Search Results - "Medina, Rodolfo A."

Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: Ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues by Godoy, Alejandro, Ulloa, Viviana, Rodríguez, Federico, Reinicke, Karin, Yañez, Alejandro J., García, María de los Angeles, Medina, Rodolfo A., Carrasco, Mónica, Barberis, Sofía, Castro, Tamara, Martínez, Fernando, Koch, Ximena, Vera, Juan Carlos, Poblete, María Teresa, Figueroa, Carlos D., Peruzzo, Bruno, Pérez, Fernando, Nualart, Francisco

“…It has been proposed that the enhanced metabolic activity of tumor cells is accompanied by an increased expression of facilitative hexose transporters (GLUTs)…”
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Glucose transporters: expression, regulation and cancer by Medina, Rodolfo A, Owen, Gareth I

“…Mammalian cells depend on glucose as a major substrate for energy production. Glucose is transported into the cell via facilitative glucose transporters (GLUT)…”
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Estrogen and Progesterone Up-Regulate Glucose Transporter Expression in ZR-75-1 Human Breast Cancer Cells by Medina, Rodolfo A, Meneses, Ana Maria, Vera, Juan Carlos, Guzman, Catherine, Nualart, Francisco, Astuya, Allisson, de los Angeles García, María, Kato, Sumie, Carvajal, Andrés, Pinto, Mauricio, Owen, Gareth I

“…Breast cancer incidence increases in women receiving combined estrogen and progesterone therapy. Breast tumors show increased expression of the glucose…”
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64Cu-CTS: A Promising Radiopharmaceutical for the Identification of Low-Grade Cardiac Hypoxia by PET by Medina, Rodolfo A, Mariotti, Erika, Pavlovic, Davor, Shaw, Karen P, Eykyn, Thomas R, Blower, Philip J, Southworth, Richard

“…The subtle hypoxia underlying chronic cardiovascular disease is an attractive target for PET imaging, but the lead hypoxia imaging agents…”
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Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation by BRENNAN, Jonathan P, SOUTHWORTH, Richard, MEDINA, Rodolfo A, DAVIDSON, Sean M, DUCHEN, Michael R, SHATTOCK, Michael J

“…Both K(ATP) channel opening drugs and ischaemic preconditioning have been suggested to protect the ischaemic heart by acting on K(ATP) channels in the inner…”
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Insulin regulates GLUT1-mediated glucose transport in MG-63 human osteosarcoma cells by Cifuentes, Manuel, García, Maria A., Arrabal, Pilar M., Martínez, Fernando, Yañez, María J., Jara, Nery, Weil, Bernardo, Domínguez, Dolores, Medina, Rodolfo A., Nualart, Francisco

“…Osteosarcoma is the most common type of malignant bone cancer, accounting for 35% of primary bone malignancies. Because cancer cells utilize glucose as their…”
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The action of ovarian hormones in cardiovascular disease by Medina, Rodolfo A, Aranda, Evelyn, Verdugo, Cesar, Kato, Sumie, Owen, Gareth I

“…The incidence of cardiovascular disease (CAD) differs between men and women, in part because of differences in risk factors and hormones. This sexual…”
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Trapped Platelets Activated in Ischemia Initiate Ventricular Fibrillation by Dhanjal, Tarvinder S, Medina, Rodolfo A, Leem, Jinwoo, Clark, James E, Southworth, Richard, Curtis, Michael J

“…BACKGROUND—We tested the hypothesis that ischemia-induced ventricular fibrillation (VF) is facilitated by platelets, trapped regionally in the ischemic zone…”
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Demonstration of the retention of 64Cu-ATSM in cardiac myocytes using a novel incubation chamber for screening hypoxia-dependent radiotracers by Handley, Maxwell G., Medina, Rodolfo A., Paul, Rowena L., Blower, Philip J., Southworth, Richard

“…OBJECTIVEWe have designed a low-cost, reusable incubation system that allows cells to be cultured in either plated or suspension culture under complete…”
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Cardiac hypoxia imaging: second-generation analogues of 64Cu-ATSM by Handley, Maxwell G, Medina, Rodolfo A, Mariotti, Erika, Kenny, Gavin D, Shaw, Karen P, Yan, Ran, Eykyn, Thomas R, Blower, Philip J, Southworth, Richard

“…Myocardial hypoxia is an attractive target for diagnostic and prognostic imaging, but current approaches are insufficiently sensitive for clinical use. The PET…”
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Regulation of GLUT3 and glucose uptake by the cAMP signalling pathway in the breast cancer cell line ZR-75 by Meneses, Ana Maria, Medina, Rodolfo A., Kato, Sumie, Pinto, Mauricio, Jaque, Maria Paz, Lizama, Isabel, García, María de los Ángeles, Nualart, Francisco, Owen, Gareth I.

“…Increased glucose uptake as a principal energy source is a requirement for the continued survival of tumour cells. Facilitative glucose transporter‐1 (GLUT1)…”
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Apical and basolateral localisation of GLUT2 transporters in human lung epithelial cells by Kalsi, Kameljit K., Baker, Emma H., Medina, Rodolfo A., Rice, Suman, Wood, David M., Ratoff, Jonathan C., Philips, Barbara J., Baines, Deborah L.

“…Glucose concentrations of normal human airway surface liquid are ~12.5 times lower than blood glucose concentrations indicating that glucose uptake by…”
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Assessing radiotracer kinetics in the Langendorff perfused heart by Mariotti, Erika, Veronese, Mattia, Dunn, Joel T, Medina, Rodolfo A, Blower, Philip J, Southworth, Richard, Eykyn, Thomas R

“…Background The Langendorff perfused heart is a physiologically relevant and controllable model with potential for assessing the pharmacokinetics of new…”
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Glucose transporters in sex steroid hormone related cancer by Nualart, Francisco, Los Angeles García, Maríade, Medina, Rodolfo A, Owen, Gareth I

“…Cancer cells, as with most mammalian cells, depend on a continuous supply of glucose; not only as a precursor of glycoproteins, triglycerides and glycogen, but…”
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Developing Hyperpolarized 13C Spectroscopy and Imaging for Metabolic Studies in the Isolated Perfused Rat Heart by Weiss, Kilian, Mariotti, Erika, Hill, Deborah K., Orton, Matthew R., Dunn, Joel T., Medina, Rodolfo A., Southworth, Richard, Kozerke, Sebastian, Eykyn, Thomas R.

“…Hyperpolarized 13 C magnetic resonance is a powerful tool for the study of cardiac metabolism. In this work, we have implemented protocols for the real-time…”
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Differential regulation of glucose transporter expression by estrogen and progesterone in Ishikawa endometrial cancer cells by Medina, RA, Meneses, AM, Vera, JC, Guzman, C, Nualart, F, Rodriguez, F, de los Angeles Garcia, M, Kato, S, Espinoza, N, Monso, C, Carvajal, A, Pinto, M, Owen, GI

“…Estrogen replacement therapy and other unopposed estrogen treatments increase the incidence of endometrial abnormalities, including cancer. However, this…”
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Lactate-induced translocation of GLUT1 and GLUT4 is not mediated by the phosphatidyl-inositol-3-kinase pathway in the rat heart by Medina, Rodolfo A, Southworth, Richard, Fuller, William, Garlick, Pamela B

“…We have determined the effect of lactate on the translocation of GLUT1 and GLUT4 and on the myocardial uptake and phosphorylation of the glucose analogues…”
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Differential Centrifugation Separates Cardiac Sarcolemmal and Endosomal Membranes from Langendorff-Perfused Rat Hearts by Fuller, William, Eaton, Philip, Medina, Rodolfo A., Bell, James, Shattock, Michael J.

“…The application of subcellular fractionation protocols developed in soft tissues to fibrous organs such as the heart is unsuitable given the substantial…”
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Lactate-induced translocation of GLUT1 and GLUT4 is not mediated by the phosphatidylinositol-3-kinase pathway in the rat heart by Medina, Rodolfo A., Southworth, Richard, Fuller, William, Garlick, Pamela B.

“…We have determined the effect of lactate on the translocation of GLUT1 and GLUT4 and on the myocardial uptake and phosphorylation of the glucose analogues…”
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2-Methoxyestradiol and Disorders of Female Reproductive Tissues by Pinto, Mauricio P., Medina, Rodolfo A., Owen, Gareth I.

“…2-Methoxyestradiol (2ME) is an endogenous metabolite of 17β-estradiol. Once thought of as a mere degradation product, 2ME has gained attention as an important…”
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