Search Results - "Meek, Graham"

PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence by Xiao, Michael, Wu, Chia-Hua, Meek, Graham, Kelly, Brian, Castillo, Dara Buendia, Young, Lyndsay E A, Martire, Sara, Dhungel, Sajina, McCauley, Elizabeth, Saha, Purbita, Dube, Altair L, Gentry, Matthew S, Banaszynski, Laura A, Sun, Ramon C, Kikani, Chintan K

“…Quiescent stem cells are activated in response to a mechanical or chemical injury to their tissue niche. Activated cells rapidly generate a heterogeneous…”
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Complementary Syntheses of N,O-Protected-(S)-2-methylserine on a Multikilogram Scale by Anson, Michael S, Clark, Hugh F, Evans, Paul, Fox, Martin E, Graham, Jonathan P, Griffiths, Natalie N, Meek, Graham, Ramsden, James A, Roberts, Alastair J, Simmonds, Shaun, Walker, Matthew D, Willets, Matthew

“…Two complementary and scalable approaches have been used to manufacture multikilogram quantities of N,O-protected-(S)-2-methylserine. The first approach uses a…”
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Highly Diastereoselective Simmons−Smith Cyclopropanation of Allylic Amines by Aggarwal, Varinder K, Fang, Guang Yu, Meek, Graham

“…Cyclopropanation of allylic tertiary amines using the Simmons−Smith reagent has been achieved by employing chelating groups in close proximity to the amine…”
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An Efficient, Palladium-Catalyzed, Enantioselective Synthesis of (2R)-3-Butene-1,2-Diol and Its Use in Highly Selective Heck Reactions by Cheeseman, Natasha, Fox, Martin, Jackson, Mark, Lennon, Ian C., Meek, Graham, Trost, Barry M.

“…A robust and scalable procedure for the palladium-catalyzed dynamic kinetic asymmetric transformation of 3,4-epoxy-1-butene into (2R)-3-butene-1,2-diol with…”
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I saw the sign: the “corkscrew sign” of the hepatic arteries by Meek, Graham, Ozen, Sefa, Ozen, Merve

“…•The corkscrew sign describes the hepatic arteries' tortuous appearance in the radiologic imaging of cirrhosis patients.•The corkscrew sign is accepted as a…”
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(π-Allyl)tricarbonyliron Lactone Complexes in Organic Synthesis:  A Useful and Conceptually Unusual Route to Lactones and Lactams by Ley, Steven V, Cox, Liam R, Meek, Graham

“…The chemistry of (pi-allyl)tricarbonyliron lactone and lactam complexes and their application to organic synthesis are discussed. (pi-allyl)tricarbonyliron…”
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A highly regioselective hydroformylation of an α-chiral olefin to produce a versatile trifunctionalised orthogonally protected C5 synthon by Cobley, Christopher, Meek, Graham, Rand, Cynthia

“…A highly regioselective hydroformylation of (R)-N-phthalimido-vinylglycinol and the synthetic utility of the product is described. This paper describes a…”
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A complementary method to obtain N-acyl enamides using the Heck reaction: extending the substrate scope for asymmetric hydrogenation by Harrison, Paul, Meek, Graham

“…A series of N-acyl enamides were prepared using the Heck reaction. Asymmetric hydrogenation provided protected amines in up to 99% ee. A method to prepare…”
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Large-Scale Synthesis of a Substituted d-Phenylalanine Using Asymmetric Hydrogenation by Fox, Martin E, Jackson, Mark, Meek, Graham, Willets, Matthew

“…A synthetic route to an N-BOC d-phenylalanine pharmaceutical intermediate suitable for rapid scale-up to 150-kg scale was required. A seven-step route based on…”
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Approaches to the quaternary stereocentre and to the heterocyclic core in diazonamide A using the Heck reaction and related coupling reactions by Booker, James E M, Boto, Alicia, Churchill, Gwydion H, Green, Clive P, Ling, Matthew, Meek, Graham, Prabhakaran, Jaya, Sinclair, David, Blake, Alexander J, Pattenden, Gerald

“…In model studies towards the quaternary centre at the heart of diazonamide A (early structure 2; revised structure 1), cyclisations of the alkene-substituted…”
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Tandem Formation and [2,3] Rearrangement of Methylene Ammonium Ylides Derived from Amines and the Simmons−Smith Reagent by Aggarwal, Varinder K, Fang, Guang yu, Charmant, Jonathan P. H, Meek, Graham

“…Zinc-complexed methylene ammonium ylides are formed from tertiary amines and the Simmons−Smith reagent. These stable entities can be activated with n-BuLi to…”
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A novel synthesis of 5-hydroxy-2,2-dimethyl-10-propyl-2H-pyrano[2,3-f]chromen-8-one by Fox, Martin E., Lennon, Ian C., Meek, Graham

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Industrially Viable Syntheses of Highly Enantiomerically Enriched 1-Aryl Alcohols via Asymmetric Hydrogenation by Chaplin, David, Harrison, Paul, Henschke, Julian P, Lennon, Ian C, Meek, Graham, Moran, Paul, Pilkington, Christopher J, Ramsden, James A, Watkins, Simon, Zanotti-Gerosa, Antonio

“…The practicalities of the asymmetric hydrogenation of acetophenone derivatives are addressed. The catalysts used, derived from the precatalysts…”
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A novel synthesis of 5-hydroxy-2,2-dimethyl-10-propyl-2 H-pyrano[2,3- f]chromen-8-one by Fox, Martin E., Lennon, Ian C., Meek, Graham

“…A concise synthesis of 5-hydroxy-2,2-dimethyl-10-propyl-2 H-pyrano[2,3- f]chromen-8-one utilising a novel selective desulfonylation protocol is described. This…”
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A synthetic approach towards the aromatic macrocyclic core of diazonamide A based on sp2-sp2 coupling protocols by Boto, Alicia, Ling, Matthew, Meek, Graham, Pattenden, Gerald

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A synthetic approach towards the aromatic macrocyclic core of diazonamide A based on sp 2-sp 2 coupling protocols by Boto, Alicia, Ling, Matthew, Meek, Graham, Pattenden, Gerald

“…The scope for a range of sp 2-sp 2 coupling protocols to elaborate the phenyl-indole, indole-oxazole, oxazole-oxazole, and quaternary carbon units in the…”
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