Search Results - "Mediouni, Sonia"

Forging a Functional Cure for HIV: Transcription Regulators and Inhibitors by Mediouni, Sonia, Lyu, Shuang, Schader, Susan M, Valente, Susana T

“…Current antiretroviral therapy (ART) increases the survival of HIV-infected individuals, yet it is not curative. The major barrier to finding a definitive cure…”
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Cell-Permeable Peptides Containing Cycloalanine Residues by Wu, Hao, Mousseau, Guillaume, Mediouni, Sonia, Valente, Susana T., Kodadek, Thomas

“…We present here an efficient alternative to N‐methylation for the purpose of morphing protein‐binding peptides into more serum‐stable and cell‐permeable…”
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Didehydro-Cortistatin A Inhibits HIV-1 by Specifically Binding to the Unstructured Basic Region of Tat by Mediouni, Sonia, Chinthalapudi, Krishna, Ekka, Mary K, Usui, Ippei, Jablonski, Joseph A, Clementz, Mark A, Mousseau, Guillaume, Nowak, Jason, Macherla, Venkat R, Beverage, Jacob N, Esquenazi, Eduardo, Baran, Phil, de Vera, Ian Mitchelle S, Kojetin, Douglas, Loret, Erwann P, Nettles, Kendall, Maiti, Souvik, Izard, Tina, Valente, Susana T

“…The intrinsically disordered HIV-1 Tat protein binds the viral RNA transactivation response structure (TAR), which recruits transcriptional cofactors,…”
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Resistance to the Tat Inhibitor Didehydro-Cortistatin A Is Mediated by Heightened Basal HIV-1 Transcription by Mousseau, Guillaume, Aneja, Rachna, Clementz, Mark A, Mediouni, Sonia, Lima, Noemia S, Haregot, Alexander, Kessing, Cari F, Jablonski, Joseph A, Thenin-Houssier, Suzie, Nagarsheth, Nisha, Trautmann, Lydie, Valente, Susana T

“…Human immunodeficiency virus type 1 (HIV-1) Tat binds the viral RNA structure transactivation-responsive element (TAR) and recruits transcriptional cofactors,…”
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Molecular motor protein KIF5C mediates structural plasticity and long-term memory by constraining local translation by Swarnkar, Supriya, Avchalumov, Yosef, Espadas, Isabel, Grinman, Eddie, Liu, Xin-an, Raveendra, Bindu L., Zucca, Aya, Mediouni, Sonia, Sadhu, Abhishek, Valente, Susana, Page, Damon, Miller, Kyle, Puthanveettil, Sathyanarayanan V.

“…Synaptic structural plasticity, key to long-term memory storage, requires translation of localized RNAs delivered by long-distance transport from the neuronal…”
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Next-Generation Human Cerebral Organoids as Powerful Tools To Advance NeuroHIV Research by Premeaux, Thomas A, Mediouni, Sonia, Leda, Ana, Furler, Robert L, Valente, Susana T, Fine, Howard A, Nixon, Douglas F, Ndhlovu, Lishomwa C

“…Long-term effective use of antiretroviral therapy (ART) among people with HIV (PWH) has significantly reduced the burden of disease, yet a cure for HIV has not…”
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Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture by Yuan, Zixuan, Pavel, Mahmud Arif, Wang, Hao, Kwachukwu, Jerome C., Mediouni, Sonia, Jablonski, Joseph Anthony, Nettles, Kendall W., Reddy, Chakravarthy B., Valente, Susana T., Hansen, Scott B.

“…Hydroxychloroquine (HCQ), a drug used to treat lupus and malaria, was proposed as a treatment for SARS-coronavirus-2 (SARS-CoV-2) infection, albeit with…”
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Didehydro-cortistatin A inhibits HIV-1 Tat mediated neuroinflammation and prevents potentiation of cocaine reward in Tat transgenic mice by Mediouni, Sonia, Jablonski, Joseph, Paris, Jason J, Clementz, Mark A, Thenin-Houssier, Suzie, McLaughlin, Jay P, Valente, Susana T

“…HIV-1 Tat protein has been shown to have a crucial role in HIV-1-associated neurocognitive disorders (HAND), which includes a group of syndromes ranging from…”
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Identification of potent small molecule inhibitors of SARS-CoV-2 entry by Mediouni, Sonia, Mou, Huihui, Otsuka, Yuka, Jablonski, Joseph Anthony, Adcock, Robert Scott, Batra, Lalit, Chung, Dong-Hoon, Rood, Christopher, de Vera, Ian Mitchelle S., Rahaim Jr, Ronald, Ullah, Sultan, Yu, Xuerong, Getmanenko, Yulia A., Kennedy, Nicole M., Wang, Chao, Nguyen, Tu-Trinh, Hull, Mitchell, Chen, Emily, Bannister, Thomas D., Baillargeon, Pierre, Scampavia, Louis, Farzan, Michael, Valente, Susana T., Spicer, Timothy P.

“…The severe acute respiratory syndrome coronavirus 2 responsible for COVID-19 remains a persistent threat to mankind, especially for the immunocompromised and…”
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Author Correction: Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture by Yuan, Zixuan, Pavel, Mahmud Arif, Wang, Hao, Kwachukwu, Jerome C., Mediouni, Sonia, Jablonski, Joseph Anthony, Nettles, Kendall W., Reddy, Chakravarthy B., Valente, Susana T., Hansen, Scott B.

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The role of high cholesterol in SARS-CoV-2 infectivity by Wang, Hao, Yuan, Zixuan, Pavel, Mahmud Arif, Jablonski, Sonia Mediouni, Jablonski, Joseph, Hobson, Robert, Valente, Susana, Reddy, Chakravarthy B., Hansen, Scott B.

“…Coronavirus disease 2019 (COVID-19) is a respiratory infection caused by severe acute respiratory syndrome coronavirus 2. The virus binds to angiotensinogen…”
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β-cyclodextrin polymer/Soluplus® encapsulated Ebselen ternary complex (EβpolySol) as a potential therapy for vaginal candidiasis and pre-exposure prophylactic for HIV by Vartak, Richa, Patki, Manali, Menon, Suvidha, Jablonski, Joseph, Mediouni, Sonia, Fu, Yige, Valente, Susana T., Billack, Blase, Patel, Ketan

“…[Display omitted] •β-cyclodextrin polymer showed 3–4 folds higher saturation solubility of Ebselen.•β-cyclodextrin polymer was safer on HeLa cells compared to…”
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Transcriptional regulation of the HIV-1 inhibitory factor human mannose receptor 1 by the myeloid-specific transcription factor PU.1 by Mallorson, Rosa, Miyagi, Eri, Kao, Sandra, Sukegawa, Sayaka, Saito, Hideki, Fabryova, Helena, Morellatto Ruggieri, Luciana, Mediouni, Sonia, Valente, Susana T, Strebel, Klaus

“…HIV-1 infection of cells results in the modulation of cellular gene expression by virus-encoded proteins in a manner that benefits the virus. We reported that…”
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Targeting HIV transcription: the quest for a functional cure by Mousseau, Guillaume, Mediouni, Sonia, Valente, Susana T

“…Antiretroviral therapy (ART) potently suppresses HIV-1 replication, but the virus persists in quiescent infected CD4(+)T cells as a latent integrated provirus,…”
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Efavirenz nanomicelles loaded vaginal film (EZ film) for preexposure prophylaxis (PrEP) of HIV by Patki, Manali, Vartak, Richa, Jablonski, Joseph, Mediouni, Sonia, Gandhi, Tasneem, Fu, Yige, Cetindag, Eylul, Dave, Rajesh, Valente, Susana T., Patel, Ketan

“…[Display omitted] •Efavirenz Vaginal film could be promising as Pre-exposure prophylaxis (PrEP) of HIV.•Tetronic 1107 showed better efavirenz solubility and…”
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Bictegravir nanomicelles and anionic pullulan loaded vaginal film: Dual mechanistic pre-exposure prophylaxis (PrEP) for HIV by Vartak, Richa, Jablonski, Joseph, Deore, Bhavesh, Mediouni, Sonia, Sanhueza, Carlos A., Valente, Susana T., Patel, Ketan

“…Locally delivered pre-exposure prophylaxis (PrEP) has proven to be a promising strategy to combat Human immunodeficiency virus (HIV) transmission but several…”
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The XPB Subunit of the TFIIH Complex Plays a Critical Role in HIV-1 Transcription and XPB Inhibition by Spironolactone Prevents HIV-1 Reactivation from Latency by Mori, Luisa, Jenike, Katharine, Yeh, Yang-Hui Jimmy, Lacombe, Benoît, Li, Chuan, Getzler, Adam, Mediouni, Sonia, Cameron, Michael, Pipkin, Matthew, Ho, Ya-Chi, Ramirez, Bertha Cecilia, Valente, Susana

“…HIV transcription requires assembly of cellular transcription factors at the HIV-1promoter. The TFIIH general transcription factor facilitates transcription…”
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The Tat inhibitor didehydro‐cortistatin A suppresses SIV replication and reactivation by Mediouni, Sonia, Kessing, Cari F., Jablonski, Joseph A., Thenin-Houssier, Suzie, Clementz, Mark, Kovach, Melia D., Mousseau, Guillaume, De Vera, Ian Mitchelle S., Li, Chuan, Kojetin, Douglas J., Evans, David T., Valente, Susana T.

“…ABSTRACT The HIV‐1 transactivation protein (Tat) binds the HIV mRNA transactivation responsive element (TAR), regulating transcription and reactivation from…”
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The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders by Mediouni, Sonia, Marcondes, Maria Cecilia Garibaldi, Miller, Courtney, McLaughlin, Jay P, Valente, Susana T

“…Antiretroviral therapy has dramatically improved the lives of human immunodeficiency virus 1 (HIV-1) infected individuals. Nonetheless, HIV-associated…”
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Identification of a Highly Conserved Surface on Tat Variants by Mediouni, Sonia, Darque, Albert, Ravaux, Isabelle, Baillat, Gilbert, Devaux, Christian, Loret, Erwann P.

“…Extracellular Tat is suspected to protect HIV-1-infected cells from cellular immunity. Seropositive patients are unable to produce neutralizing antibodies…”
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