Search Results - "Medici, Giorgio"

Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder by Galvani, Giuseppe, Mottolese, Nicola, Gennaccaro, Laura, Loi, Manuela, Medici, Giorgio, Tassinari, Marianna, Fuchs, Claudia, Ciani, Elisabetta, Trazzi, Stefania

“…CDKL5 deficiency disorder (CDD), a severe neurodevelopmental disorder characterized by early onset epilepsy, intellectual disability, and autistic features, is…”
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Luteolin Treatment Ameliorates Brain Development and Behavioral Performance in a Mouse Model of CDKL5 Deficiency Disorder by Tassinari, Marianna, Mottolese, Nicola, Galvani, Giuseppe, Ferrara, Domenico, Gennaccaro, Laura, Loi, Manuela, Medici, Giorgio, Candini, Giulia, Rimondini, Roberto, Ciani, Elisabetta, Trazzi, Stefania

“…CDKL5 deficiency disorder (CDD), a rare and severe neurodevelopmental disease caused by mutations in the X-linked CDKL5 gene, is characterized by early-onset…”
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CDKL5 deficiency predisposes neurons to cell death through the deregulation of SMAD3 signaling by Fuchs, Claudia, Medici, Giorgio, Trazzi, Stefania, Gennaccaro, Laura, Galvani, Giuseppe, Berteotti, Chiara, Ren, Elisa, Loi, Manuela, Ciani, Elisabetta

“…CDKL5 deficiency disorder (CDD) is a rare encephalopathy characterized by early onset epilepsy and severe intellectual disability. CDD is caused by mutations…”
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Early-onset brain alterations during postnatal development in a mouse model of CDKL5 deficiency disorder by Tassinari, Marianna, Uguagliati, Beatrice, Trazzi, Stefania, Cerchier, Camilla Bruna, Cavina, Ottavia Vera, Mottolese, Nicola, Loi, Manuela, Candini, Giulia, Medici, Giorgio, Ciani, Elisabetta

“…Mutations in the CDKL5 gene are the cause of CDKL5 deficiency disorder (CDD), a rare and severe neurodevelopmental condition characterized by early-onset…”
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Increased DNA Damage and Apoptosis in CDKL5-Deficient Neurons by Loi, Manuela, Trazzi, Stefania, Fuchs, Claudia, Galvani, Giuseppe, Medici, Giorgio, Gennaccaro, Laura, Tassinari, Marianna, Ciani, Elisabetta

“…Mutations in the CDKL5 gene, which encodes a serine/threonine kinase, causes a rare encephalopathy, characterized by early-onset epilepsy and severe…”
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A GABAB receptor antagonist rescues functional and structural impairments in the perirhinal cortex of a mouse model of CDKL5 deficiency disorder by Gennaccaro, Laura, Fuchs, Claudia, Loi, Manuela, Roncacè, Vincenzo, Trazzi, Stefania, Ait-Bali, Yassine, Galvani, Giuseppe, Berardi, Anna Cecilia, Medici, Giorgio, Tassinari, Marianna, Ren, Elisa, Rimondini, Roberto, Giustetto, Maurizio, Aicardi, Giorgio, Ciani, Elisabetta

“…CDKL5 (cyclin-dependent kinase-like 5) deficiency disorder (CDD) is a severe neurodevelopmental encephalopathy characterized by early-onset epilepsy and…”
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Treatment with a GSK-3β/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of CDKL5 Deficiency Disorder by Loi, Manuela, Gennaccaro, Laura, Fuchs, Claudia, Trazzi, Stefania, Medici, Giorgio, Galvani, Giuseppe, Mottolese, Nicola, Tassinari, Marianna, Giorgini, Roberto Rimondini, Milelli, Andrea, Ciani, Elisabetta

“…Mutations in the X-linked cyclin-dependent kinase-like 5 ( ) gene cause a rare neurodevelopmental disorder characterized by early-onset seizures and severe…”
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Functional and Structural Impairments in the Perirhinal Cortex of a Mouse Model of CDKL5 Deficiency Disorder Are Rescued by a TrkB Agonist by Ren, Elisa, Roncacé, Vincenzo, Trazzi, Stefania, Fuchs, Claudia, Medici, Giorgio, Gennaccaro, Laura, Loi, Manuela, Galvani, Giuseppe, Ye, Keqiang, Rimondini, Roberto, Aicardi, Giorgio, Ciani, Elisabetta

“…Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a severe X-linked neurodevelopmental encephalopathy caused by mutations in the gene and…”
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DNA structure directs positioning of the mitochondrial genome packaging protein Abf2p by Chakraborty, Arka, Lyonnais, Sébastien, Battistini, Federica, Hospital, Adam, Medici, Giorgio, Prohens, Rafel, Orozco, Modesto, Vilardell, Josep, Solà, Maria

“…The mitochondrial genome (mtDNA) is assembled into nucleo-protein structures termed nucleoids and maintained differently compared to nuclear DNA, the involved…”
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Cardiac Functional and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder by Loi, Manuela, Bastianini, Stefano, Candini, Giulia, Rizzardi, Nicola, Medici, Giorgio, Papa, Valentina, Gennaccaro, Laura, Mottolese, Nicola, Tassinari, Marianna, Uguagliati, Beatrice, Berteotti, Chiara, Martire, Viviana Lo, Zoccoli, Giovanna, Cenacchi, Giovanna, Trazzi, Stefania, Bergamini, Christian, Ciani, Elisabetta

“…CDKL5 (cyclin-dependent kinase-like 5) deficiency disorder (CDD) is a severe neurodevelopmental disease that mostly affects girls, who are heterozygous for…”
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Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder by Rimondini, Roberto, Ciani, Elisabetta, Zoccoli, Giovanna, Ren, Elisa, Martire, Viviana Lo, Bettini, Simone, Bastianini, Stefano, Trazzi, Stefania, Gennaccaro, Laura, Fuchs, Claudia, Medici, Giorgio

“…CDKL5 disorder is a severe neurodevelopmental disorder caused by mutations in the X-linked CDKL5 (cyclin-dependent kinase-like five) gene. CDKL5 disorder…”
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Correction to: Increased DNA Damage and Apoptosis in CDKL5-Deficient Neurons by Loi, Manuela, Trazzi, Stefania, Fuchs, Claudia, Galvani, Giuseppe, Medici, Giorgio, Gennaccaro, Laura, Tassinari, Marianna, Ciani, Elisabetta

“…The original version of this article unfortunately contained error in Fig. 5a to where a panel is missing…”
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Voluntary Running Improves Behavioral and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder by Mottolese, Nicola, Uguagliati, Beatrice, Tassinari, Marianna, Cerchier, Camilla Bruna, Loi, Manuela, Candini, Giulia, Rimondini, Roberto, Medici, Giorgio, Trazzi, Stefania, Ciani, Elisabetta

“…Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a rare neurodevelopmental disease caused by mutations in the X-linked CDKL5 gene. CDD is…”
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Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5 by Matteoli, Gabriele, Alvente, Sara, Bastianini, Stefano, Berteotti, Chiara, Ciani, Elisabetta, Cinelli, Elenia, Lo Martire, Viviana, Medici, Giorgio, Mello, Tommaso, Miglioranza, Elena, Silvani, Alessandro, Mutolo, Donatella, Zoccoli, Giovanna

“…CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients…”
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CDKL5 protein substitution therapy rescues neurological phenotypes of a mouse model of CDKL5 disorder by Trazzi, Stefania, De Franceschi, Marianna, Fuchs, Claudia, Bastianini, Stefano, Viggiano, Rocchina, Lupori, Leonardo, Mazziotti, Raffaele, Medici, Giorgio, Lo Martire, Viviana, Ren, Elisa, Rimondini, Roberto, Zoccoli, Giovanna, Bartesaghi, Renata, Pizzorusso, Tommaso, Ciani, Elisabetta

“…Abstract Cyclin-dependent kinase like-5 (CDKL5) disorder is a rare neurodevelopmental disease caused by mutations in the CDKL5 gene. The consequent…”
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Pharmacotherapy with sertraline rescues brain development and behavior in a mouse model of CDKL5 deficiency disorder by Fuchs, Claudia, Gennaccaro, Laura, Ren, Elisa, Galvani, Giuseppe, Trazzi, Stefania, Medici, Giorgio, Loi, Manuela, Conway, Erin, Devinsky, Orrin, Rimondini, Roberto, Ciani, Elisabetta

“…Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene cause a severe neurodevelopmental disorder, CDKL5 deficiency disorder (CDD). CDKL5 is…”
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Expression of a Secretable, Cell-Penetrating CDKL5 Protein Enhances the Efficacy of Gene Therapy for CDKL5 Deficiency Disorder by Medici, Giorgio, Tassinari, Marianna, Galvani, Giuseppe, Bastianini, Stefano, Gennaccaro, Laura, Loi, Manuela, Mottolese, Nicola, Alvente, Sara, Berteotti, Chiara, Sagona, Giulia, Lupori, Leonardo, Candini, Giulia, Baggett, Helen Rappe, Zoccoli, Giovanna, Giustetto, Maurizio, Muotri, Alysson, Pizzorusso, Tommaso, Nakai, Hiroyuki, Trazzi, Stefania, Ciani, Elisabetta

“…Although delivery of a wild-type copy of the mutated gene to cells represents the most effective approach for a monogenic disease, proof-of-concept studies…”
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Treatment with FRAX486 rescues neurobehavioral and metabolic alterations in a female mouse model of CDKL5 deficiency disorder by Fuchs, Claudia, Cosentino, Livia, Urbinati, Chiara, Talamo, Maria Cristina, Medici, Giorgio, Quattrini, Maria Cristina, Mottolese, Nicola, Pietraforte, Donatella, Fuso, Andrea, Ciani, Elisabetta, De Filippis, Bianca

“…Introduction CDKL5 deficiency disorder (CDD) is a rare neurodevelopmental condition, primarily affecting girls for which no cure currently exists. Neuronal…”
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Age-Related Cognitive and Motor Decline in a Mouse Model of CDKL5 Deficiency Disorder is Associated with Increased Neuronal Senescence and Death by Gennaccaro, Laura, Fuchs, Claudia, Loi, Manuela, Pizzo, Riccardo, Alvente, Sara, Berteotti, Chiara, Lupori, Leonardo, Sagona, Giulia, Galvani, Giuseppe, Gurgone, Antonia, Raspanti, Alessandra, Medici, Giorgio, Tassinari, Marianna, Trazzi, Stefania, Ren, Elisa, Rimondini, Roberto, Pizzorusso, Tommaso, Zoccoli, Giovanna, Giustetto, Maurizio, Ciani, Elisabetta

“…CDKL5 deficiency disorder (CDD) is a severe neurodevelopmental disease caused by mutations in the X-linked gene. Children affected by CDD display a clinical…”
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A GABA B receptor antagonist rescues functional and structural impairments in the perirhinal cortex of a mouse model of CDKL5 deficiency disorder by Gennaccaro, Laura, Fuchs, Claudia, Loi, Manuela, Roncacè, Vincenzo, Trazzi, Stefania, Ait-Bali, Yassine, Galvani, Giuseppe, Berardi, Anna Cecilia, Medici, Giorgio, Tassinari, Marianna, Ren, Elisa, Rimondini, Roberto, Giustetto, Maurizio, Aicardi, Giorgio, Ciani, Elisabetta

“…CDKL5 (cyclin-dependent kinase-like 5) deficiency disorder (CDD) is a severe neurodevelopmental encephalopathy characterized by early-onset epilepsy and…”
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