Search Results - "Medin, J A"

Lentivirus IL‐10 Gene Therapy Down‐Regulates IL‐17 and Attenuates Mouse Orthotopic Lung Allograft Rejection by Hirayama, S., Sato, M., Loisel‐Meyer, S., Matsuda, Y., Oishi, H., Guan, Z., Saito, T., Yeung, J., Cypel, M., Hwang, D. M., Medin, J. A., Liu, M., Keshavjee, S.

“…The purpose of the study was to examine the effect of lentivirus‐mediated IL‐10 gene therapy to target lung allograft rejection in a mouse orthotopic left lung…”
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Sphingolipid pathway enzymes modulate cell fate and immune responses by Molino, Tate, McKillop, WM, Medin, JA

“…Sphingolipids (SLs) are a class of essential, bioactive lipids. The SL family includes over 4000 distinct molecules, characterized by their sphingoid base…”
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Efficient correction of Fabry mice and patient cells mediated by lentiviral transduction of hematopoietic stem progenitor cells by YOSHIMITSU, M, HIGUCHI, K, RAMSUBIR, S, NONAKA, T, RASAIAH, V. I, SIATSKAS, C, LIANG, S.-B, MURRAY, G. J, BRADY, R. O, MEDIN, J. A

“…A deficiency in alpha-galactosidase A (alpha-gal A) activity causes Fabry disease. Virus-based delivery of genes can correct cells and establish a sustained…”
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Differential immune responses mediated by adenovirus- and lentivirus-transduced DCs in a HER-2 neu overexpressing tumor model by Felizardo, T C, Wang, J C M, McGray, R A J, Evelegh, C, Spaner, D E, Fowler, D H, Bramson, J L, Medin, J A

“…Recent investigations have demonstrated that adenoviral and lentiviral vectors encoding HER-2 can be utilized in cancer immunotherapy. However, it is not known…”
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Transduction and Transplantation of Spermatogonia into the Testis of Ram Lambs through the Extra-testicular Rete by Rodriguez-Sosa, JR, Silvertown, JD, Foster, RA, Medin, JA, Hahnel, A

“…Spermatogonial transplantation will provide a new way to study spermatogenesis in domestic animals, disseminate male genetics and produce transgenic animals,…”
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Gene therapy for Fabry disease by Sitaskas, C., Medin, J. A.

“…Fabry disease is an X‐linked metabolic disorder caused by a deficiency ofα‐galactosidase A (α‐Gal A). Lack of this lysosomal hydrolase results in…”
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Novel application of lentiviral vectors towards treatment of graft-versus-host disease by Scaife, Matthew D, Neschadim, Anton, Fowler, D H, Medin, J A

“…Allogeneic transplantation of hematopoietic stem cells and lymphocytes is a curative treatment for malignant and non-malignant disease. However, the primary…”
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Retrovirally transduced murine T lymphocytes expressing FasL mediate effective killing of prostate cancer cells by Symes, J C, Siatskas, C, Fowler, D H, Medin, J A

“…Adoptively transferred T cells possess anticancer activities partially mediated by T-cell FasL engagement of Fas tumor targets. However, antigen-induced T-cell…”
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Bystander killing of malignant cells via the delivery of engineered thymidine-active deoxycytidine kinase for suicide gene therapy of cancer by Neschadim, A, Wang, J C M, Lavie, A, Medin, J A

“…Activity and specificity of chemotherapeutic agents against solid tumors can be augmented via the targeted or localized delivery of ‘suicide’ genes. Selective…”
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Engineered human Tmpk fused with truncated cell-surface markers: versatile cell-fate control safety cassettes by Scaife, M, Pacienza, N, Au, B C Y, Wang, J C M, Devine, S, Scheid, E, Lee, C-J, Lopez-Perez, O, Neschadim, A, Fowler, D H, Foley, R, Medin, J A

“…Cell-fate control gene therapy (CFCGT)-based strategies can augment existing gene therapy and cell transplantation approaches by providing a safety element in…”
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Molecular Interactions Between Interferon Consensus Sequence Binding Protein and Members of the Interferon Regulatory Factor Family by Bovolenta, Chiara, Driggers, Paul H., Marks, Michael S., Medin, Jeffrey A., Politis, Alexander D., Vogel, Stefanie N., Levy, David E., Sakaguchi, Kazuyasu, Appella, Ettore, Coligan, John E., Ozato, Keiko

“…Interferon (IFN) consensus sequence binding protein (ICSBP) is a transcription factor expressed mostly in the cells of the immune system. ICSBP belongs to the…”
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Retinoic acid induction of major histocompatibility complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-kappa B (p50-p65) and retinoic acid receptor beta-retinoid X receptor beta heterodimers by SEGARS, J. H, NAGATA, T, STEPHANY, D. A, NEEL, B, SIEBENLIST, U, OZATO, K, BOURS, V, MEDIN, J. A, FRANZOSO, G, BLANCO, J. C. G, DREW, P. D, BECKER, K. G, JIABIN AN, TANG, T

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Circulating alpha-galactosidase A derived from transduced bone marrow cells: relevance for corrective gene transfer for Fabry disease by Takenaka, T, Qin, G, Brady, R O, Medin, J A

“…Fabry disease is caused by a deficiency of the lysosomal enzyme alpha-galactosidase A (alpha-gal A). We previously engineered a retrovirus encoding human…”
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Correction in Trans for Fabry Disease: Expression, Secretion, and Uptake of α -Galactosidase A in Patient-Derived Cells Driven by a High-Titer Recombinant Retroviral Vector by Medin, Jeffrey A., Tudor, Matthew, Simovitch, Ryan, Quirk, Jane M., Jacobson, Steven, Murray, Gary J., Brady, Roscoe O.

“…Fabry disease is an X-linked metabolic disorder due to a deficiency of α -galactosidase A (α -gal A; EC 3.2.1.22). Patients accumulate glycosphingolipids with…”
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Efficient, Low-Cost Protein Factories: Expression of Human Adenosine Deaminase in Baculovirus-Infected Insect Larvae by Medin, Jeffrey A., Hunt, Laura, Gathy, Karen, Evans, Robert K., Coleman, Mary Sue

“…Human adenosine deaminase (EC 3.5.4.4), a key purine salvage enzyme essential for immune competence, has been overproduced in Spodoptera frugiperda cells and…”
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Retrovirus-mediated correction of the metabolic defect in cultured Farber disease cells by Medin, J A, Takenaka, T, Carpentier, S, Garcia, V, Basile, J P, Segui, B, Andrieu-Abadie, N, Auge, N, Salvayre, R, Levade, T

“…Farber disease is a rare severe lysosomal storage disorder due to a deficient activity of the enzyme acid ceramidase (AC). Patients have granulomas along with…”
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Selection of Transduced CD34+Progenitors and Enzymatic Correction of Cells from Gaucher Patients, with Bicistronic Vectors by Migita, M, Medin, J A, Pawliuk, R, Jacobson, S, Nagle, J W, Anderson, S, Amiri, M, Humphries, R K, Karlsson, S

“…The gene transfer efficiency of human hematopoietic stem cells is still inadequate for efficient gene therapy of most disorders. To overcome this problem, a…”
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Recombinant Thyroid Hormone Receptor and Retinoid X Receptor Stimulate Ligand-Dependent Transcription in vitro by Lee, Insong J., Driggers, Paul H., Medin, Jeffrey A., Nikodem, Vera M., Ozato, Keiko

“…The thyroid hormone and retinoid X receptors form a heterodimer with each other and mediate thyroid hormone (T3)-dependent transcription. Retinoid X receptor,…”
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Viral vectors for gene therapy of hematopoietic cells by Medin, Jeffrey A., Karlsson, Stefan

“…Hematopoietic cells, in particular hematopoietic stem cells, are important targets for the development of gene therapy for hematological and other disorders…”
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Characterization of the chimeric retinoic acid receptor RARα/VDR by PEMRICK, S. M, ABARZUA, P, KRATZEISEN, C, MARKS, M. S, MEDIN, J. A, OZATO, K, GRIPPO, J. F

“…The chimeric receptor, RARα/VDR, contains the DNA-binding domain of the retinoic acid receptor (RARα) and the ligand-binding domain of the vitamin D receptor…”
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