Search Results - "Meflah, Khaled"

Distinct Domains Control the Addressing and the Insertion of Bax into Mitochondria by Cartron, Pierre-François, Arokium, Hubert, Oliver, Lisa, Meflah, Khaled, Manon, Stephen, Vallette, François M.

“…The translocation of Bax from the cytosol into the mitochondrial outer membrane is a central event during apoptosis. We report that beyond the addressing step,…”
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Nonredundant Role of Bax and Bak in Bid-Mediated Apoptosis by Cartron, Pierre-François, Juin, Philippe, Oliver, Lisa, Martin, Stéphane, Meflah, Khaled, Vallette, François M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The N-terminal End of Bax Contains a Mitochondrial-targeting Signal by Cartron, Pierre-François, Priault, Muriel, Oliver, Lisa, Meflah, Khaled, Manon, Stephen, Vallette, François M

“…The translocation of Bax α, a pro-apoptotic member of the BCL-2 family from the cytosol to mitochondria, is a central event of the apoptotic program. We…”
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Minimal BH3 Peptides Promote Cell Death by Antagonizing Anti-apoptotic Proteins by Moreau, Carole, Cartron, Pierre-François, Hunt, Abigail, Meflah, Khaled, Green, Douglas R., Evan, Gerard, Vallette, François M., Juin, Philippe

“…The pro-apoptotic “BH3 domain-only” proteins of the Bcl-2 family (e.g. Bid and Bad) transduce multiple death signals to the mitochondrion. They interact with…”
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The Mitochondrial Apoptosis-induced Channel (MAC) Corresponds to a Late Apoptotic Event by Guihard, Gilles, Bellot, Gregory, Moreau, Carole, Pradal, Gilbert, Ferry, Nicolas, Thomy, Raphael, Fichet, Paulette, Meflah, Khaled, Vallette, François Marie

“…We have investigated the mechanism responsible for mitochondria permeabilization occurring during cell apoptosis. We have developed an in vivo model of…”
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The p18 Truncated Form of Bax Behaves Like a Bcl-2 Homology Domain 3-only Protein by Cartron, Pierre-François, Oliver, Lisa, Juin, Philippe, Meflah, Khaled, Vallette, François M.

“…p21Bax is a pro-apoptotic member of the Bcl-2 family and is converted by calpain into a truncated form called p18Bax. This proteolysis enhanced the apoptogenic…”
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Profiling dendritic cell maturation with dedicated microarrays by McIlroy, Dorian, Tanguy-Royer, Séverine, Le Meur, Nolwenn, Guisle, Isabelle, Royer, Pierre-Joseph, Léger, Jean, Meflah, Khaled, Grégoire, Marc

“…Dendritic cell (DC) maturation is the process by which immature DC in the periphery differentiate into fully competent antigen‐presenting cells that initiate…”
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Induction of a Caspase-3-like Activity by Calcium in Normal Cytosolic Extracts Triggers Nuclear Apoptosis in a Cell-free System by Juin, P, Pelletier, M, Oliver, L, Tremblais, K, Grégoire, M, Meflah, K, Vallette, F M

“…Calcium is involved in several steps of the apoptotic process. In nuclei, endonucleases are presumed to be the main targets of calcium; however, little is…”
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Immunomodulatory effects of tumor‐associated fibroblasts in colorectal‐tumor development by Lieubeau, Blandine, Heymann, Marie‐Françoise, Henry, Frédéric, Barbieux, Isabelle, Meflah, Khaled, Grégoire, Marc

“…In order to elucidate the role of myofibroblasts in tumor development, we compared fibroblastic reactions and their implications in the immune response in…”
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Changes in liver mitochondrial plasticity induced by brain tumor by Pouliquen, Daniel, Olivier, Christophe, Debien, Emilie, Meflah, Khaled, Vallette, François M, Menanteau, Jean

“…Accumulating data suggest that liver is a major target organ of systemic effects observed in the presence of a cancer. In this study, we investigated the…”
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The role of transforming growth factor β1 in the fibroblastic reaction associated with rat colorectal tumor development by LIEUBEAU, B, GARRIGUE, L, BARBIEUX, I, KHALED MEFLAH, GREGOIRE, M

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Impact of proapoptotic proteins Bax and Bak in tumor progression and response to treatment by Cartron, Pierre-François, Juin, Philippe, Oliver, Lisa, Meflah, Khaled, Vallette, François M

“…The cell death program, apoptosis, is currently viewed as the ultimate obstacle in cancer therapy. Inhibition of apoptosis is thought to be involved in both…”
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Role for α1,2‐fucosyltransferase and histo‐blood group antigen H type 2 in resistance of rat colon carcinoma cells to 5‐fluorouracil by Cordel, Sandrine, Goupille, Caroline, Hallouin, Florence, Meflah, Khaled, Le Pendu, Jacques

“…5‐Fluorouracil (5‐FU) is a drug of standard use in chemotherapy of colon carcinoma. However, its efficacy is limited by inherent and acquired cell resistance…”
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Opposite role of Bax and BCL-2 in the anti-tumoral responses of the immune system by Bougras, Gwenola, Cartron, Pierre-François, Gautier, Fabien, Martin, Stéphane, LeCabellec, Marité, Meflah, Khaled, Gregoire, Marc, Vallette, François M

“…The relative role of anti apoptotic (i.e. Bcl-2) or pro-apoptotic (e.g. Bax) proteins in tumor progression is still not completely understood. The rat glioma…”
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An interleukin 2/sodium butyrate combination as immunotherapy for rat colon cancer peritoneal carcinomatosis by Perrin, P, Cassagnau, E, Burg, C, Patry, Y, Vavasseur, F, Harb, J, Le Pendu, J, Douillard, J Y, Galmiche, J P, Bornet, F

“…Immunotherapy using interleukin 2 has had disappointing results in the treatment of colon cancer. Overcoming escape mechanisms, such as lack of antigen…”
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Over‐expression of a novel member of the immunoglobulin superfamily in Min mouse intestinal adenomas by Chadéneau, Corinne, LeCabellec, Marité, LeMoullac, Béatrice, Meflah, Khaled, Denis, Marc G.

“…Germline mutations of the APC (adenomatous polyposis coli) gene lead to multiple intestinal tumors in familial adenomatous polyposis patients and in Min…”
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The First α Helix of Bax Plays a Necessary Role in Its Ligand-Induced Activation by the BH3-Only Proteins Bid and PUMA by Cartron, Pierre-François, Gallenne, Tristan, Bougras, Gwenola, Gautier, Fabien, Manero, Florence, Vusio, Patricia, Meflah, Khaled, Vallette, François M., Juin, Philippe

“…The mechanism by which some BH3-only proteins of the Bcl-2 family directly activate the “multidomain” proapoptotic member Bax is poorly characterized. We…”
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5‐fluorouracil‐resistant colonic tumors are highly responsive to sodium butyrate/interleukin‐2 bitherapy in rats by Cordel, Sandrine, Heymann, Marie‐Françoise, Boisteau, Olivier, Oliver, Lisa, Le Pendu, Jacques, Grégoire, Marc, Meflah, Khaled

“…Advanced colorectal cancer is generally refractory to 5‐fluorouracil (5‐FU) chemotherapy. This is linked to the emergence of resistant cell populations,…”
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Immunization against a rat colon carcinoma by sodium butyrate-treated cells but not by interleukin 2-secreting cells by Patry, Y, Douillard, J Y, Meflah, K, Le Pendu, J

“…Vaccination of patients with colon cancer with irradiated autologous tumor cells and bacille Calmette-Guérin (BCG) was reported to augment mean survival. It…”
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Enhancement of Gut Immune Functions by Short-Chain Fructooligosaccharides and Reduction of Colon Cancer Risk by BORNET, Francis R. J., MEFLAH, Khaled, MENANTEAU, Jean

“…Short-chain fructooligosaccharides occur in a number of edible plants, such as chicory, onions, asparagus, wheat, etc. They are produced industrially from…”
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