Search Results - "Meehan, C. F."

Intrinsic properties of mouse lumbar motoneurons revealed by intracellular recording in vivo by Meehan, C F, Sukiasyan, N, Zhang, M, Nielsen, J B, Hultborn, H

“…We have developed an in vivo model for intracellular recording in the adult anesthetized mouse using sharp microelectrode electrodes as a basis for…”
Get full text

Electrophysiological and morphological characterization of propriospinal interneurons in the thoracic spinal cord by Saywell, S A, Ford, T W, Meehan, C F, Todd, A J, Kirkwood, P A

“…Propriospinal interneurons in the thoracic spinal cord have vital roles not only in controlling respiratory and trunk muscles, but also in providing possible…”
Get full text

Fictive locomotion in the adult decerebrate and spinal mouse in vivo by Meehan, C.F., Grondahl, L., Nielsen, J.B., Hultborn, H.

“…Non‐technical summary  The isolated spinal cord contains networks capable of producing a locomotor rhythm. This can be evoked in vivo in decerebrate…”
Get full text

Intrinsic properties of lumbar motor neurones in the adult G127insTGGG superoxide dismutase‐1 mutant mouse in vivo: evidence for increased persistent inward currents by Meehan, C.F, Moldovan, M, Marklund, S.L, Graffmo, K.S, Nielsen, J.B, Hultborn, H

“…Aim: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by a preferential loss of motor neurones. Previous…”
Get full text

Increased Axon Initial Segment Length Results in Increased Na+ Currents in Spinal Motoneurones at Symptom Onset in the G127X SOD1 Mouse Model of Amyotrophic Lateral Sclerosis by Jørgensen, H.S., Jensen, D.B., Dimintiyanova, K.P., Bonnevie, V.S., Hedegaard, A., Lehnhoff, J., Moldovan, M., Grondahl, L., Meehan, C.F.

“…•In vivo electrophysiological recordings were made in symptomatic G127X SOD1 mice.•There were no deficits in repetitive firing in motoneurones in G127X…”
Get full text

The respiratory drive to thoracic motoneurones in the cat and its relation to the connections from expiratory bulbospinal neurones by Saywell, S. A., Anissimova, N. P., Ford, T. W., Meehan, C. F., Kirkwood, P. A.

“…The descending control of respiratory-related motoneurones in the thoracic spinal cord remains the subject of some debate. In this study, direct connections…”
Get full text

Shorter axon initial segments do not cause repetitive firing impairments in the adult presymptomatic G127X SOD-1 Amyotrophic Lateral Sclerosis mouse by Bonnevie, V. S., Dimintiyanova, K. P., Hedegaard, A., Lehnhoff, J., Grøndahl, L., Moldovan, M., Meehan, C. F.

“…Increases in axonal sodium currents in peripheral nerves are some of the earliest excitability changes observed in Amyotrophic Lateral Sclerosis (ALS)…”
Get full text

Intramuscular Botulinum toxin A injections induce central changes to axon initial segments and cholinergic boutons on spinal motoneurones in rats by Jensen, D. B., Klingenberg, S., Dimintiyanova, K. P., Wienecke, J., Meehan, C. F.

“…Intramuscular injections of botulinum toxin block pre-synaptic cholinergic release at neuromuscular junctions producing a temporary paralysis of affected motor…”
Get full text

Functional plasticity in the respiratory drive to thoracic motoneurons in the segment above a chronic lateral spinal cord lesion by Ford, T W, Anissimova, N P, Meehan, C F, Kirkwood, P A

“…A previous neurophysiological investigation demonstrated an increase in functional projections of expiratory bulbospinal neurons (EBSNs) in the segment above a…”
Get full text

Effect of nitric oxide on spinal evoked potentials and survival rate in rats with decompression sickness by Randsoe, T, Meehan, C F, Broholm, H, Hyldegaard, O

“…Nitric oxide (NO) releasing agents have, in experimental settings, been shown to decrease intravascular nitrogen bubble formation and to increase the survival…”
Get full text

Postactivation depression of the Ia EPSP in motoneurons is reduced in both the G127X SOD1 model of amyotrophic lateral sclerosis and in aged mice by Hedegaard, A, Lehnhoff, J, Moldovan, M, Grøndahl, L, Petersen, N C, Meehan, C F

“…Postactivation depression (PActD) of Ia afferent excitatory postsynaptic potentials (EPSPs) in spinal motoneurons results in a long-lasting depression of the…”
Get full text

Absence of synergy for monosynaptic Group I inputs between abdominal and internal intercostal motoneurons by Ford, T W, Meehan, C F, Kirkwood, P A

“…Internal intercostal and abdominal motoneurons are strongly coactivated during expiration. We investigated whether that synergy was paralleled by synergistic…”
Get full text

Fictive locomotion in the adult decerebrate and spinal mousein vivo by Meehan, CF, Grondahl, L, Nielsen, JB, Hultborn, H

“…Non-technical summary The isolated spinal cord contains networks capable of producing a locomotor rhythm. This can be evokedin vivoin decerebrate…”
Get full text

Rostrocaudal distribution of motoneurones and variation in ventral horn area within a segment of the feline thoracic spinal cord by Meehan, Claire F., Ford, Tim W., Road, Jeremy D., Donga, Revers, Saywell, Shane A., Anissimova, Natalia P., Kirkwood, Peter A.

“…Retrograde transport of horseradish peroxidase, applied to cut peripheral nerves, was used to determine the rostrocaudal distribution of motoneurones supplying…”
Get full text

Intrinsic properties of lumbar motor neurones in the adult GI27insTGGG superoxide dismutase-I mutant mouse in vivo: evidence for increased persistent inward currents by MEEHAN, C. F, MOLDOVAN, M, MARKLUND, S. L, GRAFFMO, K. S, NIELSEN, J. B, HULTBORN, H

Get full text