Search Results - "Meetei, Potshangbam Angamba"
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RAPD, ISSR, and SCoT markers based genetic stability assessment of micropropagated Dendrobium fimbriatum Lindl. var. oculatum Hk. f.- an important endangered orchid
Published in Physiology and molecular biology of plants (01-02-2021)“…Dendrobium fimbriatum is an ornamental and medicinal orchid listed in the Red data book of IUCN. Phytohormones’ effect on the in vitro regeneration of the…”
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Discovery of sulfone-resistant dihydropteroate synthase (DHPS) as a target enzyme for kaempferol, a natural flavanoid
Published in Heliyon (01-02-2020)“…Kaempferol is a ubiquitous flavonoid, found in various plants having a wide range of known pharmacological activities, including antioxidant, antiinflammatory,…”
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3
3D-QSAR and molecular docking studies of 2-pyrimidinecarbonitrile derivatives as inhibitors against falcipain-3
Published in Bioorganic & medicinal chemistry letters (01-12-2011)“…3D-QSAR study with CoMFA and CoMSIA methods was carried out on a series of 2-pyrimidinecarbonitrile derivatives that exhibit activity against falcipain-3. The…”
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4
Hyperoxidation of Peroxiredoxin 6 Induces Alteration from Dimeric to Oligomeric State
Published in Antioxidants (02-02-2019)“…Peroxiredoxins(Prdx), the family of non-selenium glutathione peroxidases, are important antioxidant enzymes that defend our system from the toxic reactive…”
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5
Ligand-Based Pharmacophore Modeling and Virtual Screening of RAD9 Inhibitors
Published in Journal of chemistry (01-01-2013)“…Human RAD9 is a key cell-cycle checkpoint protein that participates in DNA repair, activation of multiple cell cycle phase checkpoints, and apoptosis. Aberrant…”
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Studies on conformational changes induced by binding of pendimethalin with human serum albumin
Published in Chemosphere (Oxford) (01-03-2020)“…Pendimethalin (PND) is a widely used herbicide in modern means of agricultural practices. So, its toxic residues exist extensively in the environment and can…”
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Efficiency of RAPD, ISSR, iPBS, SCoT and phytochemical markers in the genetic relationship study of five native and economical important bamboos of North-East India
Published in Phytochemistry (Oxford) (01-06-2020)“…10 primers each of random amplified polymorphic DNA (RAPD), inter-simple sequence repeats (ISSR), inter primer binding site (iPBS) and start codon targeted…”
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CXCR4 as possible druggable target linking inflammatory bowel disease and Parkinson's disease
Published in Metabolic brain disease (01-03-2023)“…Parkinson’s disease (PD) is a chronic, progressive, and second most prevalent neurological disorder affecting the motor system. It has been found that people…”
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An in silico approach to identify potential medicinal plants for treating Alzheimer disease: a case study with acetylcholinesterase
Published in Journal of biomolecular structure & dynamics (04-03-2022)“…Alzheimer's disease (AD) is a progressive neurological disorder affecting an estimated 10 million people worldwide. There is no cure for AD, and only a handful…”
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MedPServer: A database for identification of therapeutic targets and novel leads pertaining to natural products
Published in Chemical biology & drug design (01-04-2019)“…Natural products have been the source of treatment for various human diseases from time immemorial. Interests in natural product‐based scaffolds for the…”
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Discovery of dual cation-π inhibitors of acetylcholinesterase: design, synthesis and biological evaluation
Published in Pharmacological reports (01-06-2020)“…Alzheimer's disease (AD) is a widespread dementia-related disease affecting mankind worldwide. A cholinergic hypothesis is considered the most effective target…”
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Conservation strategies for endemic Dendrocalamus manipureanus: A study on genetic diversity and population structure based on molecular and phytochemical markers
Published in South African journal of botany (01-01-2023)“…[Display omitted] •Genetic diversity studies were conducted on endemic D. manipureanus using molecular and phytochemical markers.•Population differentiation…”
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The anti-oxidant enzyme, Prdx6 might have cis-acting regulatory sequence(s)
Published in International journal of biological macromolecules (15-04-2020)“…Peroxiredoxin 6 (Prdx6) is a ubiquitously expressed 1-cysteine Peroxiredoxin found throughout all phyla. In mammals, under different physiological conditions,…”
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Med PS erver: A database for identification of therapeutic targets and novel leads pertaining to natural products
Published in Chemical biology & drug design (01-04-2019)“…Natural products have been the source of treatment for various human diseases from time immemorial. Interests in natural product‐based scaffolds for the…”
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Epoxydicoumarin Derivative is a Novel Non‐Nucleoside TLR8 Agonist: Screening, Synthesis and Biological Evaluation
Published in ChemistrySelect (Weinheim) (28-06-2021)“…Toll‐like receptors (TLRs) activate host innate immunity by recognizing microbial ligands and viral nucleic acids. Of late, TLR8 has emerged as an attractive…”
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3D-QSAR and Molecular Docking Studies on Substituted Isothiazole Analogs as Inhibitors Against MEK-1 Kinase
Published in Chemical biology & drug design (01-01-2012)“…MEK‐1 and MEK‐2 are dual‐specificity kinases and important components in the mitogen‐activated protein kinase pathway. These enzymes are crucial for normal…”
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ClosIndb: A resource for computationally derived information from clostridial genomes
Published in Infection, genetics and evolution (01-07-2015)“…•ClosIndb is a web resource which host in silico analysis of clostridium species.•It adressed features like regulatory regions, orthologs, physicochemical…”
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Modeling of babesipain-1 and identification of natural and synthetic leads for bovine babesiosis drug development
Published in Journal of molecular modeling (01-04-2016)“…Babesiosis is a tick-borne, zoonotic disease caused by species of the intraerythrocytic protozoan Babesia . It is distributed all around the world and affects…”
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In silico screening for identification of novel β-1,3-glucan synthase inhibitors using pharmacophore and 3D-QSAR methodologies
Published in SpringerPlus (04-07-2016)“…The enzyme β-1,3-glucan synthase, which catalyzes the synthesis of β-1,3-glucan, an essential and unique structural component of the fungal cell wall, has been…”
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In silico screening for identification of novel [beta]-1,3-glucan synthase inhibitors using pharmacophore and 3D-QSAR methodologies
Published in SpringerPlus (01-07-2016)“…The enzyme [beta]-1,3-glucan synthase, which catalyzes the synthesis of [beta]-1,3-glucan, an essential and unique structural component of the fungal cell…”
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