Search Results - "Meeks, Joshua J."

Treatment of Non-Metastatic Muscle-Invasive Bladder Cancer: AUA/ASCO/ASTRO/SUO Guideline by Chang, Sam S, Bochner, Bernard H, Chou, Roger, Dreicer, Robert, Kamat, Ashish M, Lerner, Seth P, Lotan, Yair, Meeks, Joshua J, Michalski, Jeff M, Morgan, Todd M, Quale, Diane Z, Rosenberg, Jonathan E, Zietman, Anthony L, Holzbeierlein, Jeffrey M

“…Purpose This multidisciplinary, evidence-based guideline for clinically non-metastatic muscle-invasive bladder cancer focuses on the evaluation, treatment and…”
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Diagnosis and Treatment of Early Stage Testicular Cancer: AUA Guideline by Stephenson, Andrew, Eggener, Scott E, Bass, Eric B, Chelnick, David M, Daneshmand, Siamak, Feldman, Darren, Gilligan, Timothy, Karam, Jose A, Leibovich, Bradley, Liauw, Stanley L, Masterson, Timothy A, Meeks, Joshua J, Pierorazio, Phillip M, Sharma, Ritu, Sheinfeld, Joel

“…Testis cancer is the most common solid malignancy in young males. The purpose of this guideline is to provide a useful reference on the effective…”
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Circulating microRNA signature for the diagnosis of very high-risk prostate cancer by Alhasan, Ali H., Scott, Alexander W., Wu, Jia J., Feng, Gang, Meeks, Joshua J., Thaxton, C. Shad, Mirkin, Chad A.

“…We report the identification of a molecular signature using the Scano-miR profiling platform based on the differential expression of circulating microRNAs…”
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Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies by Zhai, Lijie, Bell, April, Ladomersky, Erik, Lauing, Kristen L, Bollu, Lakshmi, Sosman, Jeffrey A, Zhang, Bin, Wu, Jennifer D, Miller, Stephen D, Meeks, Joshua J, Lukas, Rimas V, Wyatt, Eugene, Doglio, Lynn, Schiltz, Gary E, McCusker, Robert H, Wainwright, Derek A

“…Indoleamine 2, 3-dioxygenase 1 (IDO; IDO1; INDO) is a rate-limiting enzyme that metabolizes the essential amino acid, tryptophan, into downstream kynurenines…”
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Genomic heterogeneity in bladder cancer: challenges and possible solutions to improve outcomes by Meeks, Joshua J., Al-Ahmadie, Hikmat, Faltas, Bishoy M., Taylor, John A., Flaig, Thomas W., DeGraff, David J., Christensen, Emil, Woolbright, Benjamin L., McConkey, David J., Dyrskjøt, Lars

“…Histological and molecular analyses of urothelial carcinoma often reveal intratumoural and intertumoural heterogeneity at the genomic, transcriptional and…”
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Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy by Wang, Lu, Zhao, Zibo, Ozark, Patrick A., Fantini, Damiano, Marshall, Stacy A., Rendleman, Emily J., Cozzolino, Kira A., Louis, Nundia, He, Xingyao, Morgan, Marc A., Takahashi, Yoh-hei, Collings, Clayton K., Smith, Edwin R., Ntziachristos, Panagiotis, Savas, Jeffrey N., Zou, Lihua, Hashizume, Rintaro, Meeks, Joshua J., Shilatifard, Ali

“…The lysine methyltransferase KMT2C (also known as MLL3), a subunit of the COMPASS complex, implements monomethylation of Lys4 on histone H3 (H3K4) at gene…”
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Identification of Differential Tumor Subtypes of T1 Bladder Cancer by Robertson, A. Gordon, Groeneveld, Clarice S., Jordan, Brian, Lin, Xiquo, McLaughlin, Kimberly A., Das, Arighno, Fall, Leigh Ann, Fantini, Damiano, Taxter, Timothy J., Mogil, Lauren S., Lindskrog, Sia Viborg, Dyrskjøt, Lars, McConkey, David J., Svatek, Robert S., de Reyniès, Aurélien, Castro, Mauro A.A., Meeks, Joshua J.

“…Stage T1 bladder cancers have the highest progression and recurrence rates of all non–muscle-invasive bladder cancers (NMIBCs). Most T1 cancers are treated…”
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The emerging role of homologous recombination repair and PARP inhibitors in genitourinary malignancies by Rimar, Kalen J., Tran, Phuoc T., Matulewicz, Richard S., Hussain, Maha, Meeks, Joshua J.

“…As cells age and are exposed to genotoxic stress, preservation of the genomic code requires multiple DNA repair pathways to remove single‐strand or…”
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The effect of minimally invasive prostatectomy on practice patterns of American urologists by Oberlin, Daniel T., M.D, Flum, Andrew S., M.D, Lai, Jeremy D., B.A, Meeks, Joshua J., M.D., Ph.D

“…Abstract Introduction and objectives To determine how robotic prostatectomy affects practice patterns of urologists, we examined the case volume…”
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Emerging therapeutic targets in bladder cancer by Carneiro, Benedito A, Meeks, Joshua J, Kuzel, Timothy M, Scaranti, Mariana, Abdulkadir, Sarki A, Giles, Francis J

“…Highlights • Inhibition of signaling and immunotherapy are emerging treatments for bladder cancer. • FGFR mutations/translocations are promising biomarkers for…”
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Scanometric MicroRNA Array Profiling of Prostate Cancer Markers Using Spherical Nucleic Acid–Gold Nanoparticle Conjugates by Alhasan, Ali H, Kim, Dae Y, Daniel, Weston L, Watson, Erin, Meeks, Joshua J, Thaxton, C. Shad, Mirkin, Chad A

“…We report the development of a novel Scanometric MicroRNA (Scano-miR) platform for the detection of relatively low abundance miRNAs with high specificity and…”
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Subtype-associated epigenomic landscape and 3D genome structure in bladder cancer by Iyyanki, Tejaswi, Zhang, Baozhen, Wang, Qixuan, Hou, Ye, Jin, Qiushi, Xu, Jie, Yang, Hongbo, Liu, Tingting, Wang, Xiaotao, Song, Fan, Luan, Yu, Yamashita, Hironobu, Chien, Ruby, Lyu, Huijue, Zhang, Lijun, Wang, Lu, Warrick, Joshua, Raman, Jay D, Meeks, Joshua J, DeGraff, David J, Yue, Feng

“…Muscle-invasive bladder cancers are characterized by their distinct expression of luminal and basal genes, which could be used to predict key clinical features…”
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Expression-based subtypes define pathologic response to neoadjuvant immune-checkpoint inhibitors in muscle-invasive bladder cancer by Robertson, A. Gordon, Meghani, Khyati, Cooley, Lauren Folgosa, McLaughlin, Kimberly A., Fall, Leigh Ann, Yu, Yanni, Castro, Mauro A. A., Groeneveld, Clarice S., de Reyniès, Aurélien, Nazarov, Vadim I., Tsvetkov, Vasily O., Choy, Bonnie, Raggi, Daniele, Marandino, Laura, Montorsi, Francesco, Powles, Thomas, Necchi, Andrea, Meeks, Joshua J.

“…Checkpoint immunotherapy (CPI) has increased survival for some patients with advanced-stage bladder cancer (BCa). However, most patients do not respond. Here,…”
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Incidence and outcomes of ductal carcinoma of the prostate in the USA: analysis of data from the Surveillance, Epidemiology, and End Results program by Meeks, Joshua J., Zhao, Lee C., Cashy, John, Kundu, Shilajit

“…Study Type – Prognosis (individual cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Ductal prostate cancer is a rare…”
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Genomic characterization of high-risk non-muscle invasive bladder cancer by Meeks, Joshua J, Carneiro, Benedito A, Pai, Sachin G, Oberlin, Daniel T, Rademaker, Alfred, Fedorchak, Kyle, Balasubramanian, Sohail, Elvin, Julia, Beaubier, Nike, Giles, Francis J

“…The genetic mechanisms associated with progression of high-risk non-muscle-invasive bladder cancer (HR-NMIBC) have not been described. We conducted selective…”
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Spatial comparison of molecular features associated with resistance to pembrolizumab in BCG unresponsive bladder cancer by Meghani, Khyati, Frydenlund, Noah, Yu, Yanni, Choy, Bonnie, Meeks, Joshua J

“…Intravenous immune checkpoint inhibition achieves a 40% 3-month response in BCG-unresponsive non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ…”
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Diagnostic Value of Guided Biopsies: Fusion and Cognitive-registration Magnetic Resonance Imaging Versus Conventional Ultrasound Biopsy of the Prostate by Oberlin, Daniel T, Casalino, David D, Miller, Frank H, Matulewicz, Richard S, Perry, Kent T, Nadler, Robert B, Kundu, Shilajit, Catalona, William J, Meeks, Joshua J

“…Objective To better assess the increased utilization of multiparametric magnetic resonance imaging (mpMRI) and fusion biopsy of the prostate, we compared…”
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Discrepancies in staging, treatment, and delays to treatment may explain disparities in bladder cancer outcomes: An update from the National Cancer Data Base (2004–2013) by Weiner, Adam B., Keeter, Mary-Kate, Manjunath, Adarsh, Meeks, Joshua J.

“…We sought to characterize national disparities in the diagnosis of advanced stage bladder cancer. Among patients with advanced disease, we explored disparities…”
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Radical prostatectomy: Positive surgical margins matter by Meeks, Joshua J., M.D., Ph.D, Eastham, James A., M.D

“…Abstract Objective A positive surgical margin (PSM) in the radical prostatectomy (RP) specimen is associated with biochemical recurrence (BCR) and the need for…”
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Multiple Roles for the MLL COMPASS Family in the Epigenetic Regulation of Gene Expression and in Cancer by Meeks, Joshua J, Shilatifard, Ali

“…The mixed lineage leukemia ( MLL ) gene is involved in numerous chromosomal translocations that result in acute myeloid and acute lymphoid leukemias. The MLL…”
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