Anti‐inflammatory and antinociceptive effects of tilifodiolide, isolated from Salvia tiliifolia Vahl (Lamiaceae)

Anti‐inflammatory and antinociceptive effects of tilifodiolide, isolated from Salvia tiliifolia Vahl (Lamiaceae)

Salvia tiliifolia Vahl (Lamiaceae) is used for the empirical treatment of pain and inflammation. The diterpenoid tilifodiolide (TFD) was isolated from Salvia tiliifolia. The in vitro anti‐inflammatory effects of TFD (0.1–200 µM) were assessed using murine macrophages stimulated with LPS and estimati...

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Published in:Drug development research Vol. 79; no. 4; pp. 165 - 172
Main Authors: González‐Chávez, Marco Martin, Alonso‐Castro, Angel Josabad, Zapata‐Morales, Juan Ramón, Arana‐Argáez, Víctor, Torres‐Romero, Julio Cesar, Medina‐Rivera, Yessica Elisa, Sánchez‐Mendoza, Ernesto, Pérez‐Gutiérrez, Salud
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01-06-2018
Subjects:
Acetic acid
Analgesics - pharmacology
Animals
Anti-Inflammatory Agents - pharmacology
antinociceptive
anti‐inflammatory
Carrageenan
Dose-Response Relationship, Drug
Edema
Field tests
Formaldehyde
In vivo methods and tests
Indomethacin
Indomethacin - pharmacology
Inflammation
Interleukin-6 - metabolism
Lamiaceae
Lipopolysaccharides
Locomotor activity
Macrophages
Macrophages - metabolism
Male
Mice
Motor Activity
Naloxone
Naloxone - pharmacology
Naproxen
Naproxen - pharmacology
Open-field behavior
Pain
Pain Measurement - drug effects
Pain perception
Rodents
Rotarod Performance Test
Salvia - chemistry
Salvia tiliifolia
tilifodiolide
Tumor necrosis factor
Tumor Necrosis Factor-alpha - metabolism
anti-inflammatory
antinociceptive
tilifodiolide
Salvia tiliifolia
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Summary:Salvia tiliifolia Vahl (Lamiaceae) is used for the empirical treatment of pain and inflammation. The diterpenoid tilifodiolide (TFD) was isolated from Salvia tiliifolia. The in vitro anti‐inflammatory effects of TFD (0.1–200 µM) were assessed using murine macrophages stimulated with LPS and estimating the levels of pro‐inflammatory mediators for 48 h. The in vivo anti‐inflammatory activity of TFD was assessed using the carrageenan‐induced paw edema test for 6 h. The antinociceptive effects of TFD were evaluated using the formalin test and the acetic acid induced‐writhing test. The effects of TFD on locomotor activity were assessed using the open field test and the rotarod test. TFD inhibited the production of TNF‐α (IC50 = 5.66 µM) and IL‐6 (IC50 = 1.21 µM) in macrophages. TFD (200 mg/kg) showed anti‐inflammatory effects with similar activity compared to 10 mg/kg indomethacin. The administration of TFD induced antinociception in the phase 1 (ED50 = 48.2 mg/kg) and the phase 2 (ED50 = 28.9 mg/kg) of the formalin test. In the acetic acid assay, TFD showed antinociceptive effects (ED50 = 32.3 mg/kg) with similar potency compared to naproxen (ED50 = 36.2 mg/kg). In the presence of different inhibitors in the acetic acid assay, only the co‐administration of TFD and naloxone reverted the antinociceptive activity shown by TFD alone. TFD did not affect locomotor activity in mice. TFD exerts in vitro and in vivo anti‐inflammatory activity and in vivo antinociceptive effects.
Bibliography:Funding information
Universidad de Guanajuato, Grant/Award number: DAIP, CIIC 31/2018; Consejo Nacional de Ciencia y Tecnologia, Grant/Award number: CB‐2015‐01‐257872
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0272-4391
1098-2299
DOI:10.1002/ddr.21432