Search Results - "Meei-Li Huang"

Comparative Performance of SARS-CoV-2 Detection Assays Using Seven Different Primer-Probe Sets and One Assay Kit by Nalla, Arun K, Casto, Amanda M, Huang, Meei-Li W, Perchetti, Garrett A, Sampoleo, Reigran, Shrestha, Lasata, Wei, Yulun, Zhu, Haiying, Jerome, Keith R, Greninger, Alexander L

“…Nearly 400,000 people worldwide are known to have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) beginning in December 2019…”
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Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing by Joung, Julia, Ladha, Alim, Saito, Makoto, Kim, Nam-Gyun, Woolley, Ann E, Segel, Michael, Barretto, Robert P.J, Ranu, Amardeep, Macrae, Rhiannon K, Faure, Guilhem, Ioannidi, Eleonora I, Krajeski, Rohan N, Bruneau, Robert, Huang, Meei-Li W, Yu, Xu G, Li, Jonathan Z, Walker, Bruce D, Hung, Deborah T, Greninger, Alexander L, Jerome, Keith R, Gootenberg, Jonathan S, Abudayyeh, Omar O, Zhang, Feng

“…A new method for the detection of SARS-CoV-2 combines simplified extraction of RNA with isothermal amplification and CRISPR (clustered regularly interspaced…”
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Specific allelic discrimination of N501Y and other SARS‐CoV‐2 mutations by ddPCR detects B.1.1.7 lineage in Washington State by Perchetti, Garrett A., Zhu, Haiying, Mills, Margaret G., Shrestha, Lasata, Wagner, Cassia, Bakhash, Shah Mohamed, Lin, Michelle J., Xie, Hong, Huang, Meei‐Li, Mathias, Patrick, Bedford, Trevor, Jerome, Keith R., Greninger, Alexander L., Roychoudhury, Pavitra

“…Real‐time epidemiological tracking of variants of concern (VOCs) can help limit the spread of more contagious forms of severe acute respiratory syndrome…”
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In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age by Lieberman, Nicole A P, Peddu, Vikas, Xie, Hong, Shrestha, Lasata, Huang, Meei-Li, Mears, Megan C, Cajimat, Maria N, Bente, Dennis A, Shi, Pei-Yong, Bovier, Francesca, Roychoudhury, Pavitra, Jerome, Keith R, Moscona, Anne, Porotto, Matteo, Greninger, Alexander L

“…Despite limited genomic diversity, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown a wide range of clinical manifestations in different…”
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Metagenomic Analysis Reveals Clinical SARS-CoV-2 Infection and Bacterial or Viral Superinfection and Colonization by Peddu, Vikas, Shean, Ryan C, Xie, Hong, Shrestha, Lasata, Perchetti, Garrett A, Minot, Samuel S, Roychoudhury, Pavitra, Huang, Meei-Li, Nalla, Arun, Reddy, Shriya B, Phung, Quynh, Reinhardt, Adam, Jerome, Keith R, Greninger, Alexander L

“…Abstract Background More than 2 months separated the initial description of SARS-CoV-2 and discovery of its widespread dissemination in the United States…”
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Validation of SARS-CoV-2 detection across multiple specimen types by Perchetti, Garrett A., Nalla, Arun K., Huang, Meei-Li, Zhu, Haiying, Wei, Yulun, Stensland, Larry, Loprieno, Michelle A., Jerome, Keith R., Greninger, Alexander L.

“…•Modified CDC-based assays can detect SARS-CoV-2 across a range of sample types.•SARS-CoV-2 N1 assay detection sensitivity was comparable between specimen…”
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Gene editing and elimination of latent herpes simplex virus in vivo by Aubert, Martine, Strongin, Daniel E., Roychoudhury, Pavitra, Loprieno, Michelle A., Haick, Anoria K., Klouser, Lindsay M., Stensland, Laurence, Huang, Meei-Li, Makhsous, Negar, Tait, Alexander, De Silva Feelixge, Harshana S., Galetto, Roman, Duchateau, Philippe, Greninger, Alexander L., Stone, Daniel, Jerome, Keith R.

“…We evaluate gene editing of HSV in a well-established mouse model, using adeno-associated virus (AAV)-delivered meganucleases, as a potentially curative…”
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Vaccine Prevention of Maternal Cytomegalovirus Infection by Pass, Robert F, Zhang, Changpin, Evans, Ashley, Simpson, Tina, Andrews, William, Huang, Meei-Li, Corey, Lawrence, Hill, Janie, Davis, Elizabeth, Flanigan, Cynthia, Cloud, Gretchen

“…Congenital cytomegalovirus (CMV) infection is a cause of significant neonatal morbidity. Preventing maternal infection during pregnancy is a potential strategy…”
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SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98 by Addetia, Amin, Lieberman, Nicole A P, Phung, Quynh, Hsiang, Tien-Ying, Xie, Hong, Roychoudhury, Pavitra, Shrestha, Lasata, Loprieno, Michelle A, Huang, Meei-Li, Gale, Jr, Michael, Jerome, Keith R, Greninger, Alexander L

“…RNA viruses that replicate in the cytoplasm often disrupt nucleocytoplasmic transport to preferentially translate their own transcripts and prevent host…”
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Hydroxychloroquine as Postexposure Prophylaxis to Prevent Severe Acute Respiratory Syndrome Coronavirus 2 Infection : A Randomized Trial by Barnabas, Ruanne V, Brown, Elizabeth R, Bershteyn, Anna, Stankiewicz Karita, Helen C, Johnston, Christine, Thorpe, Lorna E, Kottkamp, Angelica, Neuzil, Kathleen M, Laufer, Miriam K, Deming, Meagan, Paasche-Orlow, Michael K, Kissinger, Patricia J, Luk, Alfred, Paolino, Kristopher, Landovitz, Raphael J, Hoffman, Risa, Schaafsma, Torin T, Krows, Meighan L, Thomas, Katherine K, Morrison, Susan, Haugen, Harald S, Kidoguchi, Lara, Wener, Mark, Greninger, Alexander L, Huang, Meei-Li, Jerome, Keith R, Wald, Anna, Celum, Connie, Chu, Helen Y, Baeten, Jared M

“…Effective prevention against coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently limited…”
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Helicase–Primase Inhibitor Pritelivir for HSV-2 Infection by Wald, Anna, Corey, Lawrence, Timmler, Burkhard, Magaret, Amalia, Warren, Terri, Tyring, Stephen, Johnston, Christine, Kriesel, John, Fife, Kenneth, Galitz, Lawrence, Stoelben, Susanne, Huang, Meei-Li, Selke, Stacy, Stobernack, Hans-Peter, Ruebsamen-Schaeff, Helga, Birkmann, Alexander

“…New treatments are needed for herpes simplex virus infection. In this placebo-controlled, randomized, dose-ranging trial, pritelivir, an inhibitor of the viral…”
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Direct RT-qPCR detection of SARS-CoV-2 RNA from patient nasopharyngeal swabs without an RNA extraction step by Bruce, Emily A, Huang, Meei-Li, Perchetti, Garrett A, Tighe, Scott, Laaguiby, Pheobe, Hoffman, Jessica J, Gerrard, Diana L, Nalla, Arun K, Wei, Yulun, Greninger, Alexander L, Diehl, Sean A, Shirley, David J, Leonard, Debra G B, Huston, Christopher D, Kirkpatrick, Beth D, Dragon, Julie A, Crothers, Jessica W, Jerome, Keith R, Botten, Jason W

“…The ongoing COVID-19 pandemic has created an unprecedented need for rapid diagnostic testing. The World Health Organization (WHO) recommends a standard assay…”
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Predicting infectivity: comparing four PCR‐based assays to detect culturable SARS‐CoV‐2 in clinical samples by Bruce, Emily A, Mills, Margaret G, Sampoleo, Reigran, Perchetti, Garrett A, Huang, Meei‐Li, Despres, Hannah W, Schmidt, Madaline M, Roychoudhury, Pavitra, Shirley, David J, Jerome, Keith R, Greninger, Alexander L, Botten, Jason W

“…With the COVID‐19 pandemic caused by SARS‐CoV‐2 now in its second year, there remains an urgent need for diagnostic testing that can identify infected…”
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Viral Resistance Analyses From the Remdesivir Phase 3 Adaptive COVID-19 Treatment Trial-1 (ACTT-1) by Hedskog, Charlotte, Rodriguez, Lauren, Roychoudhury, Pavitra, Huang, Meei-Li, Jerome, Keith R, Hao, Linhui, Ireton, Renee C, Li, Jiani, Perry, Jason K, Han, Dong, Camus, Gregory, Greninger, Alexander L, Gale, Michael, Porter, Danielle P

“…Abstract Background Remdesivir is approved for treatment of coronavirus disease 2019 (COVID-19) in nonhospitalized and hospitalized adult and pediatric…”
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The impact of B‐cell‐directed therapy on SARS‐CoV‐2 vaccine efficacy in chronic lymphocytic leukaemia by Ujjani, Chaitra, Shadman, Mazyar, Lynch, Ryan C., Tu, Brian, Stevenson, Philip A., Grainger, Caitlin, Zhu, Haiying, Hill, Joshua A., Huang, Meei‐Li, Nielsen, Leslie, Poh, Christina, Sorensen, Tyler, Gopal, Ajay K., Warren, Edus H., Till, Brian G., Lee, Sydney, Gausman, Daria, Smith, Stephen D., Gooley, Ted, Greninger, Alex

“…Prior reports evaluating SARS‐CoV‐2 vaccine efficacy in chronic lymphocytic leukaemia (CLL) used semiquantitative measurements of anti‐S to evaluate immunity;…”
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Validation and verification of the Abbott RealTime SARS-CoV-2 assay analytical and clinical performance by Degli-Angeli, Emily, Dragavon, Joan, Huang, Meei-Li, Lucic, Danijela, Cloherty, Gavin, Jerome, Keith R., Greninger, Alexander L., Coombs, Robert W.

“…•The expected 100 copies/mL LOD reported in the EUA Abbott RealTime SARS-CoV-2 assay product insert was exceeded.•All clinical samples positive for 24…”
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Identification of chromosomally integrated human herpesvirus 6 by droplet digital PCR by Sedlak, Ruth Hall, Cook, Linda, Huang, Meei-Li, Magaret, Amalia, Zerr, Danielle M, Boeckh, Michael, Jerome, Keith R

“…Human herpesvirus 6 (HHV-6) latently infects a majority of adults. In about 1% of the population HHV-6 exists in a chromosomally integrated form (ciHHV-6) that…”
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Herpes Simplex Virus Type 1 Shedding in Tears and Nasal and Oral Mucosa of Healthy Adults by Ramchandani, Meena, Kong, Marlene, Tronstein, Elizabeth, Selke, Stacy, Mikhaylova, Anna, Magaret, Amalia, Huang, Meei-Li, Johnston, Christine, Corey, Lawrence, Wald, Anna

“…BACKGROUNDHerpes simplex virus type 1 (HSV-1) is prevalent worldwide and causes mucocutaneous infections of the oral area. We aimed to define the frequency and…”
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Association Between Cytomegalovirus and Epstein-Barr Virus Viremia And Human Immunodeficiency Virus DNA Levels in the Reservoir of Kenyan Infants Receiving Antiretroviral Therapy by Slyker, Jennifer A, Guthrie, Brandon, Pankau, Mark, Tapia, Kenneth, Wamalwa, Dalton, Benki-Nugent, Sarah, Ngugi, Evelyn, Huang, Meei-Li, Njuguna, Irene, Langat, Agnes, John-Stewart, Grace, Lehman, Dara

“…Abstract Identifying determinants of human immunodeficiency virus (HIV) reservoir levels may inform novel viral eradication strategies. Cytomegalovirus (CMV)…”
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Kinetics of Double-Stranded DNA Viremia After Allogeneic Hematopoietic Cell Transplantation by Hill, Joshua A, Mayer, Bryan T, Xie, Hu, Leisenring, Wendy M, Huang, Meei-Li, Stevens-Ayers, Terry, Milano, Filippo, Delaney, Colleen, Jerome, Keith R, Zerr, Danielle M, Nichols, Garrett, Boeckh, Michael, Schiffer, Joshua T

“…Improved understanding of double-stranded DNA (dsDNA) virus kinetics after hematopoietic cell transplantation (HCT) would facilitate development of therapeutic…”
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