Search Results - "Medrano, Estela E."

The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation by Jin, Jingling, Iakova, Polina, Jiang, Yanjun, Medrano, Estela E., Timchenko, Nikolai A.

“…Age declines liver functions, leading to the development of age‐associated diseases. A member of the sirtuins family, SIRT1, is involved in the control of…”
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Role of HDAC1 in senescence, aging, and cancer by Willis-Martinez, Danielle, Richards, Hunter W., Timchenko, Nikolai A., Medrano, Estela E.

“…HDAC1 is a member of the class I of histone deacetylases that also includes HDAC2, -3 and -8. Although HDAC1 has been mostly studied in the context of cancer,…”
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Overexpression of histone deacetylase 1 confers resistance to sodium butyrate-mediated apoptosis in melanoma cells through a p53-mediated pathway by BANDYOPADHYAY, Debdutta, MISHRA, Anupam, MEDRANO, Estela E

“…Melanoma cells typically express wild-type p53, yet they are notoriously resistant to DNA-damaging agents. Here, we show that sodium butyrate (NaB), a histone…”
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Inhibition of xenografted human melanoma growth and prevention of metastasis development by dual antiangiogenic/antitumor activities of pigment epithelium-derived factor by GARCIA, Marta, FERNANDEZ-GARCIA, Nuria Isabel, LARCHER, Fernando, DEL RIO, Marcela, RIVAS, Veronica, CARRETERO, Marta, ESCAMEZ, Maria J, GONZALEZ-MARTIN, Alicia, MEDRANO, Estela E, VOLPERT, Olga, JORCANO, Jose L, JIMENEZ, Benilde

“…Human melanoma mortality is associated with the growth of metastasis in selected organs including the lungs, liver, and brain. In this study, we examined the…”
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SKI knockdown inhibits human melanoma tumor growth in vivo by Chen, Dahu, Lin, Qiushi, Box, Neil, Roop, Dennis, Ishii, Shunsuke, Matsuzaki, Koichi, Fan, Tao, Hornyak, Thomas J., Reed, Jon A, Stavnezer, Ed, Timchenko, Nikolai A., Medrano, Estela E.

“…Summary The SKI protein represses the TGF‐β tumor suppressor pathway by associating with the Smad transcription factors. SKI is upregulated in human malignant…”
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SKI pathways inducing progression of human melanoma by Reed, Jon A, Lin, Qiushi, Chen, Dahu, Mian, I Saira, Medrano, Estela E

“…The proteins SKI and SnoN are implicated in processes as diverse as differentiation, transformation and tumor progression. Until recently, SKI was solely…”
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The low molecular weight cyclin E isoforms augment angiogenesis and metastasis of human melanoma cells in vivo by BALES, Elise, MILLS, Lisa, KEYOMARSI, Khandan, MEDRANO, Estela E, MILAM, Nancy, MCGAHREN-MURRAY, Mollianne, BANDYOPADHYAY, Debdutta, DAHU CHEN, REED, Jon A, TIMCHENKO, Nikolai, VAN DEN OORD, Joost J, BAR-ELI, Menashe

“…Immunohistochemical analysis has consistently shown that cyclin E is up-regulated in human malignant melanomas in vivo. Here we analyzed such expression in…”
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β-N-Acetylglucosamine (O-GlcNAc) Is a Novel Regulator of Mitosis-specific Phosphorylations on Histone H3 by Fong, Jerry J., Nguyen, Brenda L., Bridger, Robert, Medrano, Estela E., Wells, Lance, Pan, Shujuan, Sifers, Richard N.

“…O-Linked β-N-acetylglucosamine, or O-GlcNAc, is a dynamic post-translational modification that cycles on and off serine and threonine residues of…”
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Inhibition of proliferation and survival of melanoma cells by adenoviral-mediated expression of dominant negative fibroblast growth factor receptor by Ozen, Mustafa, Medrano, Estela E, Ittmann, Michael

“…Melanoma is the most deadly cutaneous malignancy; its incidence has risen significantly over the last 30 years and there is no effective treatment for advanced…”
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HDAC1 Cooperates with C/EBPα in the Inhibition of Liver Proliferation in Old Mice by Wang, Guo-Li, Salisbury, Elizabeth, Shi, Xiurong, Timchenko, Lubov, Medrano, Estela E., Timchenko, Nikolai A.

“…Epigenetic control of liver proliferation involves cooperation between transcription factors and chromatin-remodeling proteins. In this work, we found that the…”
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H3K79me3T80ph is a Novel Histone Dual Modification and a Mitotic Indicator in Melanoma by Richards, Hunter W., Martinez, Danielle R., Lin, Qiushi, Torres-Cabala, Carlos A., Prieto, Victor G., Curry, Jonathan L., Medrano, Estela E.

“…The current study characterizes the mitosis-associated histone dual modification on the core of histone H3: trimethylation of histone H3 lysine 79 and…”
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The Cytotoxicity and Apoptosis Induced by 4-Tertiary Butylphenol in Human Melanocytes are Independent of Tyrosinase Activity by Yang, Fan, Sarangarajan, Rangaprasad, Caroline Le Poole, I., Boissy, Raymond E., Medrano, Estela E.

“…It has been known for several decades that cutaneous depigmentation, i.e., contact/occupational vitiligo, can be caused by some phenolic derivatives that have…”
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Repression of TGF-beta signaling by the oncogenic protein SKI in human melanomas: consequences for proliferation, survival, and metastasis by Medrano, Estela E

“…Transforming growth factor-beta (TGF-beta ) has dual and paradoxical functions as a tumor suppressor and promoter of tumor progression and metastasis…”
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HDAC1 Promotes Liver Proliferation in Young Mice via Interactions with C/EBPβ by Wang, Guo-Li, Salisbury, Elizabeth, Shi, Xiurong, Timchenko, Lubov, Medrano, Estela E., Timchenko, Nikolai A.

“…HDAC1 (histone deacetylase 1) regulates a number of biological processes in cells. Our previous studies revealed that HDAC1 inhibits proliferation of the…”
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Not quite as old as the sun by Medrano, Estela E.

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Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi by Bandyopadhyay, Debdutta, Curry, Jonathan L., Lin, Qiushi, Richards, Hunter W., Chen, Dahu, Hornsby, Peter J., Timchenko, Nikolai A., Medrano, Estela E.

“…Summary The retinoblastoma (RB)/p16INK4a pathway regulates senescence of human melanocytes in culture and oncogene‐induced senescence of melanocytic nevi in…”
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The emerging role of epigenetics in cellular and organismal aging by Bandyopadhyay, Debdutta, Medrano, Estela E

“…Genome modifications resulting from epigenetic changes appear to play a critical role in the development and/or progression of cancer. Scatter experimental…”
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Epigenetic marks in melanoma by Richards, Hunter W., Medrano, Estela E.

“…Summary Melanoma is a highly heterogeneous cancer that comes in different flavors (lentigo maligna melanoma, superficial spreading melanoma, nodular melanoma,…”
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Down-regulation of p300/CBP histone acetyltransferase activates a senescence checkpoint in human melanocytes by BANDYOPADHYAY, Debdutta, OKAN, Nihal A, BALES, Elise, NASCIMENTO, Lucia, COLE, Philip A, MEDRANO, Estela E

“…The histone acetyltransferases p300 and cAMP-responsive element-binding protein-binding protein (CBP) are required for the execution of critical biological…”
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SKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGF-β by Lin, Qiushi, Chen, Dahu, Timchenko, Nikolai A., Medrano, Estela E.

“…The transcriptional co-regulator SKI is a potent inhibitor of TGF-β-growth inhibitory signals. SKI binds to receptor-activated Smads in the nucleus, forming…”
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