Search Results - "Meedt, Elisabeth"

Intestinal IgA positive plasma cells are highly sensitive indicators of alloreaction early after allogeneic transplantation and associate with both, graft- versus- host disease and relapse related mortality by Scheidler, Lucia, Hippe, Katrin, Ghimire, Sakhila, Weber, Daniela, Weber, Markus, Meedt, Elisabeth, Hoffmann, Petra, Lehn, Petra, Burkhardt, Ralph, Mamilos, Andreas, Edinger, Matthias, Wolff, Daniel, Poeck, Hendrik, Evert, Matthias, Gessner, Andre, Herr, Wolfgang, Holler, Ernst

“…Intestinal IgA is strongly involved in microbiota homeostasis. Since microbiota disruption is a major risk factor of acute GvHD, we addressed the kinetics of…”
Get full text

Downregulation of the vitamin D receptor expression during acute gastrointestinal graft versus host disease is associated with poor outcome after allogeneic stem cell transplantation by Matos, Carina, Mamilos, Andreas, Shah, Pranali N., Meedt, Elisabeth, Weber, Daniela, Ghimire, Saroj, Hiergeist, Andreas, Gessner, André, Dickinson, Anne, Dressel, Ralf, Walter, Lutz, Stark, Klaus, Heid, Iris M., Poeck, Hendrik, Edinger, Matthias, Wolff, Daniel, Herr, Wolfgang, Holler, Ernst, Kreutz, Marina, Ghimire, Sakhila

“…The vitamin D receptor (VDR) is critical in regulating intestinal homeostasis and emerging evidence demonstrates that VDR deficiency is a critical factor in…”
Get full text

Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation by Ghimire, Sakhila, Ederer, Katharina U, Meedt, Elisabeth, Weber, Daniela, Matos, Carina, Hiergeist, Andreas, Zeman, Florian, Wolff, Daniel, Edinger, Matthias, Poeck, Hendrik, Herr, Wolfgang, Gessner, André, Holler, Ernst, Bülow, Sigrid

“…The role of IL-22 in adult patients undergoing allogeneic stem cell transplantation (SCT) is of major interest since animal studies showed a protective and…”
Get full text

GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics by Ghimire, Sakhila, Weber, Daniela, Hippe, Katrin, Meedt, Elisabeth, Hoepting, Matthias, Kattner, Anna-Sophia, Hiergeist, Andreas, Gessner, André, Matos, Carina, Ghimire, Saroj, Wolff, Daniel, Edinger, Matthias, Hoffmann, Petra, Poeck, Hendrik, Herr, Wolfgang, Holler, Ernst

“…Microbiota can exert immunomodulatory effects by short-chain fatty acids (SCFA) in experimental models of graft-versus-host disease (GvHD) after allogeneic…”
Get full text

Interferon regulatory factor 4 plays a pivotal role in the development of aGVHD-associated colitis by Frueh, Jochen T, Campe, Julia, Sunaga-Franze, Daniele Yumi, Verheyden, Nikita A, Ghimire, Sakhila, Meedt, Elisabeth, Haslinger, Denise, Harenkamp, Sabine, Staudenraus, Daniel, Sauer, Sascha, Kreft, Andreas, Schubert, Ralf, Lohoff, Michael, Krueger, Andreas, Bonig, Halvard, Chiocchetti, Andreas G, Zeiser, Robert, Holler, Ernst, Ullrich, Evelyn

“…Interferon regulatory factor 4 (IRF4) is a master transcription factor that regulates T helper cell (Th) differentiation. It interacts with the Basic leucine…”
Get full text

Prolonged Suppression of Butyrate-Producing Bacteria Is Associated With Acute Gastrointestinal Graft-vs-Host Disease and Transplantation-Related Mortality After Allogeneic Stem Cell Transplantation by Meedt, Elisabeth, Hiergeist, Andreas, Gessner, André, Dettmer, Katja, Liebisch, Gerhard, Ghimire, Sakhila, Poeck, Hendrik, Edinger, Matthias, Wolff, Daniel, Herr, Wolfgang, Holler, Ernst, Weber, Daniela

“…Abstract Background Butyrogenic bacteria play an important role in gut microbiome homeostasis and intestinal epithelial integrity. Previous studies have…”
Get full text

Restrictive Versus Permissive Use of Broad-spectrum Antibiotics in Patients Receiving Allogeneic Stem Cell Transplantation and With Early Fever Due to Cytokine Release Syndrome: Evidence for Beneficial Microbiota Protection Without Increase in Infectious Complications by Weber, Daniela, Hiergeist, Andreas, Weber, Markus, Ghimire, Sakhila, Salzberger, Bernd, Wolff, Daniel, Poeck, Hendrik, Gessner, André, Edinger, Matthias, Herr, Wolfgang, Meedt, Elisabeth, Holler, Ernst

“…Abstract Background Intestinal microbiome contributes to the pathophysiology of acute gastrointestinal (GI) graft-versus-host disease (GvHD) and loss of…”
Get full text

Ruxolitinib for the treatment of acute graft-versus-host disease: a retrospective analysis by Denk, Alexander, Edinger, Matthias, Weber, Daniela, Holler, Ernst, Fante, Matthias, Meedt, Elisabeth, Gunes, Sibel, Poeck, Hendrik, Mittermaier, Cornelia, Herr, Wolfgang, Wolff, Daniel

“…Steroid-refractory acute graft-versus-host disease (aGvHD) is a serious complication after allogeneic hematopoietic stem cell transplantation, associated with…”
Get full text

Chronic Active Epstein-Barr Virus (EBV) Infection Controlled by Allogeneic Stem Cell Transplantation and EBV-Specific T Cells by Meedt, Elisabeth, Weber, Daniela, Bonifacius, Agnes, Eiz-Vesper, Britta, Maecker-Kolhoff, Britta, Delecluse, Susanne, Delecluse, Henri-Jacques, Lorenz, Myriam, Schwarz, Klaus, Meedt, Stefan T, Braess, Jan, Herr, Wolfgang, Holler, Ernst, Edinger, Matthias, Wolff, Daniel

“…Abstract We report sustained remission of chronic active Epstein-Barr virus (EBV) infection in a 27-year-old female patient treated with third-party…”
Get full text

Microbial-Derived Metabolites Induce Epithelial Recovery Via the Sting Pathway in Mice and Men and Protect from Graft-Versus-Host Disease by Thiele Orberg, Erik, Göttert, Sascha, Hiergeist, Andreas, Meedt, Elisabeth, Kleigrewe, Karin, Herr, Wolfgang, Bassermann, Florian, Gessner, Andre, Holler, Ernst, Heidegger, Simon, Poeck, Hendrik

“…Background: Graft-versus-host disease (GVHD) is a dreaded complication after allogeneic stem-cell transplantation (ASCT). Previously, we and others showed that…”
Get full text

Impact of chronic graft-versus-host-disease on intensive care outcome in allogeneic hematopoietic stem cell recipients by Lueck, Catherina, Tzalavras, Asterios, Wohlfarth, Philipp, Meedt, Elisabeth, Kiehl, Michael, Turki, Amin T., Hoeper, Marius M., Eder, Matthias, Cserna, Julia, Buchtele, Nina, Wolff, Daniel, Schellongowski, Peter, Beutel, Gernot, Liebregts, Tobias

“…Chronic graft-vs-host-disease (cGvHD) is the most relevant long-term complication after allogeneic stem cell transplantation (HSCT) with major impact on…”
Get full text

Bacterial and Bacteriophage Consortia Are Associated with Protective Intestinal Immuno-Modulatory Metabolites in Allogeneic Stem Cell Transplantation Patients by Thiele Orberg, Erik, Meedt, Elisabeth, Hiergeist, Andreas, Xue, Jinling, Heinrich, Paul, Ghimire, Sakhila, Miltiadous, Oriana, Lindner, Sarah, Schwarz, Alix, Janssen, Klaus-Peter, Herhaus, Peter, Verbeek, Mareike, van den Brink, Marcel R.M., Weber, Daniela, Edinger, Matthias, Wolff, Daniel, Kleigrewe, Karin, Herr, Wolfgang, Bassermann, Florian, Gessner, André, Deng, Li, Holler, Ernst, Poeck, Hendrik

“…The human microbiome is a predictor of clinical outcome in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-SCT). Besides bacteria,…”
Get full text

Longitudinal Analysis of Gut Bacteriome, Mycobiome, Virome and Metabolome in Allogeneic Stem Cell Transplantation Reveals Susceptibility for Acute Graft-Versus-Host Disease by Thiele Orberg, Erik, Meedt, Elisabeth, Hiergeist, Andreas, Xue, Jinling, Ghimire, Sakhila, Tiefgraber, Melanie, Eismann, Tina, Göldel, Sophia, Herhaus, Peter, Verbeek, Mareike, Bassermann, Florian, Quante, Michael, Weber, Daniela, Edinger, Matthias, Wolff, Daniel, Herr, Wolfgang, Deng, Li, Gessner, André, Holler, Ernst, Poeck, Hendrik

“…The intestinal microbiome directly effects outcomes in patients undergoing allogeneic stem cell transplantation (ASCT) (Peled et al., N Engl J Med, 2020)…”
Get full text

Identification of Bacterial and Viral Consortia for the Production of Intestinal Microbiota-Derived Metabolites Associated with Protection in Allogeneic Stem Cell Transplantation Patients by Thiele Orberg, Erik, Meedt, Elisabeth, Hiergeist, Andreas, Xue, Jinling, Heinrich, Paul, Ghimire, Sakhila, Tiefgraber, Melanie, Göldel, Sophia, Eismann, Tina, Schwarz, Alix, Jarosch, Sebastian, Steiger, Katja, Kleigrewe, Karin, Fischer, Julius Clemens, Janssen, Klaus-Peter, Quante, Michael, Heidegger, Simon, Herhaus, Peter, Verbeek, Mareike, Ruland, Jürgen, Schulz, Christian, Weber, Daniela, Edinger, Matthias, Wolff, Daniel, Busch, Dirk, Herr, Wolfgang, Bassermann, Florian, Deng, Li, Gessner, Andre, Holler, Ernst, Poeck, Hendrik

Get full text

Prognostic Value of Elafin in Acute Graft-Versus-Host Disease by Zewde, Makda Getachew, Morales, George, Gandhi, Isha, Ozbek, Umut, Aguayo-Hiraldo, Paibel, Ayuk, Francis A., Baez, Janna, Chanswangphuwana, Chantiya, Choe, Hannah, DeFilipp, Zachariah, Etra, Aaron, Grupp, Stephan A., Hexner, Elizabeth O., Hogan, William J, Javorniczky, Rebeka, Kasikis, Stelios, Kitko, Carrie Lynn, Kowalyk, Steven, Meedt, Elisabeth, Merli, Pietro, Nakamura, Ryotaro, Qayed, Muna, Reshef, Ran, Roesler, Wolf, Schechter-Finkelstein, Tal, Weber, Daniela, Wölfl, Matthias, Yanik, Gregory A, Young, Rachel, Levine, John E., Ferrara, James L., Chen, Yi-Bin

“…Background: A major cause of mortality in patients receiving hematopoietic stem cell transplantation (HCT) is acute graft-versus-host disease (GVHD), a…”
Get full text

Restrictive versus permissive use of broad-spectrum antibiotics in patients receiving allogeneic SCT and early fever due to cytokine release syndrome: Evidence for beneficial microbiota protection without increase of infectious complications by Weber, Daniela, Hiergeist, Andreas, Weber, Markus, Ghimire, Sakhila, Salzberger, Bernd, Wolff, Daniel, Poeck, Hendrik, Gessner, André, Edinger, Matthias, Herr, Wolfgang, Meedt, Elisabeth, Holler, Ernst

“…Intestinal microbiota contribute to the pathophysiology of acute gastrointestinal (GI) Graft-versus-Host Disease (aGvHD) and loss of microbiome diversity…”
Get full text

Multimodal immune cell phenotyping in GI biopsies reveals microbiome-related T cell modulations in human GvHD by Jarosch, Sebastian, Köhlen, Jan, Ghimire, Sakhila, Orberg, Erik Thiele, Hammel, Monika, Gaag, Doris, Evert, Matthias, Janssen, Klaus-Peter, Hiergeist, Andreas, Gessner, André, Weber, Daniela, Meedt, Elisabeth, Poeck, Hendrik, D’Ippolito, Elvira, Holler, Ernst, Busch, Dirk H.

“…Acute graft-versus-host disease (aGvHD) is a significant complication after allogeneic hematopoietic stem cell transplantation (aHSCT), but major factors…”
Get full text

Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation by Thiele Orberg, Erik, Meedt, Elisabeth, Hiergeist, Andreas, Xue, Jinling, Heinrich, Paul, Ru, Jinlong, Ghimire, Sakhila, Miltiadous, Oriana, Lindner, Sarah, Tiefgraber, Melanie, Göldel, Sophia, Eismann, Tina, Schwarz, Alix, Göttert, Sascha, Jarosch, Sebastian, Steiger, Katja, Schulz, Christian, Gigl, Michael, Fischer, Julius C, Janssen, Klaus-Peter, Quante, Michael, Heidegger, Simon, Herhaus, Peter, Verbeek, Mareike, Ruland, Jürgen, van den Brink, Marcel R M, Weber, Daniela, Edinger, Matthias, Wolff, Daniel, Busch, Dirk H, Kleigrewe, Karin, Herr, Wolfgang, Bassermann, Florian, Gessner, André, Deng, Li, Holler, Ernst, Poeck, Hendrik

“…The microbiome is a predictor of clinical outcome in patients receiving allogeneic hematopoietic stem cell transplantation (allo-SCT). Microbiota-derived…”
Get full text

Reg3α concentrations at day of allogeneic stem cell transplantation predict outcome and correlate with early antibiotic use by Weber, Daniela, Weber, Markus, Meedt, Elisabeth, Ghimire, Sakhila, Wolff, Daniel, Edinger, Matthias, Poeck, Hendrik, Hiergeist, Andreas, Gessner, André, Ayuk, Francis, Roesler, Wolf, Wölfl, Matthias, Kraus, Sabrina, Zeiser, Robert, Bertrand, Hannah, Bader, Peter, Ullrich, Evelyn, Eder, Matthias, Gleich, Sigrun, Young, Rachel, Herr, Wolfgang, Levine, John E., Ferrara, James L. M., Holler, Ernst

“…•Reg3α concentrations on day of graft infusion predict outcome after ASCT.•Reg3α concentrations are influenced by intestinal dysbiosis induced by early AB use…”
Get full text

Evaluation of Elafin as a Prognostic Biomarker in Acute Graft-versus-Host Disease by Zewde, Makda Getachew, Morales, George, Gandhi, Isha, Özbek, Umut, Aguayo-Hiraldo, Paibel, Ayuk, Francis, Baez, Janna, Chanswangphuwana, Chantiya, Choe, Hannah, DeFilipp, Zachariah, Etra, Aaron, Grupp, Stephan, Hexner, Elizabeth O., Hogan, William, Javorniczky, Nora Rebeka, Kasikis, Stelios, Kitko, Carrie L., Kowalyk, Steven, Meedt, Elisabeth, Merli, Pietro, Nakamura, Ryotaro, Qayed, Muna, Reshef, Ran, Rösler, Wolf, Schechter, Tal, Weber, Daniela, Wölfl, Matthias, Yanik, Gregory, Young, Rachel, Levine, John E., Ferrara, James L.M., Chen, Yi-Bin

“…•Serum elafin concentrations do not predict 6-month nonrelapse mortality (NRM), overall survival (OS), or treatment response in recipients of hematopoietic…”
Get full text