Conditioned place aversion produced by dopamine release inhibition

Conditioned place aversion produced by dopamine release inhibition

CGS 10746B, a dopamine release inhibitor with properties similar to the atypical antipsychotic clozapine, was assessed as to its behavioral properties using spontaneous locomotor activity and the conditioned place preference test. Rats conditioned with interperitoneally administered doses of 1.25, 2...

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Bibliographic Details
Published in:European journal of pharmacology Vol. 260; no. 2-3; p. 133
Main Authors: Schechter, M D, Meechan, S M
Format: Journal Article
Language:English
Published: Netherlands 01-08-1994
Subjects:
Analysis of Variance
Animals
Antipsychotic Agents - administration & dosage
Antipsychotic Agents - pharmacology
Aversive Therapy
Conditioning (Psychology)
Disease Models, Animal
Dopamine Antagonists - administration & dosage
Dopamine Antagonists - pharmacology
Dose-Response Relationship, Drug
Injections, Intraperitoneal
Male
Motor Activity - drug effects
Random Allocation
Rats
Rats, Sprague-Dawley
Thiazepines - administration & dosage
Thiazepines - pharmacology
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Summary:CGS 10746B, a dopamine release inhibitor with properties similar to the atypical antipsychotic clozapine, was assessed as to its behavioral properties using spontaneous locomotor activity and the conditioned place preference test. Rats conditioned with interperitoneally administered doses of 1.25, 2.5, 5.0, 10.0, 20.0 or 30.0 mg/kg CGS 10746B showed a conditioned place aversion, whereas only doses of 5.0 mg/kg or greater suppressed locomotor activity. Results are discussed in terms of dopaminergic mediation of conditioned place preference and spontaneous locomotor activity and methodological concerns involved in employing the conditioned place preference test with drugs that produce opposing affective cues.
ISSN:0014-2999
DOI:10.1016/0014-2999(94)90329-8