Search Results - "Meek, D"

Mechanistic enzymology in drug discovery: a fresh perspective by Holdgate, Geoffrey A., Meek, Thomas D., Grimley, Rachel L.

“…Key Points The application of detailed mechanistic enzyme kinetics is vital for the characterization of enzyme targets; furthermore, it is crucial to aid in…”
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Characterization of adenine phosphoribosyltransferase (APRT) activity in Trypanosoma brucei brucei: Only one of the two isoforms is kinetically active by Glockzin, Kayla, Meek, Thomas D, Katzfuss, Ardala

“…Human African Trypanosomiasis (HAT), also known as sleeping sickness, is a Neglected Tropical Disease endemic to 36 African countries, with approximately 70…”
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Bone grafting, orthopaedic biomaterials, and the clinical need for bone engineering by Brydone, A S, Meek, D, Maclaine, S

“…As the population ages, the number of operations performed on bone is expected to increase. Diseases such as arthritis, tumours, and trauma can lead to defects…”
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Recommended guiding principles for reporting on camera trapping research by Meek, P. D, Ballard, G, Claridge, A, Kays, R, Moseby, K, O’Brien, T, O’Connell, A, Sanderson, J, Swann, D. E, Tobler, M, Townsend, S

“…Camera traps are used by scientists and natural resource managers to acquire ecological data, and the rapidly increasing camera trapping literature highlights…”
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Osteogenic and bactericidal surfaces from hydrothermal titania nanowires on titanium substrates by Tsimbouri, P. M., Fisher, L., Holloway, N., Sjostrom, T., Nobbs, A. H., Meek, R. M. D, Su, B., Dalby, M. J.

“…Nanotopographical cues on Ti have been shown to elicit different cell responses such as cell differentiation and selective growth. Bone remodelling is a…”
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Camera traps can be heard and seen by animals by Meek, Paul D, Ballard, Guy-Anthony, Fleming, Peter J S, Schaefer, Michael, Williams, Warwick, Falzon, Greg

“…Camera traps are electrical instruments that emit sounds and light. In recent decades they have become a tool of choice in wildlife research and monitoring…”
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Small extracellular vesicles derived from synovial fibroblasts contain distinct miRNA profiles and contribute to chondrocyte damage in osteoarthritis by Asghar, Sabha, Litherland, Gary J, Cole, John J, McInnes, Iain B, Meek, R M D, Lockhart, John C, Goodyear, Carl S, Crilly, Anne

“…Small extracellular vesicles (sEV) derived from synovial fibroblasts (SF) represent a novel molecular mechanism regulating cartilage erosion in osteoarthritis…”
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Catalytic Mechanism of Cruzain from Trypanosoma cruzi As Determined from Solvent Kinetic Isotope Effects of Steady-State and Pre-Steady-State Kinetics by Zhai, Xiang, Meek, Thomas D

“…Cruzain, an important drug target for Chagas disease, is a member of clan CA of the cysteine proteases. Understanding the catalytic mechanism of cruzain is…”
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Characterization of the PF-ILD phenotype in patients with advanced pulmonary sarcoidosis by Schimmelpennink, M. C, Meek, D. B, Vorselaars, A. D. M, Langezaal, L. C. M, van Moorsel, C. H. M, van der Vis, J. J, Veltkamp, M, Grutters, J. C

“…Abstract Background Advanced pulmonary sarcoidosis causes significant morbidity and can lead to death. Large trials demonstrated efficacy of antifibrotics in…”
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Drug-target residence time and its implications for lead optimization by Copeland, Robert A, Pompliano, David L, Meek, Thomas D

“…Much of drug discovery today is predicated on the concept of selective targeting of particular bioactive macromolecules by low-molecular-mass drugs. The…”
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Predicting local tumour progression after ablation for colorectal liver metastases: CT-based radiomics of the ablation zone by Staal, F.C.R., Taghavi, M., van der Reijd, D.J., Gomez, F.M., Imani, F., Klompenhouwer, E.G., Meek, D., Roberti, S., de Boer, M., Lambregts, D.M.J., Beets-Tan, R.G.H., Maas, M.

“…To assess whether CT-based radiomics of the ablation zone (AZ) can predict local tumour progression (LTP) after thermal ablation for colorectal liver…”
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Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36 by Poulin, Myles B., Schneck, Jessica L., Matico, Rosalie E., McDevitt, Patrick J., Huddleston, Michael J., Hou, Wangfang, Johnson, Neil W., Thrall, Sara H., Meek, Thomas D., Schramm, Vern L.

“…Nuclear receptor SET domain containing protein 2 (NSD2) catalyzes the methylation of histone H3 lysine 36 (H3K36). It is a determinant in Wolf–Hirschhorn…”
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Nitrate leaching to subsurface drains as affected by drain spacing and changes in crop production system by Kladivko, E.J, Frankenberger, J.R, Jaynes, D.B, Meek, D.W, Jenkinson, B.J, Fausey, N.R

“…Subsurface drainage is a beneficial water management practice in poorly drained soils but may also contribute substantial nitrate N loads to surface waters…”
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The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage by Nicol, S M, Bray, S E, Derek Black, H, Lorimore, S A, Wright, E G, Lane, D P, Meek, D W, Coates, P J, Fuller-Pace, F V

“…The RNA helicase p68 (DDX5) is an established co-activator of the p53 tumour suppressor that itself has a pivotal role in orchestrating the cellular response…”
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Shifting brain inhibitory balance and connectivity of the prefrontal cortex of adults with autism spectrum disorder by Ajram, L A, Horder, J, Mendez, M A, Galanopoulos, A, Brennan, L P, Wichers, R H, Robertson, D M, Murphy, C M, Zinkstok, J, Ivin, G, Heasman, M, Meek, D, Tricklebank, M D, Barker, G J, Lythgoe, D J, Edden, R A E, Williams, S C, Murphy, D G M, McAlonan, G M

“…Currently, there are no effective pharmacologic treatments for the core symptoms of autism spectrum disorder (ASD). There is, nevertheless, potential for…”
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Incidence of acquired demyelination of the CNS in Canadian children by BANWELL, B, KENNEDY, J, SEBIRE, G, MEANEY, B, DILENGE, M.-E, LORTIE, A, WHITING, S, DOJA, A, LEVIN, S, MACDONALD, E. A, MEEK, D, WOOD, E, SADOVNICK, D, LOWRY, N, BUCKLEY, D, YIM, C, AWUKU, M, GUIMOND, C, COOPER, P, GRAND'MAISON, F, BAIRD, J. B, BHAN, V, BAR-OR, A, ARNOLD, D. L, MAGALHAES, S, WAMBERA, K, CONNOLLY, M. B, YAGER, J, MAH, J. K, SHAH, N

“…The incidence of acquired demyelination of the CNS (acquired demyelinating syndromes [ADS]) in children is unknown. It is important that physicians recognize…”
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Do lethal trap devices threaten foot-hold trap capture efficacy? by Meek, Paul D., Shorter, Kathleen, Falzon, Greg

“…Foot-hold trapping is an important tool used in pest management programs in countries such as Australia, New Zealand and in North America. Research on humane…”
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ClassifyMe : A Field-Scouting Software for the Identification of Wildlife in Camera Trap Images by Falzon, Greg, Lawson, Christopher, Cheung, Ka-Wai, Vernes, Karl, Ballard, Guy A, Fleming, Peter J S, Glen, Alistair S, Milne, Heath, Mather-Zardain, Atalya, Meek, Paul D

“…We present a software tool for the automated identification of animal species from camera trap images is intended to be used by ecologists both in the field…”
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Analysis of Osteoclastogenesis/Osteoblastogenesis on Nanotopographical Titania Surfaces by Silverwood, Robert K., Fairhurst, Paul G., Sjöström, Terje, Welsh, Findlay, Sun, Yuxin, Li, Gang, Yu, Bin, Young, Peter S., Su, Bo, Meek, Robert M. D., Dalby, Matthew J., Tsimbouri, Penelope M.

“…A focus of orthopedic research is to improve osteointegration and outcomes of joint replacement. Material surface topography has been shown to alter cell…”
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Management of chronic pain in elderly, frail patients: finding a suitable, personalized method of control by Rastogi, Rahul, Meek, Brian D

“…The elderly population is projected to make up 20% of the total United States population by the year 2030. In addition, epidemiological data suggests…”
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