Search Results - "Medicinal research reviews"

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications by Tuo, Qing‐zhang, Zhang, Shu‐ting, Lei, Peng

“…Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is among the most frequent causes of disability and death worldwide…”
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Inducible nitric oxide synthase: Regulation, structure, and inhibition by Cinelli, Maris A., Do, Ha T., Miley, Galen P., Silverman, Richard B.

“…A considerable number of human diseases have an inflammatory component, and a key mediator of immune activation and inflammation is inducible nitric oxide…”
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Health benefits of resveratrol: Evidence from clinical studies by Singh, Akhand Pratap, Singh, Rachna, Verma, Sumit Singh, Rai, Vipin, Kaschula, Catherine H., Maiti, Pralay, Gupta, Subash Chandra

“…Resveratrol is a polyphenolic nutraceutical that exhibits pleiotropic activities in human subjects. The efficacy, safety, and pharmacokinetics of resveratrol…”
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Antimicrobial peptides: Promising alternatives in the post feeding antibiotic era by Wang, Jiajun, Dou, Xiujing, Song, Jing, Lyu, Yinfeng, Zhu, Xin, Xu, Lin, Li, Weizhong, Shan, Anshan

“…Antimicrobial peptides (AMPs), critical components of the innate immune system, are widely distributed throughout the animal and plant kingdoms. They can…”
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Riluzole and edaravone: A tale of two amyotrophic lateral sclerosis drugs by Jaiswal, Manoj Kumar

“…Over the past decades, a multitude of experimental drugs have been shown to delay disease progression in preclinical animal models of amyotrophic lateral…”
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The role of hypoxia‐inducible factor 1 in tumor immune evasion by You, Li, Wu, Wenda, Wang, Xu, Fang, Liurong, Adam, Vojtech, Nepovimova, Eugenie, Wu, Qinghua, Kuca, Kamil

“…Hypoxia‐inducible factor 1 (HIF‐1) plays an indispensable role in the hypoxic tumor microenvironment. Hypoxia and HIF‐1 are involved in multiple aspects of…”
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Molecular targeting therapies for neuroblastoma: Progress and challenges by Zafar, Atif, Wang, Wei, Liu, Gang, Wang, Xinjie, Xian, Wa, McKeon, Frank, Foster, Jennifer, Zhou, Jia, Zhang, Ruiwen

“…There is an urgent need to identify novel therapies for childhood cancers. Neuroblastoma is the most common pediatric solid tumor, and accounts for ~15% of…”
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Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseases by Panossian, Alexander G., Efferth, Thomas, Shikov, Alexander N., Pozharitskaya, Olga N., Kuchta, Kenny, Mukherjee, Pulok K., Banerjee, Subhadip, Heinrich, Michael, Wu, Wanying, Guo, De‐an, Wagner, Hildebert

“…Adaptogens comprise a category of herbal medicinal and nutritional products promoting adaptability, resilience, and survival of living organisms in stress. The…”
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Understanding the tumor microenvironment for effective immunotherapy by Sadeghi Rad, Habib, Monkman, James, Warkiani, Majid E., Ladwa, Rahul, O'Byrne, Ken, Rezaei, Nima, Kulasinghe, Arutha

“…Advances in immunotherapy have led to durable and long‐term benefits in a subset of patients across a number of solid tumor types. Understanding of the subsets…”
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Machine intelligence in peptide therapeutics: A next‐generation tool for rapid disease screening by Basith, Shaherin, Manavalan, Balachandran, Hwan Shin, Tae, Lee, Gwang

“…Discovery and development of biopeptides are time‐consuming, laborious, and dependent on various factors. Data‐driven computational methods, especially machine…”
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The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update by Lu, Meng-Chen, Ji, Jian-Ai, Jiang, Zheng-Yu, You, Qi-Dong

“…The Keap1–Nrf2–ARE ((Kelch‐like ECH‐Associating protein 1) nuclear factor erythroid 2 related factor 2‐antioxidant response element) pathway is one of the most…”
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Chemical molecular‐based approach to overcome multidrug resistance in cancer by targeting P‐glycoprotein (P‐gp) by Zhang, Hang, Xu, Haiwei, Ashby, Charles R., Assaraf, Yehuda G., Chen, Zhe‐Sheng, Liu, Hong‐Min

“…Multidrug resistance (MDR) remains one of the major impediments for efficacious cancer chemotherapy. Increased efflux of multiple chemotherapeutic drugs by…”
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Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: Where are we today? by Mishra, Chandra B., Tiwari, Manisha, Supuran, Claudiu T.

“…Carbonic anhydrases (CAs, EC 4.2.1.1) are widely distributed metalloenzymes in both prokaryotes and eukaryotes. They efficiently catalyze the reversible…”
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A review in radiomics: Making personalized medicine a reality via routine imaging by Guiot, Julien, Vaidyanathan, Akshayaa, Deprez, Louis, Zerka, Fadila, Danthine, Denis, Frix, Anne‐Noelle, Lambin, Philippe, Bottari, Fabio, Tsoutzidis, Nathan, Miraglio, Benjamin, Walsh, Sean, Vos, Wim, Hustinx, Roland, Ferreira, Marta, Lovinfosse, Pierre, Leijenaar, Ralph T.H.

“…Radiomics is the quantitative analysis of standard‐of‑care medical imaging; the information obtained can be applied within clinical decision support systems to…”
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BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease by Moussa‐Pacha, Nour M., Abdin, Shifaa M., Omar, Hany A., Alniss, Hasan, Al‐Tel, Taleb H.

“…Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder with no current cure. One of the important therapeutic approaches of…”
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JNK signaling in cancer cell survival by Wu, Qinghua, Wu, Wenda, Fu, Bishi, Shi, Lei, Wang, Xu, Kuca, Kamil

“…c‐Jun N‐terminal kinase (JNK) is involved in cancer cell apoptosis; however, emerging evidence indicates that this Janus signaling promotes cancer cell…”
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Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention by Angelova, Plamena R., Esteras, Noemi, Abramov, Andrey Y.

“…The world's population aging progression renders age‐related neurodegenerative diseases to be one of the biggest unsolved problems of modern society. Despite…”
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Biologically active quinoline and quinazoline alkaloids part I by Shang, Xiao‐Fei, Morris‐Natschke, Susan L., Liu, Ying‐Qian, Guo, Xiao, Xu, Xiao‐Shan, Goto, Masuo, Li, Jun‐Cai, Yang, Guan‐Zhou, Lee, Kuo‐Hsiung

“…Quinoline and quinazoline alkaloids, two important classes of N‐based heterocyclic compounds, have attracted tremendous attention from researchers worldwide…”
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Morpholine as a privileged structure: A review on the medicinal chemistry and pharmacological activity of morpholine containing bioactive molecules by Kourounakis, Angeliki P., Xanthopoulos, Dimitrios, Tzara, Ariadni

“…Morpholine is a heterocycle featured in numerous approved and experimental drugs as well as bioactive molecules. It is often employed in the field of medicinal…”
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Artificial intelligence and machine learning‐aided drug discovery in central nervous system diseases: State‐of‐the‐arts and future directions by Vatansever, Sezen, Schlessinger, Avner, Wacker, Daniel, Kaniskan, H. Ümit, Jin, Jian, Zhou, Ming‐Ming, Zhang, Bin

“…Neurological disorders significantly outnumber diseases in other therapeutic areas. However, developing drugs for central nervous system (CNS) disorders…”
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