Search Results - "Mediavilla, Laura"
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Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder
Published in Disease models & mechanisms (01-09-2017)“…Neural stem/progenitor cells (NPCs) generate new neurons in the brain throughout an individual's lifetime in an intricate process called neurogenesis…”
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Synthesis and Neuroprotective Properties of N‑Substituted C‑Dialkoxyphosphorylated Nitrones
Published in ACS omega (31-05-2019)“…Herein, we report the synthesis and neuroprotective power of some N-substituted C-(dialkoxy)phosphorylated nitrones 4a–g, by studying their ability to…”
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Modelling the contributions to hyperexcitability in a mouse model of Alzheimer's disease
Published in The Journal of physiology (01-08-2023)“…Neuronal hyperexcitability is a pathological characteristic of Alzheimer's disease (AD). Three main mechanisms have been proposed to explain it: (i) dendritic…”
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A general principle of dendritic constancy: A neuron’s size- and shape-invariant excitability
Published in Neuron (Cambridge, Mass.) (17-11-2021)“…Reducing neuronal size results in less membrane and therefore lower input conductance. Smaller neurons are thus more excitable, as seen in their responses to…”
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Synthesis of Novel Bifunctional Michael Acceptors
Published in European journal of organic chemistry (01-11-2004)“…The conjugated dienones 1a, 1c−e, and 1g were synthesized by aldol reaction of cyclohex‐2‐enones 3 with aldehydes or ketones and subsequent elimination…”
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Hospitalización domiciliaria en un área rural, ¿una alternativa a la hospitalización tradicional?
Published in Hospital a domicilio (01-09-2020)“…Introducción: El servicio de hospitalización domiciliaria en el área rural es un servicio poco conocido en el resto del ámbito sanitario. Al mismo tiempo…”
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Rhodium-catalyzed enantioselective 1,4-additions of arylboronic acids to substituted enones
Published in Tetrahedron: asymmetry (20-02-2006)“…The rhodium-catalyzed enantioselective 1,4-addition of arylboronic acids to the bifunctional Michael acceptors 1– 3 in the presence of phosphoramidites L2– L4…”
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Epimerization and kinetic resolution in copper-catalyzed enantioselective 1,4-additions of organozinc reagents to 6-substituted cyclohex-2-enones
Published in Tetrahedron letters (28-10-2002)“…Enantioselective 1,4-addition reactions of diethyl-, dimethyl-, and di- n-butylzinc to 6-methylcyclohex-2-enone ( 1 ) and 6- t-butylcyclohex-2-enone ( 4 ),…”
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