Search Results - "Medghalchi, Susan M"

Selective Inhibition of Fatty Acid Synthase for Lung Cancer Treatment by ORITA, Hajime, COULTER, Jonathan, LEMMON, Colleen, TULLY, Ellen, VADLAMUDI, Aravinda, MEDGHALCHI, Susan M, KUHAJDA, Francis P, GABRIELSON, Edward

“…Purpose: Fatty acid synthase (FAS) is overexpressed in many human cancers and is considered to be a promising target for therapy. However, in vitro use of…”
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Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells by WEIBO ZHOU, WAN FANG HAN, RONNETT, Gabriele V, TOWNSEND, Craig A, KUHAJDA, Francis P, LANDREE, Leslie E, THUPARI, Jagan N, PINN, Michael L, BILILIGN, Tsion, EUN KYOUNG KIM, VADLAMUDI, Aravinda, MEDGHALCHI, Susan M, EL MESKINI, Rajaa

“…Fatty acid synthase (FAS), the enzyme responsible for the de novo synthesis of fatty acids, is highly expressed in ovarian cancers and most common human…”
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Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity by Kuhajda, Francis P, Aja, Susan, Tu, Yajun, Han, Wan Fang, Medghalchi, Susan M, El Meskini, Rajaa, Landree, Leslie E, Peterson, Jonathan M, Daniels, Khadija, Wong, Kody, Wydysh, Edward A, Townsend, Craig A, Ronnett, Gabriele V

“…Storage of excess calories as triglycerides is central to obesity and its associated disorders. Glycerol-3-phosphate acyltransferases (GPATs) catalyze the…”
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Application of a Flexible Synthesis of (5R)-Thiolactomycin To Develop New Inhibitors of Type I Fatty Acid Synthase by McFadden, Jill M, Medghalchi, Susan M, Thupari, Jagan N, Pinn, Michael L, Vadlamudi, Aravinda, Miller, Katherine I, Kuhajda, Francis P, Townsend, Craig A

“…Fatty acid synthase (FAS) catalyzes the synthesis of palmitate from the sequential condensation of an acetyl primer with two carbon units added from…”
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Design and Synthesis of Small Molecule Glycerol 3-Phosphate Acyltransferase Inhibitors by Wydysh, Edward A, Medghalchi, Susan M, Vadlamudi, Aravinda, Townsend, Craig A

“…The incidence of obesity and other diseases associated with an increased triacylglycerol mass is growing rapidly, particularly in the United States. Glycerol…”
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Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells by ZHOU, Weibo, SIMPSON, P. Jeanette, MCFADDEN, Jill M, TOWNSEND, Craig A, MEDGHALCHI, Susan M, VADLAMUDI, Aravinda, PINN, Michael L, RONNETT, Gabriele V, KUHAJDA, Francis P

“…C75, an inhibitor of fatty acid synthase (FAS), induces apoptosis in cultured human cancer cells. Its proposed mechanism of action linked high levels of…”
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Design, synthesis, and biological evaluation of conformationally constrained glycerol 3-phosphate acyltransferase inhibitors by Wydysh, Edward A., Vadlamudi, Aravinda, Medghalchi, Susan M., Townsend, Craig A.

“…Glycerol 3-phosphate acyltransferase (GPAT) isozymes are central control points for fat synthesis in mammals. Development of inhibitors of these membrane-bound…”
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Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability by MEDGHALCHI, Susan M, FRISCHMEYER, Pamela A, MENDELL, Joshua T, KELLY, Amy G, LAWLER, Ann M, DIETZ, Harry C

“…The ability to detect and degrade transcripts that lack full coding potential is ubiquitous but non-essential in lower eukaryotes, leaving in question the…”
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Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight by Aja, Susan, Landree, Leslie E, Kleman, Amy M, Medghalchi, Susan M, Vadlamudi, Aravinda, McFadden, Jill M, Aplasca, Andrea, Hyun, Jayson, Plummer, Erica, Daniels, Khadija, Kemm, Matthew, Townsend, Craig A, Thupari, Jagan N, Kuhajda, Francis P, Moran, Timothy H, Ronnett, Gabriele V

“…Inhibition of brain carnitine palmitoyl-transferase-1 (CPT-1) is reported to decrease food intake and body weight in rats. Yet, the fatty acid synthase (FAS)…”
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Novel Upf2p Orthologues Suggest a Functional Link between Translation Initiation and Nonsense Surveillance Complexes by Mendell, Joshua T., Medghalchi, Susan M., Lake, Ross G., Noensie, Erick N., Dietz, Harry C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mammalian Orthologues of a Yeast Regulator of Nonsense Transcript Stability by Perlick, Haley A., Medghalchi, Susan M., Spencer, Forrest A., Kendzior, Raymond J., Dietz, Harry C.

“…All eukaryotes that have been studied to date possess the ability to detect and degrade transcripts that contain a premature signal for the termination of…”
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