Search Results - "Megaw, Roly"

Mechanisms of Photoreceptor Death in Retinitis Pigmentosa by Newton, Fay, Megaw, Roly

“…Retinitis pigmentosa (RP) is the most common cause of inherited blindness and is characterised by the progressive loss of retinal photoreceptors. However, RP…”
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Posner-Schlossman Syndrome by Megaw, Roly, MBChB, PhD, FRCOphth, Agarwal, Pankaj Kumar, MBChB, DO, FRCSEd, FRCOphth

“…Abstract Posner-Schlossman syndrome (PSS), or glaucomatocyclitic crisis, is a unilateral ocular condition characterized by recurrent attacks of…”
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RPGR: Its role in photoreceptor physiology, human disease, and future therapies by Megaw, Roly D., Soares, Dinesh C., Wright, Alan F.

“…Mammalian photoreceptors contain specialised connecting cilia that connect the inner (IS) to the outer segments (OS). Dysfunction of the connecting cilia due…”
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Disease mechanisms of X-linked retinitis pigmentosa due to RP2 and RPGR mutations by Lyraki, Rodanthi, Megaw, Roly, Hurd, Toby

“…Photoreceptor degeneration is the prominent characteristic of retinitis pigmentosa (RP), a heterogeneous group of inherited retinal dystrophies resulting in…”
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A Systematic Review and Meta-Analyses of Interventional Clinical Trial Studies for Gene Therapies for the Inherited Retinal Degenerations (IRDs) by Tuohy, Gearóid P, Megaw, Roly

“…IRDs are one of the leading causes of visual loss in children and young adults. Mutations in over 271 genes lead to retinal dysfunction, degeneration and sight…”
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Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models by Megaw, Roly, Abu-Arafeh, Hashem, Jungnickel, Melissa, Mellough, Carla, Gurniak, Christine, Witke, Walter, Zhang, Wei, Khanna, Hemant, Mill, Pleasantine, Dhillon, Baljean, Wright, Alan F., Lako, Majlinda, ffrench-Constant, Charles

“…Mutations in the Retinitis Pigmentosa GTPase Regulator ( RPGR ) cause X-linked RP (XLRP), an untreatable, inherited retinal dystrophy that leads to premature…”
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Lateral thinking – Interocular symmetry and asymmetry in neurovascular patterning, in health and disease by Cameron, James R., Megaw, Roly D., Tatham, Andrew J., McGrory, Sarah, MacGillivray, Thomas J., Doubal, Fergus N., Wardlaw, Joanna M., Trucco, Emanuele, Chandran, Siddharthan, Dhillon, Baljean

“…No biological system or structure is likely to be perfectly symmetrical, or have identical right and left forms. This review explores the evidence for eye and…”
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Ciliary tip actin dynamics regulate photoreceptor outer segment integrity by Megaw, Roly, Moye, Abigail, Zhang, Zhixian, Newton, Fay, McPhie, Fraser, Murphy, Laura C., McKie, Lisa, He, Feng, Jungnickel, Melissa K., von Kriegsheim, Alex, Tennant, Peter A., Brotherton, Chloe, Gurniak, Christine, Gross, Alecia K., Machesky, Laura M., Wensel, Theodore G., Mill, Pleasantine

“…As signalling organelles, cilia regulate their G protein-coupled receptor content by ectocytosis, a process requiring localised actin dynamics to alter…”
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Optimising cataract surgery in patients with age-related macular degeneration by Teh, Boon Lin, MBChB (Hons), Megaw, Roly, FRCOphth, Borooah, Shyamanga, FRCOphth, Dhillon, Baljean, FRCOphth, FRCSEd

“…Abstract Age-related macular degeneration (AMD) is one of the leading causes of visual impairment. The development of cataract in AMD patients poses challenges…”
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Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis by Hall, Emma A, Kumar, Dhivya, Prosser, Suzanna L, Yeyati, Patricia L, Herranz-Pérez, Vicente, García-Verdugo, Jose Manuel, Rose, Lorraine, McKie, Lisa, Dodd, Daniel O, Tennant, Peter A, Megaw, Roly, Murphy, Laura C, Ferreira, Marisa F, Grimes, Graeme, Williams, Lucy, Quidwai, Tooba, Pelletier, Laurence, Reiter, Jeremy F, Mill, Pleasantine

“…Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated by Pericentriolar material 1 (PCM1). To study the requirement for…”
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Use of induced pluripotent stem-cell technology to understand photoreceptor cytoskeletal dynamics in retinitis pigmentosa by Megaw, Roly, Dr, Mellough, Carla, PhD, Wright, Alan, Prof, Lako, Majlinda, Prof, ffrench-Constant, Charles, Prof

“…Abstract Background Retinitis pigmentosa, which affects one in 3000 people, causes blindness and has no treatment. Mutations in the retinitis pigmentosa GTPase…”
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Papillorenal syndrome in a family with unusual complications by Megaw, Roly D, Lampe, Anne, Dhillon, Baljean, Yoshida, Shigeo, Wright, Alan F

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Secondary pigment dispersion syndrome with single-piece acrylic IOL by Hadid, Omar, MBChB, MRCP, MRCSEd, FRCOphth, Megaw, Roly, MBChB, BScMedSci, Owen, Rona, MBChB, Fraser, Scott, MBChB, FRCS, FRCOphth, MD

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Molecular Mechanisms Governing Sight Loss in Inherited Cone Disorders by Brotherton, Chloe, Megaw, Roly

“…Inherited cone disorders (ICDs) are a heterogeneous sub-group of inherited retinal disorders (IRDs), the leading cause of sight loss in children and…”
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Automated detection of age-related macular degeneration in color fundus photography: a systematic review by Pead, Emma, Megaw, Roly, Cameron, James, Fleming, Alan, Dhillon, Baljean, Trucco, Emanuele, MacGillivray, Thomas

“…The rising prevalence of age-related eye diseases, particularly age-related macular degeneration, places an ever-increasing burden on health care providers. As…”
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Measurement of Intraocular Pressure by Patients With Glaucoma by Pronin, Savva, Brown, Lyndsay, Megaw, Roly, Tatham, Andrew J

“…The ability of patients to measure their own intraocular pressure (IOP) would allow more frequent measurements and better appreciation of peak IOP and IOP…”
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Stem Cell Therapies in the Management of Diabetic Retinopathy by Megaw, Roly, Dhillon, Bal

“…Diabetic retinopathy is the leading cause of blindness in the working population. We now understand that the pathogenesis of the disease contains both a…”
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UVR and RPE – The Good, the Bad and the degenerate Macula by Anderson, Graham, Borooah, Shyamanga, Megaw, Roly, Bagnaninchi, Pierre, Weller, Richard, McLeod, Andrew, Dhillon, Baljean

“…Ultraviolet Radiation (UVR) has a well-established causative influence within the aetiology of conditions of the skin and the anterior segment of the eye…”
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Anterior segment phenotypic changes in late-onset retinal degeneration with Ser163Arg mutation in CTRP5/C1QTNF5 by Lando, Leonardo, Nguyen, Anne Xuan-Lan, Li, Randa Tsz Ha, Megaw, Roly, Dhillon, Baljean, Borooah, Shyamanga

“…Purpose Late-onset retinal degeneration (L-ORD) is a rare retinal dystrophy with anterior segment (AS) abnormalities, including long anterior zonules (LAZ) and…”
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Response to the Letter to the Editor–Fresnel Prism Intraocular Lens and Scharioth Macula Lens by Teh, Boon Lin, Megaw, Roly, Borooah, Shyamanga, Dhillon, Baljean

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