Search Results - "Meechoovet, Bessie"

Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo by Bouchareychas, Laura, Duong, Phat, Covarrubias, Sergio, Alsop, Eric, Phu, Tuan Anh, Chung, Allen, Gomes, Michael, Wong, David, Meechoovet, Bessie, Capili, Allyson, Yamamoto, Ryo, Nakauchi, Hiromitsu, McManus, Michael T., Carpenter, Susan, Van Keuren-Jensen, Kendall, Raffai, Robert L.

“…Developing strategies that promote the resolution of vascular inflammation and atherosclerosis remains a major therapeutic challenge. Here, we show that…”
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β-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer's disease-related sites by Frost, Danielle, Meechoovet, Bessie, Wang, Tong, Gately, Stephen, Giorgetti, Marco, Shcherbakova, Irina, Dunckley, Travis

“…Harmine, a β-carboline alkaloid, is a high affinity inhibitor of the dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) protein. The DYRK1A…”
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Dyrk1 inhibition improves Alzheimer's disease‐like pathology by Branca, Caterina, Shaw, Darren M., Belfiore, Ramona, Gokhale, Vijay, Shaw, Arthur Y., Foley, Christopher, Smith, Breland, Hulme, Christopher, Dunckley, Travis, Meechoovet, Bessie, Caccamo, Antonella, Oddo, Salvatore

“…Summary There is an urgent need for the development of new therapeutic strategies for Alzheimer's disease (AD). The dual‐specificity tyrosine…”
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DNA Methylation and Expression Profiles of Whole Blood in Parkinson's Disease by Henderson, Adrienne R, Wang, Qi, Meechoovet, Bessie, Siniard, Ashley L, Naymik, Marcus, De Both, Matthew, Huentelman, Matthew J, Caselli, Richard J, Driver-Dunckley, Erika, Dunckley, Travis

“…Parkinson's disease (PD) is the second most common age-related neurodegenerative disease. It is presently only accurately diagnosed at an advanced stage by a…”
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Single molecule characterization of individual extracellular vesicles from pancreatic cancer by Lennon, Kathleen M., Wakefield, Devin L., Maddox, Adam L., Brehove, Matthew S., Willner, Ari N., Garcia-Mansfield, Krystine, Meechoovet, Bessie, Reiman, Rebecca, Hutchins, Elizabeth, Miller, Marcia M., Goel, Ajay, Pirrotte, Patrick, Van Keuren-Jensen, Kendall, Jovanovic-Talisman, Tijana

“…Biofluid-accessible extracellular vesicles (EVs) may represent a new means to improve the sensitivity and specificity of detecting disease. However, current…”
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High glucose macrophage exosomes enhance atherosclerosis by driving cellular proliferation & hematopoiesis by Bouchareychas, Laura, Duong, Phat, Phu, Tuan Anh, Alsop, Eric, Meechoovet, Bessie, Reiman, Rebecca, Ng, Martin, Yamamoto, Ryo, Nakauchi, Hiromitsu, Gasper, Warren J., Van Keuren-Jensen, Kendall, Raffai, Robert L.

“…We investigated whether extracellular vesicles (EVs) produced under hyperglycemic conditions could communicate signaling to drive atherosclerosis. We did so by…”
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Extracellular microRNAs in blood differentiate between ischaemic and haemorrhagic stroke subtypes by Kalani, M. Yashar S., Alsop, Eric, Meechoovet, Bessie, Beecroft, Taylor, Agrawal, Komal, Whitsett, Timothy G., Huentelman, Matthew J., Spetzler, Robert F., Nakaji, Peter, Kim, Seungchan, Van Keuren-Jensen, Kendall

“…Rapid identification of patients suffering from cerebral ischaemia, while excluding intracerebral haemorrhage, can assist with patient triage and expand…”
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A Novel Tissue Atlas and Online Tool for the Interrogation of Small RNA Expression in Human Tissues and Biofluids by Alsop, Eric, Meechoovet, Bessie, Kitchen, Robert, Sweeney, Thadryan, Beach, Thomas G, Serrano, Geidy E, Hutchins, Elizabeth, Ghiran, Ionita, Reiman, Rebecca, Syring, Michael, Hsieh, Michael, Courtright-Lim, Amanda, Valkov, Nedyalka, Whitsett, Timothy G, Rakela, Jorge, Pockros, Paul, Rozowsky, Joel, Gallego, Juan, Huentelman, Matthew J, Shah, Ravi, Nakaji, Peter, Kalani, M Yashar S, Laurent, Louise, Das, Saumya, Van Keuren-Jensen, Kendall

“…One promising goal for utilizing the molecular information circulating in biofluids is the discovery of clinically useful biomarkers. Extracellular RNAs…”
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SMG1 identified as a regulator of Parkinson's disease-associated alpha-synuclein through siRNA screening by Henderson-Smith, Adrienne, Chow, Donald, Meechoovet, Bessie, Aziz, Meraj, Jacobson, Sandra A, Shill, Holly A, Sabbagh, Marwan N, Caviness, John N, Adler, Charles H, Driver-Dunckley, Erika D, Beach, Thomas G, Yin, Hongwei, Dunckley, Travis

“…Synucleinopathies are a broad class of neurodegenerative disorders characterized by the presence of intracellular protein aggregates containing α-synuclein…”
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Association between GAB2 haplotype and higher glucose metabolism in Alzheimer's disease-affected brain regions in cognitively normal APOEε4 carriers by Liang, Winnie S., Chen, Kewei, Lee, Wendy, Sidhar, Kunal, Corneveaux, Jason J., Allen, April N., Myers, Amanda, Villa, Stephen, Meechoovet, Bessie, Pruzin, Jeremy, Bandy, Daniel, Fleisher, Adam S., Langbaum, Jessica B.S., Huentelman, Matthew J., Jensen, Kendall, Dunckley, Travis, Caselli, Richard J., Kaib, Susan, Reiman, Eric M.

“…In a genome-wide association study (GWAS) of late-onset Alzheimer's disease (AD), we found an association between common haplotypes of the GAB2 gene and AD…”
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Mir-30d Regulates Cardiac Remodeling by Intracellular and Paracrine Signaling by Li, Jin, Salvador, Ane M., Li, Guoping, Valkov, Nedyalka, Ziegler, Olivia, Yeri, Ashish, Yang Xiao, Chun, Meechoovet, Bessie, Alsop, Eric, Rodosthenous, Rodosthenis S., Kundu, Piyusha, Huan, Tianxiao, Levy, Daniel, Tigges, John, Pico, Alexander R., Ghiran, Ionita, Silverman, Michael G., Meng, Xiangmin, Kitchen, Robert, Xu, Jiahong, Van Keuren-Jensen, Kendall, Shah, Ravi, Xiao, Junjie, Das, Saumya

“…Previous translational studies implicate plasma extracellular microRNA-30d (miR-30d) as a biomarker in left ventricular remodeling and clinical outcome in…”
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CARDIOVESICLES: A LIQUID BIOPSY TECHNOLOGY FOR HEART FAILURE AND CARDIOVASCULAR DISEASES by Spanos, Michail, Gokulnath, Priyanka, Li, Guoping, Hutchins, Elizabeth, Meechoovet, Bessie, Pirrotte, Patrick, Azzam, Christopher, Ulrich, Bryan, Chatterjee, Emeli, Abuelreich, Sarah, Saftics, Andras, Varrias, Dimitrios, Spanos, Anastasios, Jovanovic-Talisman, Tijana, Van Keuren-Jensen, Kendall, Shah, Ravi, Das, Saumya

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Abstract 17293: Hyperglycemia Enhances Pro-Inflammatory Properties of Macrophage-Derived Exosomes to Drive Hematopoiesis in Apolipoprotein E-Deficient Mouse by Bouchareychas, Laura, Duong, Phat, Phu, Tuan Anh, Alsop, Eric, meechoovet, bessie, Yamamoto, Ryo, Nakauchi, Hiromitsu, Van Keuren-Jensen, kendall, Raffai, Robert

“…IntroductionMacrophage-derived exosomes have emerged as important mediators in cell-to-cell communication by influencing inflammatory signaling and the immune…”
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The Presence of Select Tau Species in Human Peripheral Tissues and Their Relation to Alzheimer's Disease by Dugger, Brittany N, Whiteside, Charisse M, Maarouf, Chera L, Walker, Douglas G, Beach, Thomas G, Sue, Lucia I, Garcia, Angelica, Dunckley, Travis, Meechoovet, Bessie, Reiman, Eric M, Roher, Alex E

“…Tau becomes excessively phosphorylated in Alzheimer's disease (AD) and is widely studied within the brain. Further examination of the extent and types of tau…”
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Dynamic transcriptomic responses to divergent acute exercise stimuli in young adults by Lavin, Kaleen M, Graham, Zachary A, McAdam, Jeremy S, O'Bryan, Samia M, Drummer, Devin, Bell, Margaret B, Kelley, Christian J, Lixandrão, Manoel E, Peoples, Brandon, Tuggle, S Craig, Seay, Regina S, Van Keuren-Jensen, Kendall, Huentelman, Matthew J, Pirrotte, Patrick, Reiman, Rebecca, Alsop, Eric, Hutchins, Elizabeth, Antone, Jerry, Bonfitto, Anna, Meechoovet, Bessie, Palade, Joanna, Talboom, Joshua S, Sullivan, Amber, Aban, Inmaculada, Peri, Kalyani, Broderick, Timothy J, Bamman, Marcas M

“…Acute exercise elicits dynamic transcriptional changes that, when repeated, form the fundamental basis of health, resilience, and performance adaptations…”
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The Foundational Data Initiative for Parkinson Disease: Enabling efficient translation from genetic maps to mechanism by Bressan, Elisangela, Reed, Xylena, Bansal, Vikas, Hutchins, Elizabeth, Cobb, Melanie M., Webb, Michelle G., Alsop, Eric, Grenn, Francis P., Illarionova, Anastasia, Savytska, Natalia, Violich, Ivo, Broeer, Stefanie, Fernandes, Noémia, Sivakumar, Ramiyapriya, Beilina, Alexandra, Billingsley, Kimberley J., Berghausen, Joos, Pantazis, Caroline B., Pitz, Vanessa, Patel, Dhairya, Daida, Kensuke, Meechoovet, Bessie, Reiman, Rebecca, Courtright-Lim, Amanda, Logemann, Amber, Antone, Jerry, Barch, Mariya, Kitchen, Robert, Li, Yan, Dalgard, Clifton L., Rizzu, Patrizia, Hernandez, Dena G., Hjelm, Brooke E., Nalls, Mike, Gibbs, J. Raphael, Finkbeiner, Steven, Cookson, Mark R., Van Keuren-Jensen, Kendall, Craig, David W., Singleton, Andrew B., Heutink, Peter, Blauwendraat, Cornelis

“…The Foundational Data Initiative for Parkinson Disease (FOUNDIN-PD) is an international collaboration producing fundamental resources for Parkinson disease…”
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A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B) by François-Moutal, Liberty, Jahanbakhsh, Shahriyar, Nelson, Andrew D. L, Ray, Debashish, Scott, David D, Hennefarth, Matthew R, Moutal, Aubin, Perez-Miller, Samantha, Ambrose, Andrew J, Al-Shamari, Ahmed, Coursodon, Philippe, Meechoovet, Bessie, Reiman, Rebecca, Lyons, Eric, Beilstein, Mark, Chapman, Eli, Morris, Quaid D, Van Keuren-Jensen, Kendall, Hughes, Timothy R, Khanna, Rajesh, Koehler, Carla, Jen, Joanna, Gokhale, Vijay, Khanna, May

“…Mutations of EXOSC3 have been linked to the rare neurological disorder known as Pontocerebellar Hypoplasia type 1B (PCH1B). EXOSC3 is one of three putative…”
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Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer's Disease-Related Sites by Frost, Danielle, Meechoovet, Bessie, Wang, Tong, Gately, Stephen, Giorgetti, Marco, Shcherbakova, Irina, Dunckley, Travis

“…Harmine, a [beta]-carboline alkaloid, is a high affinity inhibitor of the dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) protein. The…”
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Association between GAB2 haplotype and higher glucose metabolism in Alzheimer's disease-affected brain regions in cognitively normal APOE[epsilon]4 carriers by Liang, Winnie S, Chen, Kewei, Lee, Wendy, Sidhar, Kunal, Corneveaux, Jason J, Allen, April N, Myers, Amanda, Villa, Stephen, Meechoovet, Bessie, Pruzin, Jeremy, Bandy, Daniel, Fleisher, Adam S, Langbaum, Jessica BS, Huentelman, Matthew J, Jensen, Kendall, Dunckley, Travis, Caselli, Richard J, Kaib, Susan, Reiman, Eric M

“…In a genome-wide association study (GWAS) of late-onset Alzheimer's disease (AD), we found an association between common haplotypes of the GAB2 gene and AD…”
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Corrigendum to “Association between GAB2 haplotype and higher glucose metabolism in Alzheimer's disease-affected brain regions in cognitively normal APOEε4 carriers” [NeuroImage 54/3 (2011) 1896–1902] by Liang, Winnie S., Chen, Kewei, Lee, Wendy, Sidhar, Kunal, Corneveaux, Jason J., Allen, April N., Myers, Amanda, Villa, Stephen, Meechoovet, Bessie, Pruzin, Jeremy, Bandy, Daniel, Fleisher, Adam S., Langbaum, Jessica B.S., Huentelman, Matthew J., Jensen, Kendall, Dunckley, Travis, Caselli, Richard J., Kaib, Susan, Reiman, Eric M.

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