Search Results - "Medoh, Uche N."

The Bis(monoacylglycero)-phosphate Hypothesis: From Lysosomal Function to Therapeutic Avenues by Medoh, Uche N, Abu-Remaileh, Monther

“…Lysosomes catabolize and recycle lipids and other biological molecules to maintain cellular homeostasis in diverse nutrient environments. Lysosomal lipid…”
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The Batten disease gene product CLN5 is the lysosomal bis(monoacylglycero)phosphate synthase by Medoh, Uche N, Hims, Andy, Chen, Julie Y, Ghoochani, Ali, Nyame, Kwamina, Dong, Wentao, Abu-Remaileh, Monther

“…Lysosomes critically rely on bis(monoacylglycero)phosphate (BMP) to stimulate lipid catabolism, cholesterol homeostasis, and lysosomal function. Alterations in…”
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CLN3 is required for the clearance of glycerophosphodiesters from lysosomes by Laqtom, Nouf N., Dong, Wentao, Medoh, Uche N., Cangelosi, Andrew L., Dharamdasani, Vimisha, Chan, Sze Ham, Kunchok, Tenzin, Lewis, Caroline A., Heinze, Ivonne, Tang, Rachel, Grimm, Christian, Dang Do, An N., Porter, Forbes D., Ori, Alessandro, Sabatini, David M., Abu-Remaileh, Monther

“…Lysosomes have many roles, including degrading macromolecules and signalling to the nucleus 1 . Lysosomal dysfunction occurs in various human conditions, such…”
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Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease by Nyame, Kwamina, Hims, Andy, Aburous, Aya, Laqtom, Nouf N, Dong, Wentao, Medoh, Uche N, Heiby, Julia C, Xiong, Jian, Ori, Alessandro, Abu-Remaileh, Monther

“…Batten disease, the most prevalent form of neurodegeneration in children, is caused by mutations in the CLN3 gene, which encodes a lysosomal transmembrane…”
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Lessons from metabolic perturbations in lysosomal storage disorders for neurodegeneration by Medoh, Uche N., Chen, Julie Y., Abu-Remaileh, Monther

“…Age-related neurodegenerative diseases are a clinically unmet need with unabated prevalence around the world. Several genetic studies link these diseases with…”
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