Search Results - "Meerschaert, Kimberly A."
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Kappa Opioid Receptor Distribution and Function in Primary Afferents
Published in Neuron (Cambridge, Mass.) (19-09-2018)“…Primary afferents are known to be inhibited by kappa opioid receptor (KOR) signaling. However, the specific types of somatosensory neurons that express KOR…”
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A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut
Published in Science (American Association for the Advancement of Science) (02-08-2024)“…Neuroimmune cross-talk participates in intestinal tissue homeostasis and host defense. However, the matrix of interactions between arrays of molecularly…”
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Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection
Published in Cell (27-10-2022)“…Neuroepithelial crosstalk is critical for gut physiology. However, the mechanisms by which sensory neurons communicate with epithelial cells to mediate gut…”
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Unique Molecular Characteristics of Visceral Afferents Arising from Different Levels of the Neuraxis: Location of Afferent Somata Predicts Function and Stimulus Detection Modalities
Published in The Journal of neuroscience (16-09-2020)“…Viscera receive innervation from sensory ganglia located adjacent to multiple levels of the brainstem and spinal cord. Here we examined whether molecular…”
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New Insights on Extrinsic Innervation of the Enteric Nervous System and Non-neuronal Cell Types That Influence Colon Function
Published in Advances in experimental medicine and biology (01-01-2022)“…The enteric nervous system not only innervates the colon to execute various functions in a semi-autonomous manner but also receives neural input from three…”
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Sympathetic Input to Multiple Cell Types in Mouse and Human Colon Produces Region-Specific Responses
Published in Gastroenterology (New York, N.Y. 1943) (01-03-2021)“…The colon is innervated by intrinsic and extrinsic neurons that coordinate functions necessary for digestive health. Sympathetic input suppresses colon…”
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Neuronally expressed PDL1, not PD1, suppresses acute nociception
Published in Brain, behavior, and immunity (01-11-2022)“…•PDL1, but not PD1, is widely expressed in murine and human sensory neurons.•PD1 inhibits capsaicin-evoked behaviors and Ca2+ via reduction of membrane…”
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A chemogenetic screen for neuroimmune interplay reveals Trpv1+ neuron control of Tregs in gut
Published in Science (American Association for the Advancement of Science) (02-08-2024)“…Neuroimmune crosstalk participates in intestinal tissue homeostasis and host defense. However, the matrix of interactions between arrays of molecularly-defined…”
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Journal Article -
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The Role of Primary Afferents from Different Levels of the Neuraxis in Colon Function
Published 01-01-2021“…Visceral organs receive sensory innervation from primary afferents arising from multiple levels of the neuroaxis. The reason for these different levels of…”
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Dissertation