Ionizing radiation enhances IL-6 and IL-8 production by human endothelial cells

Irradiation exposure is known to induce an inflammatory reaction. Endothelial cells play a crucial role both in the inflammatory process and in radiation damage. Therefore, supernatants and cell lysates of ^(60)Co-irradiated human umbilical vein endothelial cells (HUVEC) have been assessed for the p...

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Bibliographic Details
Published in:	Mediators of Inflammation Vol. 1997; no. 3; pp. 185 - 193
Main Authors:	Meeren, A V, Bertho, J M, Vandamme, M, Gaugler, M H
Format:	Journal Article
Language:	English
Published:	United States Hindawi Limiteds 1997 Hindawi Publishing Corporation Hindawi Limited
Subjects:	Cytokines Inflamatory response Endothelial cells γ Irradiation
Online Access:	Get full text
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Summary:	Irradiation exposure is known to induce an inflammatory reaction. Endothelial cells play a crucial role both in the inflammatory process and in radiation damage. Therefore, supernatants and cell lysates of ^(60)Co-irradiated human umbilical vein endothelial cells (HUVEC) have been assessed for the presence of pro-inflammatory cytokines. After γ irradiation, interleukin (IL)-1α, IL-1β and tumor necrosis factor (TNF)-α remained undetectable in both cell supernatants and cell lysates. However, a dose-dependent increase in the production of IL-6 and IL-8 has been demonstrated up to 6 days after exposure. These data indicate that the pro-inflammatory cytokines IL-6 and IL-8 may be involved in the inflammatory response of vascular endothelium induced by exposure to ionizing radiation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0962-9351 1466-1861
DOI:	10.1080/09629359791677