burnetii by Omar Osman, Ikram, Mezouar, Soraya, Brahim-Belhaouari, Djamal, Mege, Jean-Louis, Devaux, Christian Albert

“…High concentration of soluble E-cadherin (E-cad) was previously found in sera from Q fever patients. Here, BeWo cells which express a high concentration of…”
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Gut microbiota in systemic lupus erythematosus patients and lupus mouse model: a cross species comparative analysis for biomarker discovery by Toumi, Eya, Goutorbe, Benoit, Plauzolles, Anne, Bonnet, Marion, Mezouar, Soraya, Militello, Muriel, Mege, Jean-Louis, Chiche, Laurent, Halfon, Philippe

“…An increasing number of studies have provided strong evidence that gut microbiota interact with the immune system and stimulate various mechanisms involved in…”
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Anti-Jo-1 autoantibodies: biomarkers of severity and evolution of the disease in antisynthetase syndrome by Arcani, Robin, Rey, Louise, Mazziotto, Alice, Bertin, Daniel, Kaplanski, Gilles, Jarrot, Pierre-André, Lafforgue, Pierre, Venton, Geoffroy, Heim, Xavier, Villani, Patrick, Mège, Jean-Louis, Brodovitch, Alexandre, Bardin, Nathalie

“…Anti-Jo-1 autoantibodies represent essential markers in the diagnosis of antisynthetase syndrome (ASS). In this retrospective study, we aimed to investigate…”
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Tumor Necrosis Factor Inhibitors Exacerbate Whipple’s Disease by Reprogramming Macrophage and Inducing Apoptosis by Boumaza, Asma, Mezouar, Soraya, Bardou, Matthieu, Raoult, Didier, Mège, Jean-Louis, Desnues, Benoit

“…Tropheryma whipplei is the agent of Whipple’s disease, a rare systemic disease characterized by macrophage infiltration of the intestinal mucosa. The disease…”
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Female hormones prevent sepsis-induced cardiac dysfunction: an experimental randomized study by Xerri, Alexandre, Gallardo, Frédéric, Kober, Frank, Mathieu, Calypso, Fourny, Natacha, Tran, Thi Thom, Mege, Jean-Louis, Singer, Mervyn, Lalevée, Nathalie, Bernard, Monique, Leone, Marc

“…Although epidemiologic research has demonstrated significant differences in incidence and outcomes of sepsis according to sex, their underlying biological…”
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Tumor Necrosis Factor-Alpha Antagonist Interferes With the Formation of Granulomatous Multinucleated Giant Cells: New Insights Into Mycobacterium tuberculosis Infection by Mezouar, Soraya, Diarra, Issa, Roudier, Jean, Desnues, Benoit, Mege, Jean-Louis

“…More than half of tuberculosis cases in the world are due to resuscitation of dormant ( ) sequestered into cell-derived structures called granulomas. It is…”
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