Search Results - "Medicinal chemistry research"

Hydrazide–hydrazones as potential antimicrobial agents: overview of the literature since 2010 by Popiołek, Łukasz

“…Hydrazide–hydrazone derivatives are present in many bioactive molecules and display a wide variety of biological activities, such as antibacterial,…”
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The synthetic and therapeutic expedition of isoxazole and its analogs by Agrawal, Neetu, Mishra, Pradeep

“…Isoxazole, constituting an important family of five-membered heterocycles with one oxygen atom and one nitrogen atom at adjacent positions is of immense…”
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Development of drugs based on imidazole and benzimidazole bioactive heterocycles: recent advances and future directions by Gaba, Monika, Mohan, Chander

“…Imidazole and benzimidazole rings are the most important nitrogen-containing heterocycles, which are widely explored and utilized by the pharmaceutical…”
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Antimicrobial activity of quaternary ammonium salts: structure-activity relationship by Nadagouda, Mallikarjuna N., Vijayasarathy, Pooja, Sin, Aebin, Nam, Heeyeon, Khan, Sanaullah, Parambath, Javad B. M., Mohamed, Ahmed A., Han, Changseok

“…Compounds with antimicrobial activity have gained much attention in research due to the outbreak of coronavirus disease 2019 (COVID-19). Quaternary ammonium…”
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The history, mechanism, and perspectives of nirmatrelvir (PF-07321332): an orally bioavailable main protease inhibitor used in combination with ritonavir to reduce COVID-19-related hospitalizations by Joyce, Ryan P., Hu, Vivian W., Wang, Jun

“…The rapid development of effective vaccines to combat the SARS-CoV-2 virus has been an effective counter measure to decrease hospitalization and the mortality…”
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In vitro and in vivo biological activities of azulene derivatives with potential applications in medicine by Bakun, Paweł, Czarczynska-Goslinska, Beata, Goslinski, Tomasz, Lijewski, Sebastian

“…Azulene is an aromatic hydrocarbon that possesses a unique chemical structure and interesting biological properties. Azulene derivatives, including guaiazulene…”
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Osthole: an overview of its sources, biological activities, and modification development by Sun, Mingna, Sun, Mingjiao, Zhang, Jianye

“…Osthole, also known as osthol, is a coumarin derivative found in several medicinal plants such as Cnidium monnieri and Angelica pubescens . It can be obtained…”
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Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction by Lee, Sumi, Hu, Longqin

“…Activation of the transcription factor Nrf2 via the Keap1–Nrf2–ARE signaling system regulates the transcription and subsequent expression of cellular…”
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Pyrimidine and fused pyrimidine derivatives as promising protein kinase inhibitors for cancer treatment by Abdellatif, Khaled R. A., Bakr, Rania B.

“…Pyrimidine ring and its fused derivatives including pyrazolo[3,4- d ]pyrimidine, pyrido[2,3- d ]pyrimidine, quinazoline, and furo[2,3- d ]pyrimidine compounds…”
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Development and therapeutic potential of 2-aminothiazole derivatives in anticancer drug discovery by Alizadeh, Seyedeh Roya, Hashemi, Seyedeh Mahdieh

“…Currently, the development of anticancer drug resistance is significantly restricted the clinical efficacy of the most commonly prescribed anticancer drug…”
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Isatin derivatives as broad-spectrum antiviral agents: the current landscape by Elsaman, Tilal, Mohamed, Malik Suliman, Eltayib, Eyman Mohamed, Abdel-aziz, Hatem A., Abdalla, Abualgasim Elgaili, Munir, Muhammad Usman, Mohamed, Magdi Awadalla

“…In recent decades, several viruses have resulted in large outbreaks with serious health, economic and social consequences. The current unprecedented outbreak…”
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Coumarin: a potential nucleus for anti-inflammatory molecules by Bansal, Yogita, Sethi, Purva, Bansal, Gulshan

“…Numerous research reports have indicated the coumarin nucleus as a potential candidate for development of anti-inflammatory drugs. Various phytoconstituents…”
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Promising Schiff bases in antiviral drug design and discovery by Kaushik, Shikha, Paliwal, Sarvesh Kumar, Iyer, Malliga R., Patil, Vaishali M.

“…Emerging and re-emerging illnesses will probably present a new hazard of infectious diseases and have fostered the urge to research new antiviral agents. Most…”
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Review on molnupiravir as a promising oral drug for the treatment of COVID-19 by Zarenezhad, Elham, Marzi, Mahrokh

“…During the COVID-19 pandemic, various drug candidates have been developed, molnupiravir (MK-4482 and EIDD-2801), which is a new orally anti-viral agent under…”
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Indolizine: a biologically active moiety by Sharma, Vikas, Kumar, Vipin

“…The discovery of camptothecin and its analogs was the major breakthrough through which “Indolizine moiety” came into limelight. Although major part of the…”
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Design and antiproliferative and antioxidant activities of furan-based thiosemicarbazides and 1,2,4-triazoles: their structure-activity relationship and SwissADME predictions by Sicak, Yusuf

“…Due to the limited number of drugs in current clinical use, the diverse biological applications of furan have encouraged the preparation of a wide variety of…”
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Recent advances on biologically active coumarin-based hybrid compounds by Yildirim, Metin, Poyraz, Samet, Ersatir, Mehmet

“…Coumarin hybrids have been designed and synthesized as an important new strategy in the field of medicinal chemistry. Coumarin core has been shown to form…”
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The pyridazine heterocycle in molecular recognition and drug discovery by Meanwell, Nicholas A.

“…The pyridazine ring is endowed with unique physicochemical properties, characterized by weak basicity, a high dipole moment that subtends π-π stacking…”
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An update on the discovery and development of reversible covalent inhibitors by Faridoon, Ng, Raymond, Zhang, Guiping, Li, Jie Jack

“…Small molecule drugs that covalently bind irreversibly to their target proteins have several advantages over conventional reversible inhibitors. They include…”
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Anticancer properties of baicalein: a review by Gao, Ying, Snyder, Shane A., Smith, Jaclyn N., Chen, Yi Charlie

“…The constituents of many traditional Chinese herbal remedies are currently at the forefront of modern cancer research. Baicalein, a bioactive flavone widely…”
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