Search Results - "Meechan, D W"
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Cognitive ability is associated with altered medial frontal cortical circuits in the LgDel mouse model of 22q11.2DS
Published in Cerebral cortex (New York, N.Y. 1991) (01-05-2015)“…We established a relationship between cognitive deficits and cortical circuits in the LgDel model of 22q11 Deletion Syndrome (22q11DS)-a genetic syndrome with…”
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Limited influence of olanzapine on adult forebrain neural precursors in vitro
Published in Neuroscience (01-01-2006)“…We evaluated the activity of the atypical antipsychotic drug olanzapine on differentiation and gene expression in adult neural precursor cells in vitro. Neural…”
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Single nucleotide polymorphisms in the leptin receptor gene: studies in anorexia nervosa
Published in Psychiatric genetics (01-12-2004)“…Anorexia nervosa is an eating disorder of unknown aetiology. There is significant evidence for a genetic component in the pathogenesis of this disorder. A…”
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Three phases of DiGeorge/22q11 deletion syndrome pathogenesis during brain development: Patterning, proliferation, and mitochondrial functions of 22q11 genes
Published in International journal of developmental neuroscience (01-05-2011)“…▶ 22q11DS genes are expressed embryonically at mesenychmal/epithelial induction sites. ▶ Embryonic neurogenesis and neuronal migration are altered in a model…”
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Mitochondrial localization and function of a subset of 22q11 deletion syndrome candidate genes
Published in Molecular and cellular neuroscience (29-10-2008)“…Six genes in the 1.5 Mb region of chromosome 22 deleted in DiGeorge/22q11 deletion syndrome– Mrpl40, Prodh, Slc25a1, Txnrd2, T10, and Zdhhc8–encode…”
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Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin‐releasing hormone (GnRH) neurons
Published in Developmental dynamics (01-06-2010)“…We asked whether specific mesenchymal/epithelial (M/E) induction generates olfactory receptor neurons (ORNs), vomeronasal neurons (VRNs), and…”
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Gene dosage in the developing and adult brain in a mouse model of 22q11 deletion syndrome
Published in Molecular and cellular neuroscience (15-12-2006)“…We evaluated the consequences of heterozygous chromosome 22q11 deletion – a significant genetic risk for schizophrenia – for expression levels and patterns of…”
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When Half Is Not Enough: Gene Expression and Dosage in the 22q11 Deletion Syndrome
Published in Gene expression (01-01-2007)“…The 22q11 Deletion Syndrome (22q11DS, also known as DiGeorge or Velo-Cardio-Facial Syndrome) has a variable constellation of phenotypes including…”
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Cortical interneurons require Jnk1 to enter and navigate the developing cerebral cortex
Published in The Journal of neuroscience (04-06-2014)“…Proper assembly of cortical circuitry relies on the correct migration of cortical interneurons from their place of birth in the ganglionic eminences to their…”
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22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development
Published in Human molecular genetics (15-01-2013)“…We asked whether key morphogenetic signaling pathways interact with 22q11 gene dosage to modulate the severity of cranial or cardiac anomalies in DiGeorge/22q1…”
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Mitochondral localization and function of a subset of 22q11 Deletion Syndrome candidate genes
Published in Molecular and cellular neuroscience (15-08-2008)“…Six genes in the 1.5 MB region of chromosome 22 deleted in DiGeorge/22q11 Deletion Syndrome— Mrpl40, Prodh, Slc25a1, Txnrd2, T10 , and Zdhhc8 —encode…”
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