Search Results - "Medina, L."

Movement velocity as a measure of loading intensity in resistance training by González-Badillo, J J, Sánchez-Medina, L

“…This study examined the possibility of using movement velocity as an indicator of relative load in the bench press (BP) exercise. One hundred and twenty…”
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The rapidly evolving view of lysosomal storage diseases by Parenti, Giancarlo, Medina, Diego L, Ballabio, Andrea

“…Lysosomal storage diseases are a group of metabolic disorders caused by deficiencies of several components of lysosomal function. Most commonly affected are…”
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Effects of velocity loss during resistance training on athletic performance, strength gains and muscle adaptations by Pareja‐Blanco, F., Rodríguez‐Rosell, D., Sánchez‐Medina, L., Sanchis‐Moysi, J., Dorado, C., Mora‐Custodio, R., Yáñez‐García, J. M., Morales‐Alamo, D., Pérez‐Suárez, I., Calbet, J. A. L., González‐Badillo, J. J.

“…We compared the effects of two resistance training (RT) programs only differing in the repetition velocity loss allowed in each set: 20% (VL20) vs 40% (VL40)…”
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Velocity- and power-load relationships of the bench pull vs. bench press exercises by Sánchez-Medina, L, González-Badillo, J J, Pérez, C E, Pallarés, J G

“…This study compared the velocity- and power-load relationships of the antagonistic upper-body exercises of prone bench pull (PBP) and bench press (BP). 75…”
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Phase formation in magnetron sputtered CrMnFeCoNi high entropy alloy by Zendejas Medina, L., Riekehr, L., Jansson, U.

“…Thin films of the CrMnFeCoNi high entropy alloy were deposited by magnetron sputtering from a sintered equimolar target. The substrate temperature and bias…”
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Adjunctive Rifampicin Increases Antibiotic Efficacy in Group A Streptococcal Tissue Infection Models by Bergsten, H, Palma Medina, L M, Morgan, M, Moll, K, Skutlaberg, D H, Skrede, S, Wajima, T, Svensson, M, Norrby-Teglund, A

“…Biofilm has recently been highlighted as a complicating feature of necrotizing soft tissue infections (NSTI) caused by Streptococcus pyogenes (i.e., group A…”
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Flt3 Signaling in B Lymphocyte Development and Humoral Immunity by Medina, Kay L.

“…The Class III receptor tyrosine kinase Flt3 and its ligand, the Flt3-ligand (FL), play an integral role in regulating the proliferation, differentiation, and…”
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Recognizing Pitfalls in Virtual Screening: A Critical Review by Scior, Thomas, Bender, Andreas, Tresadern, Gary, Medina-Franco, José L, Martínez-Mayorga, Karina, Langer, Thierry, Cuanalo-Contreras, Karina, Agrafiotis, Dimitris K

“…The aim of virtual screening (VS) is to identify bioactive compounds through computational means, by employing knowledge about the protein target…”
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Effect of movement velocity during resistance training on neuromuscular performance by Pareja-Blanco, F, Rodríguez-Rosell, D, Sánchez-Medina, L, Gorostiaga, E M, González-Badillo, J J

“…This study aimed to compare the effect on neuromuscular performance of 2 isoinertial resistance training programs that differed only in actual repetition…”
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Extended connectivity interaction features: improving binding affinity prediction through chemical description by Sánchez-Cruz, Norberto, Medina-Franco, José L, Mestres, Jordi, Barril, Xavier

“…Abstract Motivation Machine-learning scoring functions (SFs) have been found to outperform standard SFs for binding affinity prediction of protein–ligand…”
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Editorial: In silico Methods for Drug Design and Discovery by Brogi, Simone, Ramalho, Teodorico Castro, Kuca, Kamil, Medina-Franco, José L., Valko, Marian

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Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance by Medina, Diego L., Fraldi, Alessandro, Bouche, Valentina, Annunziata, Fabio, Mansueto, Gelsomina, Spampanato, Carmine, Puri, Claudia, Pignata, Antonella, Martina, Jose A., Sardiello, Marco, Palmieri, Michela, Polishchuk, Roman, Puertollano, Rosa, Ballabio, Andrea

“…Lysosomes are cellular organelles primarily involved in degradation and recycling processes. During lysosomal exocytosis, a Ca2+-regulated process, lysosomes…”
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Vibrations inside buildings due to subway railway traffic. Experimental validation of a comprehensive prediction model by Lopes, Patrícia, Ruiz, Jésus Fernández, Alves Costa, Pedro, Medina Rodríguez, L., Cardoso, António Silva

“…The present paper focuses on the experimental validation of a numerical approach previously proposed by the authors for the prediction of vibrations inside…”
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Shifting from the single to the multitarget paradigm in drug discovery by Medina-Franco, José L., Giulianotti, Marc A., Welmaker, Gregory S., Houghten, Richard A.

“…[Display omitted] ► Drug discovery is changing from a one target–one drug to a multiple-target model. ► Drug repurposing is a positive application of…”
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Yes SIR! On the structure–inactivity relationships in drug discovery by López-López, Edgar, Fernández-de Gortari, Eli, Medina-Franco, José L.

“…•Inactivity data is helpful.•Structure-Inactivity Relationships (SIRs) are valuable in drug discovery.•Machine and deep learning benefit from SIRs.•The…”
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Increased risk of non-AIDS-related events in HIV subjects with persistent low CD4 counts despite cART in the CoRIS cohort by Pacheco, Y.M., Jarrin, I., Rosado, I., Campins, A.A., Berenguer, J., Iribarren, J.A., Rivero, M., Muñoz-Medina, L., Bernal-Morell, E., Gutiérrez, F., Leal, M.

“…•We explored clinical complications of HIV subjects with persistent low CD4 despite virological suppression under cART.•The persistence of low CD4 despite…”
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Clinical challenges and future therapeutic approaches for neuronal ceroid lipofuscinosis by Mole, Sara E, Anderson, Glenn, Band, Heather A, Berkovic, Samuel F, Cooper, Jonathan D, Kleine Holthaus, Sophia-Martha, McKay, Tristan R, Medina, Diego L, Rahim, Ahad A, Schulz, Angela, Smith, Alexander J

“…Treatment of the neuronal ceroid lipofuscinoses, also known as Batten disease, is at the start of a new era because of diagnostic and therapeutic advances…”
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TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway by Scotto Rosato, A., Montefusco, S., Soldati, C., Di Paola, S., Capuozzo, A., Monfregola, J., Polishchuk, E., Amabile, A., Grimm, C., Lombardo, A., De Matteis, M. A., Ballabio, A., Medina, D. L.

“…The lysosomal calcium channel TRPML1, whose mutations cause the lysosomal storage disorder (LSD) mucolipidosis type IV (MLIV), contributes to upregulate…”
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In Silico ADME/Tox Profiling of Natural Products: A Focus on BIOFACQUIM by Durán-Iturbide, Noemi Angeles, Díaz-Eufracio, Bárbara I, Medina-Franco, José L

“…Natural products continue to be major sources of bioactive compounds and drug candidates not only because of their unique chemical structures but also because…”
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Importance of the propulsive phase in strength assessment by Sanchez-Medina, L, Perez, C E, Gonzalez-Badillo, J J

“…This study analyzed the contribution of the propulsive and braking phases among different percentages of the one-repetition maximum (1RM) in the concentric…”
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