Search Results - "Medlar, Alan"

AAI-profiler: fast proteome-wide exploratory analysis reveals taxonomic identity, misclassification and contamination by Medlar, Alan J, Törönen, Petri, Holm, Liisa

“…Abstract We present AAI-profiler, a web server for exploratory analysis and quality control in comparative genomics. AAI-profiler summarizes proteome-wide…”
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Wasabi: An Integrated Platform for Evolutionary Sequence Analysis and Data Visualization by Veidenberg, Andres, Medlar, Alan, Löytynoja, Ari

“…Wasabi is an open source, web-based environment for evolutionary sequence analysis. Wasabi visualizes sequence data together with a phylogenetic tree within a…”
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TOPAZ: asymmetric suffix array neighbourhood search for massive protein databases by Medlar, Alan, Holm, Liisa

“…Protein homology search is an important, yet time-consuming, step in everything from protein annotation to metagenomics. Its application, however, has become…”
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Mutations in the autoregulatory domain of β-tubulin 4a cause hereditary dystonia by Hersheson, Joshua, Mencacci, Niccolo E., Davis, Mary, MacDonald, Nicola, Trabzuni, Daniah, Ryten, Mina, Pittman, Alan, Paudel, Reema, Kara, Eleanna, Fawcett, Katherine, Plagnol, Vincent, Bhatia, Kailash P., Medlar, Alan J., Stanescu, Horia C., Hardy, John, Kleta, Robert, Wood, Nicholas W., Houlden, Henry

“…Dystonia type 4 (DYT4) was first described in a large family from Heacham in Norfolk with an autosomal dominantly inherited whispering dysphonia, generalized…”
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Phospholipase A2 Receptor (PLA2R1) Sequence Variants in Idiopathic Membranous Nephropathy by COENEN, Marieke J. H, HOFSTRA, Julia M, MATHIESON, Peter W, BRENCHLEY, Paul E, KLETA, Robert, WETZELS, Jack F. M, RONCO, Pierre, DEBIEC, Hanna, STANESCU, Horia C, MEDLAR, Alan J, STENGEL, Bénédicte, BOLAND-AUGE, Anne, GROOTHUISMINK, Johanne M, BOCKENHAUER, Detlef, POWIS, Steve H

“…The M-type receptor for phospholipase A2 (PLA2R1) is the major target antigen in idiopathic membranous nephropathy (iMN). Our recent genome-wide association…”
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Genetic testing in renal disease by Bockenhauer, Detlef, Medlar, Alan J., Ashton, Emma, Kleta, Robert, Lench, Nick

“…A revolution is happening in genetics! The decoding of the first genome in 2003 was a large international collaborative effort that took about 13 years at a…”
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PANNZER2: a rapid functional annotation web server by Törönen, Petri, Medlar, Alan, Holm, Liisa

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Autoinflammatory periodic fever, immunodeficiency, and thrombocytopenia (PFIT) caused by mutation in actin-regulatory gene WDR1 by Standing, Ariane S I, Malinova, Dessislava, Hong, Ying, Record, Julien, Moulding, Dale, Blundell, Michael P, Nowak, Karolin, Jones, Hannah, Omoyinmi, Ebun, Gilmour, Kimberly C, Medlar, Alan, Stanescu, Horia, Kleta, Robert, Anderson, Glenn, Nanthapisal, Sira, Gomes, Sonia Melo, Klein, Nigel, Eleftheriou, Despina, Thrasher, Adrian J, Brogan, Paul A

“…The importance of actin dynamics in the activation of the inflammasome is becoming increasingly apparent. IL-1β, which is activated by the inflammasome, is…”
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PANNZER2: a rapid functional annotation web server by Törönen, Petri, Medlar, Alan, Holm, Liisa

“…Abstract The unprecedented growth of high-throughput sequencing has led to an ever-widening annotation gap in protein databases. While computational prediction…”
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Opportunities and challenges in metabarcoding approaches for helminth community identification in wild mammals by Aivelo, Tuomas, Medlar, Alan

“…Despite metabarcoding being widely used to analyse bacterial community composition, its application in parasitological research remains limited. What interest…”
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Lexical ambiguity detection in professional discourse by Liu, Yang, Medlar, Alan, Głowacka, Dorota

“…Professional discourse is the language used by specialists, such as lawyers, doctors and academics, to communicate the knowledge and assumptions associated…”
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HaploForge: a comprehensive pedigree drawing and haplotype visualization web application by Tekman, Mehmet, Medlar, Alan, Mozere, Monika, Kleta, Robert, Stanescu, Horia

“…Haplotype reconstruction is an important tool for understanding the aetiology of human disease. Haplotyping infers the most likely phase of observed genotypes…”
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Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy by Stanescu, Horia C, Arcos-Burgos, Mauricio, Medlar, Alan, Bockenhauer, Detlef, Kottgen, Anna, Dragomirescu, Liviu, Voinescu, Catalin, Patel, Naina, Pearce, Kerra, Hubank, Mike, Stephens, Henry A F, Laundy, Valerie, Padmanabhan, Sandosh, Zawadzka, Anna, Hofstra, Julia M, Coenen, Marieke J H, den Heijer, Martin, Kiemeney, Lambertus A L M, Bacq-Daian, Delphine, Stengel, Benedicte, Powis, Stephen H, Brenchley, Paul, Feehally, John, Rees, Andrew J, Debiec, Hanna, Wetzels, Jack F M, Ronco, Pierre, Mathieson, Peter W, Kleta, Robert

“…Idiopathic membranous nephropathy is a major cause of the nephrotic syndrome in adults, but its etiologic basis is not fully understood. We investigated the…”
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Metatranscriptomic assessment of burn wound infection clearance by Ojala, Teija, Lindford, Andrew, Savijoki, Kirsi, Lagus, Heli, Tommila, Jenni, Medlar, Alan, Kuusela, Pentti, Varmanen, Pekka, Holm, Liisa, Vuola, Jyrki, Kankuri, Esko, Kankainen, Matti

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Robust multi-group gene set analysis with few replicates by Mishra, Pashupati P, Medlar, Alan, Holm, Liisa, Törönen, Petri

“…Competitive gene set analysis is a standard exploratory tool for gene expression data. Permutation-based competitive gene set analysis methods are preferable…”
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Séance: reference-based phylogenetic analysis for 18S rRNA studies by Medlar, Alan, Aivelo, Tuomas, Löytynoja, Ari

“…Marker gene studies often use short amplicons spanning one or more hypervariable regions from an rRNA gene to interrogate the community structure of uncultured…”
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Metabarcoding Gastrointestinal Nematodes in Sympatric Endemic and Nonendemic Species in Ranomafana National Park, Madagascar by Aivelo, Tuomas, Medlar, Alan, Löytynoja, Ari, Laakkonen, Juha, Jernvall, Jukka

“…Sympatric species are known to host the same parasites species. Nevertheless, surveys examining parasite assemblages in sympatric species are rare. To…”
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Tracking year-to-year changes in intestinal nematode communities of rufous mouse lemurs (Microcebus rufus) by Aivelo, Tuomas, Medlar, Alan, Löytynoja, Ari, Laakkonen, Juha, Jernvall, Jukka

“…While it is known that intestinal parasite communities vary in their composition over time, there is a lack of studies addressing how variation in component…”
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SwiftLink: parallel MCMC linkage analysis using multicore CPU and GPU by Medlar, Alan, Głowacka, Dorota, Stanescu, Horia, Bryson, Kevin, Kleta, Robert

“…Linkage analysis remains an important tool in elucidating the genetic component of disease and has become even more important with the advent of whole exome…”
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Risk HLA-DQA1 and PLA2R1 Alleles in Idiopathic Membranous Nephropathy by STANESCU, Horia C, ARCOS-BURGOS, Mauricio, STEPHENS, Henry A. F, LAUNDY, Valerie, PADMANABHAN, Sandosh, ZAWADZKA, Anna, HOFSTRA, Julia M, COENEN, Marieke J. H, DEN HEIJER, Martin, KIEMENEY, Lambertus A. L. M, BACQ-DAIAN, Delphine, STENGEL, Benedicte, MEDLAR, Alan, POWIS, Stephen H, BRENCHLEY, Paul, FEEHALLY, John, REES, AndrewJ, DEBIEC, Hanna, WETZELS, Jack F. M, RONCO, Pierre, MATHIESON, Peter W, KLETA, Robert, BOCKENHAUER, Detlef, KOTTGEN, Anna, DRAGOMIRESCU, Liviu, VOINESCU, Catalin, PATEL, Naina, PEARCE, Kerra, HUBANK, Mike

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