Search Results - "Medicines (Basel, Switzerland)"

Does Ortho-Substitution Enhance Cytotoxic Potencies in a Series of 3,5-Bis(benzylidene)-4-piperidones? by Karki, Subhas S., Das, Umashankar, Balzarini, Jan, De Clercq, Erik, Sakagami, Hiroshi, Uesawa, Yoshihiro, Roayapalley, Praveen K., Dimmock, Jonathan R.

“…Background: A series of 3,5-benzylidene-4-piperidones, 1a–n, were prepared to evaluate the hypothesis that the placement of different groups in the…”
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Breathing for Two: Asthma Management, Treatment, and Safety of Pharmacological Therapy during Pregnancy by Javorac, Jovan, Živanović, Dejan, Zvezdin, Biljana, Mijatović Jovin, Vesna

“…The primary objectives of asthma management during pregnancy are to achieve adequate symptom control, reduce the risk of acute exacerbations, and maintain…”
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GDF15 Targeting for Treatment of Hyperemesis Gravidarum by Thygerson, Jamie, Oyler, Dallin, Thomas, Jackson, Muse, Brandon, Brooks, Benjamin D, Pullan, Jessica E

“…Nausea and vomiting during pregnancy (NVP), particularly its severe form, Hyperemesis gravidarum (HG), affects up to 70% of pregnancies and significantly…”
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Postoperative Nausea and Vomiting in the Ambulatory Surgery Center: A Narrative Review by Bell, Justin, Bindelglass, Adam, Morrone, Jennifer, Park, Sherwin, Costa, Ana, Bergese, Sergio

“…Postoperative nausea and vomiting (PONV) is a common complication of ambulatory surgery, leading to numerous deleterious effects such as decreased patient…”
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Deciphering Mechanisms, Prevention Strategies, Management Plans, Medications, and Research Techniques for Strokes in Systemic Lupus Erythematosus by Al-Ewaidat, Ola A, Naffaa, Moawiah M

“…Systemic lupus erythematosus (SLE) is an autoimmune rheumatic condition characterized by an unpredictable course and a wide spectrum of manifestations varying…”
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Cytokine Storm in COVID-19: Insight into Pathological Mechanisms and Therapeutic Benefits of Chinese Herbal Medicines by Yu, Qingyuan, Zhou, Xian, Kapini, Rotina, Arsecularatne, Anthony, Song, Wenting, Li, Chunguang, Liu, Yang, Ren, Junguo, Münch, Gerald, Liu, Jianxun, Chang, Dennis

“…Cytokine storm (CS) is the main driver of SARS-CoV-2-induced acute respiratory distress syndrome (ARDS) in severe coronavirus disease-19 (COVID-19). The…”
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An Unusual Case of Immune Complex-Mediated Membranoproliferative Glomerulonephritis as Renal Manifestation of Idiopathic Hypereosinophilic Syndrome: A Case Report and Literature Review by Cieza-Terrones, Michael, De La Flor, José C, Requejo, Christian, Villa, Daniel, Apaza, Jacqueline, Rodríguez-Doyágüez, Pablo, Zamora, Rocío, Asato-Higa, Carmen, Rivera-Estrella, David, Carrasco-Yalán, Antonio

“…Idiopathic hypereosinophilic syndrome (IHES) is a disorder characterized by abnormal and persistent peripheral blood hypereosinophilia (eosinophil count ≥ 1.5…”
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Incidence and Outcomes of COVID-19 Vaccine Hypersensitivity Reactions and Success of COVID-19 Vaccine Provocation Tests Post Previous COVID-19 Vaccine Hypersensitivity by Kurniawan, Adi, Koesnoe, Sukamto, Yunihastuti, Evy, Shatri, Hamzah

“…: The COVID-19 pandemic has led to high mortality rates. There have been reports of hypersensitivity reactions with mild to severe symptoms. The COVID-19…”
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Medicines-Aims and Scope Updates by Sakagami, Hiroshi

“…The journal (ISSN 2305-6320) was launched in 2014 [...]…”
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A Modern Approach to the Treatment of Traumatic Brain Injury by Syzdykbayev, Marat, Kazymov, Maksut, Aubakirov, Marat, Kurmangazina, Aigul, Kairkhanov, Ernar, Kazangapov, Rustem, Bryzhakhina, Zhanna, Imangazinova, Saule, Sheinin, Anton

“…Traumatic brain injury manifests itself in various forms, ranging from mild impairment of consciousness to severe coma and death. Traumatic brain injury…”
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Human Leucocyte Antigen Genetics in Idiosyncratic Drug-Induced Liver Injury with Evidence Based on the Roussel Uclaf Causality Assessment Method by Teschke, Rolf, Danan, Gaby

“…The human leucocyte antigen (HLA) allele variability was studied in cohorts of patients with idiosyncratic drug-induced liver injury (iDILI). Some reports…”
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Improved Outcomes in Eosinophilic Esophagitis with Higher Medication Possession Ratio by Kolasinski, Nathan T, Pasman, Eric A, Nylund, Cade M, Reeves, Patrick T, Brooks, Daniel I, Lescouflair, Katerina G, Min, Steve B

“…Eosinophilic esophagitis (EoE) disease activity can be caused by treatment non-adherence. Medication possession ratio (MPR) is an established metric of…”
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Triple Silencing of HSP27, cFLIP, and CLU Genes Promotes the Sensitivity of Doxazosin-Induced Apoptosis in PC-3 Prostate Cancer Cells by Cho, Jeong Man, Sun, Sojung, Im, Eunji, Yang, Hyunwon, Yoo, Tag Keun

“…This study investigated how the expression of heat shock protein 27 (HSP27), cellular FLICE-like inhibitory protein (cFLIP), and clusterin (CLU) affects the…”
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ADME Gene-Related Pharmacogenomic Labeling of FDA-Approved Drugs: Comparison with Clinical Pharmacogenetics Implementation Consortium (CPIC) Evidence Levels by Deb, Subrata, Hopefl, Robert, Reeves, Anthony Allen, Cvetkovic, Dena

“…Pharmacogenomics (PGx) can facilitate the transition to patient-specific drug regimens and thus improve their efficacy and reduce toxicity. The aim of this…”
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Dimeric 3,5-Bis(benzylidene)-4-piperidones: Tumor-Selective Cytotoxicity and Structure-Activity Relationships by Das, Swagatika, Roayapalley, Praveen K, Sakagami, Hiroshi, Umemura, Naoki, Gorecki, Dennis K J, Hossain, Mohammad, Kawase, Masami, Das, Umashankar, Dimmock, Jonathan R

“…The objective of this study is to find novel antineoplastic agents that display greater toxicity to malignant cells than to neoplasms. In addition, the…”
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Can a Low-Phosphate Diet for Chronic Kidney Disease Treat Cancer? An Interdisciplinary Literature Review by Brown, Ronald B, Bigelow, Philip

“…Cancer therapeutics have a low success rate in clinical trials. An interdisciplinary approach is needed to translate basic, clinical, and remote fields of…”
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A Multi-Modality Intervention Improves Obesity Bias among Medical Students by Trofymenko, Stephanie, Kutob, Randa, Algotar, Amit

“…: Obesity is linked to chronic diseases in adults and children. Its prevalence continues to grow in the United States, necessitating the need for healthcare…”
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Expression Profiles of Hypoxia-Related Genes of Cancers Originating from Anatomically Similar Locations Using TCGA Database Analysis by Bae, Hye Lim, Jeong, Kyeonghun, Yang, Suna, Jun, Hyeji, Kim, Kwangsoo, Chai, Young Jun

“…Hypoxia is a well-recognized characteristic of the tumor microenvironment of solid cancers. This study aimed to analyze hypoxia-related genes shared by groups…”
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The Impact of Comorbidities and Demographic Factors on Ejection Fraction by Soysaler, Cezara Andreea, Andrei, Cătălina Liliana, Ceban, Octavian, Sinescu, Crina Julieta

“…Heart failure (HF) presents an increasingly significant problem as the population ages. The cause of HF plays a significant role in determining treatment…”
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Association of Malnutrition and High Bleeding Risk with Long-Term Prognosis in Patients with Acute Coronary Syndrome following Percutaneous Coronary Intervention by Kataoka, Hiromitsu, Suzuki, Sayumi, Suzuki, Yuichi, Sato, Ryota, Sano, Makoto, Mogi, Satoshi, Sakamoto, Atsushi, Suwa, Kenichiro, Naruse, Yoshihisa, Ohtani, Hayato, Saotome, Masao, Shimizu, Mikihiro, Odagiri, Keiichi, Maekawa, Yuichiro

“…Malnutrition in cardiovascular disease is associated with poor prognosis, especially in patients with heart failure and acute coronary syndrome (ACS). High…”
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