Search Results - "Mediani, Laura"

A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism by Ganassi, Massimo, Mateju, Daniel, Bigi, Ilaria, Mediani, Laura, Poser, Ina, Lee, Hyun O., Seguin, Samuel J., Morelli, Federica F., Vinet, Jonathan, Leo, Giuseppina, Pansarasa, Orietta, Cereda, Cristina, Poletti, Angelo, Alberti, Simon, Carra, Serena

“…Stress granules (SGs) are ribonucleoprotein complexes induced by stress. They sequester mRNAs and disassemble when the stress subsides, allowing translation…”
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BAG3 Pro209 mutants associated with myopathy and neuropathy relocate chaperones of the CASA-complex to aggresomes by Adriaenssens, Elias, Tedesco, Barbara, Mediani, Laura, Asselbergh, Bob, Crippa, Valeria, Antoniani, Francesco, Carra, Serena, Poletti, Angelo, Timmerman, Vincent

“…Three missense mutations targeting the same proline 209 (Pro209) codon in the co-chaperone Bcl2-associated athanogene 3 (BAG3) have been reported to cause…”
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Studying heat shock proteins through single-molecule mechanical manipulation by Choudhary, Dhawal, Mediani, Laura, Carra, Serena, Cecconi, Ciro

“…Imbalances of cellular proteostasis are linked to ageing and human diseases, including neurodegenerative and neuromuscular diseases. Heat shock proteins (HSPs)…”
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HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain by Boczek, Edgar E, Fürsch, Julius, Niedermeier, Marie Laura, Jawerth, Louise, Jahnel, Marcus, Ruer-Gruß, Martine, Kammer, Kai-Michael, Heid, Peter, Mediani, Laura, Wang, Jie, Yan, Xiao, Pozniakovski, Andrej, Poser, Ina, Mateju, Daniel, Hubatsch, Lars, Carra, Serena, Alberti, Simon, Hyman, Anthony A, Stengel, Florian

“…Aberrant liquid-to-solid phase transitions of biomolecular condensates have been linked to various neurodegenerative diseases. However, the underlying…”
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Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor by Tiago, Tatiana, Hummel, Barbara, Morelli, Federica F., Basile, Valentina, Vinet, Jonathan, Galli, Veronica, Mediani, Laura, Antoniani, Francesco, Pomella, Silvia, Cassandri, Matteo, Garone, Maria Giovanna, Silvestri, Beatrice, Cimino, Marco, Cenacchi, Giovanna, Costa, Roberta, Mouly, Vincent, Poser, Ina, Yeger-Lotem, Esti, Rosa, Alessandro, Alberti, Simon, Rota, Rossella, Ben-Zvi, Anat, Sawarkar, Ritwick, Carra, Serena

“…One of the critical events that regulates muscle cell differentiation is the replacement of the lamin B receptor (LBR)-tether with the lamin A/C (LMNA)-tether…”
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Alternatively spliced exon regulates context-dependent MEF2D higher-order assembly during myogenesis by Gönczi, Mónika, Teixeira, João M. C., Barrera-Vilarmau, Susana, Mediani, Laura, Antoniani, Francesco, Nagy, Tamás Milán, Fehér, Krisztina, Ráduly, Zsolt, Ambrus, Viktor, Tőzsér, József, Barta, Endre, Kövér, Katalin E., Csernoch, László, Carra, Serena, Fuxreiter, Monika

“…During muscle cell differentiation, the alternatively spliced, acidic β-domain potentiates transcription of Myocyte-specific Enhancer Factor 2 (Mef2D)…”
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Protein products of nonstop mRNA disrupt nucleolar homeostasis by Davis, Zoe H., Mediani, Laura, Antoniani, Francesco, Vinet, Jonathan, Li, Shuangxi, Alberti, Simon, Lu, Bingwei, Holehouse, Alex S., Carra, Serena, Brandman, Onn

“…Stalled mRNA translation results in the production of incompletely synthesized proteins that are targeted for degradation by ribosome-associated quality…”
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Aberrant Compartment Formation by HSPB2 Mislocalizes Lamin A and Compromises Nuclear Integrity and Function by Morelli, Federica F., Verbeek, Dineke S., Bertacchini, Jessika, Vinet, Jonathan, Mediani, Laura, Marmiroli, Sandra, Cenacchi, Giovanna, Nasi, Milena, De Biasi, Sara, Brunsting, Jeanette F., Lammerding, Jan, Pegoraro, Elena, Angelini, Corrado, Tupler, Rossella, Alberti, Simon, Carra, Serena

“…Small heat shock proteins (HSPBs) contain intrinsically disordered regions (IDRs), but the functions of these IDRs are still unknown. Here, we report that, in…”
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BAG3 and BAG6 differentially affect the dynamics of stress granules by targeting distinct subsets of defective polypeptides released from ribosomes by Mediani, Laura, Galli, Veronica, Carrà, Arianna Dorotea, Bigi, Ilaria, Vinet, Jonathan, Ganassi, Massimo, Antoniani, Francesco, Tiago, Tatiana, Cimino, Marco, Mateju, Daniel, Cereda, Cristina, Pansarasa, Orietta, Alberti, Simon, Mandrioli, Jessica, Carra, Serena

“…Stress granules (SGs) are dynamic ribonucleoprotein granules induced by environmental stresses. They play an important role in the stress response by…”
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Heat Shock Proteins: Important Helpers for the Development, Maintenance and Regeneration of Skeletal Muscles by Pomella, Silvia, Cassandri, Matteo, Antoniani, Francesco, Crotti, Samuele, Mediani, Laura, Silvestri, Beatrice, Medici, Margherita, Rota, Rossella, Rosa, Alessandro, Carra, Serena

“…The skeletal muscle is a highly plastic tissue that shows a remarkable adaptive capacity in response to acute and resistance exercise, and modifies its…”
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Loss of PML nuclear bodies in familial amyotrophic lateral sclerosis-frontotemporal dementia by Antoniani, Francesco, Cimino, Marco, Mediani, Laura, Vinet, Jonathan, Verde, Enza M., Secco, Valentina, Yamoah, Alfred, Tripathi, Priyanka, Aronica, Eleonora, Cicardi, Maria E., Trotti, Davide, Sterneckert, Jared, Goswami, Anand, Carra, Serena

“…Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are two neurodegenerative disorders that share genetic causes and pathogenic mechanisms…”
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Reversal of the glycolytic phenotype of primary effusion lymphoma cells by combined targeting of cellular metabolism and PI3K/Akt/ mTOR signaling by Mediani, Laura, Gibellini, Federica, Bertacchini, Jessika, Frasson, Chiara, Bosco, Raffaella, Accordi, Benedetta, Basso, Giuseppe, Bonora, Massimo, Calabrò, Maria Luisa, Mattiolo, Adriana, Sgarbi, Gianluca, Baracca, Alessandra, Pinton, Paolo, Riva, Giovanni, Rampazzo, Enrico, Petrizza, Luca, Prodi, Luca, Milani, Daniela, Luppi, Mario, Potenza, Leonardo, De Pol, Anto, Cocco, Lucio, Capitani, Silvano, Marmiroli, Sandra

“…PEL is a B-cell non-Hodgkin lymphoma, occurring predominantly as a lymphomatous effusion in body cavities, characterized by aggressive clinical course, with no…”
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Targeting PI3K/AKT/mTOR network for treatment of leukemia by Bertacchini, Jessika, Heidari, Nazanin, Mediani, Laura, Capitani, Silvano, Shahjahani, Mohammad, Ahmadzadeh, Ahmad, Saki, Najmaldin

“…OBJECTIVE: Increased activity of PI3K/AKT/mTOR pathway has been observed in a huge number of malignancies. This pathway can function as a prosurvival factor in…”
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ALS and FTD: Where RNA metabolism meets protein quality control by Mandrioli, Jessica, Mediani, Laura, Alberti, Simon, Carra, Serena

“…Recent genetic and biochemical evidence has improved our understanding of the pathomechanisms that lead to amyotrophic lateral sclerosis (ALS) and…”
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Granulostasis: Protein Quality Control of RNP Granules by Alberti, Simon, Mateju, Daniel, Mediani, Laura, Carra, Serena

“…Ribonucleoprotein (RNP) granules transport, store, or degrade messenger RNAs, thereby indirectly regulating protein synthesis. Normally, RNP granules are…”
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Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin by Mediani, Laura, Guillén‐Boixet, Jordina, Vinet, Jonathan, Franzmann, Titus M, Bigi, Ilaria, Mateju, Daniel, Carrà, Arianna D, Morelli, Federica F, Tiago, Tatiana, Poser, Ina, Alberti, Simon, Carra, Serena

“…Nuclear protein aggregation has been linked to genome instability and disease. The main source of aggregation‐prone proteins in cells is defective ribosomal…”
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Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling by Mediani, Laura, Antoniani, Francesco, Galli, Veronica, Vinet, Jonathan, Carrà, Arianna Dorotea, Bigi, Ilaria, Tripathy, Vadreenath, Tiago, Tatiana, Cimino, Marco, Leo, Giuseppina, Amen, Triana, Kaganovich, Daniel, Cereda, Cristina, Pansarasa, Orietta, Mandrioli, Jessica, Tripathi, Priyanka, Troost, Dirk, Aronica, Eleonora, Buchner, Johannes, Goswami, Anand, Sterneckert, Jared, Alberti, Simon, Carra, Serena

“…Stress granules (SGs) are dynamic condensates associated with protein misfolding diseases. They sequester stalled mRNAs and signaling factors, such as the…”
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Human Small Heat Shock Protein B8 Inhibits Protein Aggregation without Affecting the Native Folding Process by Choudhary, Dhawal, Mediani, Laura, Avellaneda, Mario J., Bjarnason, Sveinn, Alberti, Simon, Boczek, Edgar E., Heidarsson, Pétur O., Mossa, Alessandro, Carra, Serena, Tans, Sander J., Cecconi, Ciro

“…Small Heat Shock Proteins (sHSPs) are key components of our Protein Quality Control system and are thought to act as reservoirs that neutralize irreversible…”
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Missense mutation in ATXN2 gene (c.2860C > T) in an amyotrophic lateral sclerosis patient with aggressive disease phenotype by Ghezzi, Andrea, Martinelli, Ilaria, Carra, Serena, Mediani, Laura, Zucchi, Elisabetta, Simonini, Cecilia, Gianferrari, Giulia, Fini, Nicola, Cereda, Cristina, Gellera, Cinzia, Pensato, Viviana, Mandrioli, Jessica

“…Background ALS symptoms have been previously described only in the context of ATXN2 CAG expansions, whereas missense mutations of the gene have never been…”
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The protein kinase Akt/PKB regulates both prelamin A degradation and Lmna gene expression by Bertacchini, Jessika, Beretti, Francesca, Cenni, Vittoria, Guida, Marianna, Gibellini, Federica, Mediani, Laura, Marin, Oriano, Maraldi, Nadir M., Pol, Anto, Lattanzi, Giovanna, Cocco, Lucio, Marmiroli, Sandra

“…The serine/threonine kinase Akt/PKB is a major signaling hub integrating metabolic, survival, growth, and cell cycle regulatory signals. The definition of the…”
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