Search Results - "Medina, Sarah J."

Leapfrog dynamics in phage‐bacteria coevolution revealed by joint analysis of cross‐infection phenotypes and whole genome sequencing by Gupta, Animesh, Peng, Shengyun, Leung, Chung Yin, Borin, Joshua M., Medina, Sarah J., Weitz, Joshua S., Meyer, Justin R., Ben‐Ami, Frida

“…Viruses and their hosts can undergo coevolutionary arms races where hosts evolve increased resistance and viruses evolve counter‐resistance. Given these arms…”
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Competition-driven eco-evolutionary feedback reshapes bacteriophage lambda’s fitness landscape and enables speciation by Doud, Michael B., Gupta, Animesh, Li, Victor, Medina, Sarah J., De La Fuente, Caesar A., Meyer, Justin R.

“…A major challenge in evolutionary biology is explaining how populations navigate rugged fitness landscapes without getting trapped on local optima. One idea…”
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Downregulation of circulating miR 802‐5p and miR 194‐5p and upregulation of brain MEF2C along breast cancer brain metastasization by Sereno, Marta, Haskó, János, Molnár, Kinga, Medina, Sarah J., Reisz, Zita, Malhó, Rui, Videira, Mafalda, Tiszlavicz, László, Booth, Stephanie A., Wilhelm, Imola, Krizbai, István A., Brito, Maria Alexandra

“…Breast cancer brain metastases (BCBMs) have been underinvestigated despite their high incidence and poor outcome. MicroRNAs (miRNAs), and particularly…”
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Neurons and Astrocytes Elicit Brain Region Specific Transcriptional Responses to Prion Disease in the Murine CA1 and Thalamus by Slota, Jessy A, Medina, Sarah J, Frost, Kathy L, Booth, Stephanie A

“…Progressive dysfunction and loss of neurons ultimately culminates in the symptoms and eventual fatality of prion disease, yet the pathways and mechanisms that…”
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Differentiated cultures of an immortalized human neural progenitor cell line do not replicate prions despite PrPC overexpression by Slota, Jessy A., Wang, Xinzhu, Lusansky, Diana, Medina, Sarah J., Booth, Stephanie A.

“…Prions are misfolded proteins that accumulate within the brain in association with a rare group of fatal and infectious neurological disorders in humans and…”
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The cell type resolved mouse transcriptome in neuron-enriched brain tissues from the hippocampus and cerebellum during prion disease by Majer, Anna, Medina, Sarah J., Sorensen, Debra, Martin, Matthew J., Frost, Kathy L., Phillipson, Clark, Manguiat, Kathy, Booth, Stephanie A.

“…Multiple cell types and complex connection networks are an intrinsic feature of brain tissue. In this study we used expression profiling of specific…”
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Early mechanisms of pathobiology are revealed by transcriptional temporal dynamics in hippocampal CA1 neurons of prion infected mice by Majer, Anna, Medina, Sarah J, Niu, Yulian, Abrenica, Bernard, Manguiat, Kathy J, Frost, Kathy L, Philipson, Clark S, Sorensen, Debra L, Booth, Stephanie A

“…Prion diseases typically have long pre-clinical incubation periods during which time the infectious prion particle and infectivity steadily propagate in the…”
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Identification of circulating microRNA signatures as potential biomarkers in the serum of elk infected with chronic wasting disease by Slota, Jessy A., Medina, Sarah J., Klassen, Megan, Gorski, Damian, Mesa, Christine M., Robertson, Catherine, Mitchell, Gordon, Coulthart, Michael B., Pritzkow, Sandra, Soto, Claudio, Booth, Stephanie A.

“…Chronic wasting disease (CWD) is an emerging infectious prion disorder that is spreading rapidly in wild populations of cervids in North America. The risk of…”
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MicroRNA and mRNA Dysregulation in Astrocytes Infected with Zika Virus by Kozak, Robert A, Majer, Anna, Biondi, Mia J, Medina, Sarah J, Goneau, Lee W, Sajesh, Babu V, Slota, Jessy A, Zubach, Vanessa, Severini, Alberto, Safronetz, David, Hiebert, Shannon L, Beniac, Daniel R, Booth, Timothy F, Booth, Stephanie A, Kobinger, Gary P

“…The Zika virus (ZIKV) epidemic is an ongoing public health concern. ZIKV is a flavivirus reported to be associated with microcephaly, and recent work in animal…”
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A Novel Triple-Mutant AAV6 Capsid Induces Rapid and Potent Transgene Expression in the Muscle and Respiratory Tract of Mice by van Lieshout, Laura P, Domm, Jakob M, Rindler, Tara N, Frost, Kathy L, Sorensen, Debra L, Medina, Sarah J, Booth, Stephanie A, Bridges, James P, Wootton, Sarah K

“…Gene therapy for the treatment of genetic disorders has demonstrated considerable therapeutic success in clinical trials. Among the most effective and commonly…”
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Dysregulation of neuroprotective astrocytes, a spectrum of microglial activation states, and altered hippocampal neurogenesis are revealed by single-cell RNA sequencing in prion disease by Slota, Jessy A, Sajesh, Babu V, Frost, Kathy F, Medina, Sarah J, Booth, Stephanie A

“…Prion diseases are neurodegenerative disorders with long asymptomatic incubation periods, followed by a rapid progression of cognitive and functional decline…”
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Dual RNA-Seq characterization of host and pathogen gene expression in liver cells infected with Crimean-Congo Hemorrhagic Fever Virus by Kozak, Robert A, Fraser, Russell S, Biondi, Mia J, Majer, Anna, Medina, Sarah J, Griffin, Bryan D, Kobasa, Darwyn, Stapleton, Patrick J, Urfano, Chantel, Babuadze, Giorgi, Antonation, Kym, Fernando, Lisa, Booth, Stephanie, Lillie, Brandon N, Kobinger, Gary P

“…Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus that can cause a hemorrhagic fever in humans, with a case fatality rate of up to 40%. Cases…”
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Non-Productive Infection of Glial Cells with SARS-CoV-2 in Hamster Organotypic Cerebellar Slice Cultures by Lamoureux, Lise, Sajesh, Babu, Slota, Jessy A., Medina, Sarah J., Mayor, Matthew, Frost, Kathy L., Warner, Bryce, Manguiat, Kathy, Wood, Heidi, Kobasa, Darwyn, Booth, Stephanie A.

“…The numerous neurological syndromes associated with COVID-19 implicate an effect of viral pathogenesis on neuronal function, yet reports of direct SARS-CoV-2…”
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Ecological speciation of bacteriophage lambda in allopatry and sympatry by Meyer, Justin R., Dobias, Devin T., Medina, Sarah J., Servilio, Lisa, Gupta, Animesh, Lenski, Richard E.

“…Understanding the conditions that allow speciation to occur is difficult because most research has focused on either long-lived organisms or asexual…”
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Destabilizing mutations encode nongenetic variation that drives evolutionary innovation by Petrie, Katherine L, Palmer, Nathan D, Johnson, Daniel T, Medina, Sarah J, Yan, Stephanie J, Li, Victor, Burmeister, Alita R, Meyer, Justin R

“…Evolutionary innovations are often achieved by repurposing existing genes to perform new functions; however, the mechanisms enabling the transition from old to…”
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Bacteriophage lambda overcomes a perturbation in its host–viral genetic network through mutualism and evolution of life history traits by Gupta, Animesh, Soto, Anechelle N., Medina, Sarah J., Petrie, Katherine L., Meyer, Justin R.

“…An important driver of evolution in viruses is natural selection to optimize the use of their hosts’ genetic network. To learn how viruses respond to this…”
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Differentiated cultures of an immortalized human neural progenitor cell line do not replicate prions despite PrP C overexpression by Slota, Jessy A, Wang, Xinzhu, Lusansky, Diana, Medina, Sarah J, Booth, Stephanie A

“…Prions are misfolded proteins that accumulate within the brain in association with a rare group of fatal and infectious neurological disorders in humans and…”
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A Functional SNP Catalog of Overlapping miRNA-Binding Sites in Genes Implicated in Prion Disease and Other Neurodegenerative Disorders by Saba, Reuben, Medina, Sarah J., Booth, Stephanie A.

“…ABSTRACT The involvement of SNPs in miRNA target sites remains poorly investigated in neurodegenerative disease. In addition to associations with disease risk,…”
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Enhancement of in vitro and in vivo microdialysis recovery of SB-265123 using Intralipid® and Encapsin® as perfusates by Ward, Keith W., Medina, Sarah J., Portelli, Samm T., Mahar Doan, Kelly M., Spengler, Michael D., Ben, Michael M., Lundberg, David, Levy, Mark A., Chen, Emile P.

“…This study was conducted to compare the ability of two potential microdialysis perfusates to enhance the recovery of SB‐265123, a lipophilic, highly…”
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