Search Results - "Medford, R M"

Oxidative Stress as a Regulator of Gene Expression in the Vasculature by Kunsch, Charles, Medford, Russell M

“…Oxidative stress and the production of intracellular reactive oxygen species (ROS) have been implicated in the pathogenesis of a variety of diseases. In…”
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Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells by MARUI, N, OFFERMANN, M. K, SWERLICK, R, KUNSCH, C, ROSEN, C. A, MUSHTAQ AHMAD, ALEXANDER, R. W, MEDFORD, R. M

“…Oxidative stress and expression of the vascular cell adhesion molecule-1 (VCAM-1) on vascular endothelial cells are early features in the pathogenesis of…”
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Oscillatory Shear Stress Stimulates Adhesion Molecule Expression in Cultured Human Endothelium by Chappell, David C, Varner, Signe E, Nerem, Robert M, Medford, Russell M, Alexander, Wayne R

“…Low and oscillatory shear stresses are major features of the hemodynamic environment of sites opposite arterial flow dividers that are predisposed to…”
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Angiotensin II Induces Monocyte Chemoattractant Protein-1 Gene Expression in Rat Vascular Smooth Muscle Cells by Chen, Xi-Lin, Tummala, Pradyumna E, Olbrych, Matthew T, Alexander, R. Wayne, Medford, Russell M

“…Monocyte infiltration into the vessel wall, a key initial step in the process of atherosclerosis, is mediated in part by monocyte chemoattractant protein-1…”
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Angiotensin II induces vascular cell adhesion molecule-1 expression in rat vasculature : A potential link between the renin-angiotensin system and atherosclerosis by TUMMALA, P. E, CHEN, X.-L, SUNDELL, C. L, LAURSEN, J. B, HAMMES, C. P, ALEXANDER, R. W, HARRISON, D. G, MEDFORD, R. M

“…Cardiovascular ischemic events may occur more frequently in hypertensive patients with activated renin-angiotensin systems. We tested the hypothesis that…”
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Nitric Oxide Regulates Vascular Cell Adhesion Molecule 1 Gene Expression and Redox-Sensitive Transcriptional Events in Human Vascular Endothelial Cells by Khan, Bobby V., Harrison, David G., Olbrych, Matthew T., Alexander, R. Wayne, Medford, Russell M.

“…Decreased nitric oxide (NO) activity, the formation of reactive oxygen species, and increased endothelial expression of the redox-sensitive vascular cell…”
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Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells by Khan, B V, Parthasarathy, S S, Alexander, R W, Medford, R M

“…Early features in the pathogenesis of atherosclerosis include accumulation of oxidized LDL (oxLDL) and endothelial expression of the vascular adhesion molecule…”
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Aldosterone-mediated regulation of Na+, K(+)-ATPase gene expression in adult and neonatal rat cardiocytes by IKEDA, U, HYMAN, R, SMITH, T. W, MEDFORD, R. M

“…By altering the Na+/K+ electrochemical gradient, Na+,K(+)-ATPase activity profoundly influences cardiac cell excitability and contractility. The recent finding…”
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Laminar flow induction of antioxidant response element-mediated genes in endothelial cells. A novel anti-inflammatory mechanism by Chen, Xi-Lin, Varner, Signe E, Rao, Anjali S, Grey, Janice Y, Thomas, Suzanne, Cook, Christopher K, Wasserman, Martin A, Medford, Russell M, Jaiswal, Anil K, Kunsch, Charles

“…Atherosclerotic lesions preferentially develop in areas of the vasculature exposed to nonlaminar blood flow and low fluid shear stress, whereas laminar flow…”
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Regulation of Na-K-ATPase gene expression by aldosterone in vascular smooth muscle cells by Oguchi, A, Ikeda, U, Kanbe, T, Tsuruya, Y, Yamamoto, K, Kawakami, K, Medford, R M, Shimada, K

“…Na-K-adenosinetriphosphatase (ATPase) activity profoundly influences vascular cell excitability, contractility, and volume regulation. The recent finding of…”
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Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells by MIDDLETON, J. P, KHAN, W. A, COLLINSWORTH, G, HANNUN, Y. A, MEDFORD, R. M

“…Na/K-ATPase in renal epithelium is expressed at the basolateral surface and thus is critical for vectorial solute transport. One potential mode of regulation…”
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Role of activating protein-1 in the regulation of the vascular cell adhesion molecule-1 gene expression by tumor necrosis factor-alpha by Ahmad, M, Theofanidis, P, Medford, R M

“…Endothelial cell surface expression of VCAM-1 is one of the initial steps in the pathogenesis of atherosclerosis. The inflammatory response transcription…”
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Hyperglycemia-induced activation of nuclear transcription factor κB in vascular smooth muscle cells by YERNENI, K. K. V, WEI BAI, KHAN, B. V, MEDFORD, R. M, NATARAJAN, R

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Regulation of Na,K-ATPase Gene Expression by Thyroid Hormone in Rat Cardiocytes by Kamitani, Tsuyoshi, Ikeda, Uichi, Muto, Shigeaki, Kawakami, Kiyoshi, Nagano, Kei, Tsuruya, Yoshio, Oguchi, Asahiko, Yamamoto, Keiji, Hara, Yukichi, Kojima, Toshiyuki, Medford, Russell M, Shimada, Kazuyuki

“…Synthesis and activity of the enzymatic equivalent of the sodium pump, Na,K-ATPase, are regulated by thyroid hormone in responsive tissues. The purpose of this…”
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Vascular smooth muscle expresses a truncated Na+, K(+)-ATPase alpha-1 subunit isoform by MEDFORD, R. M, HYMAN, R, AHMAD, M, ALLEN, J. C, PRESSLEY, T. A, ALLEN, P. D, NADAL-GINARD, B

“…By regulating transmembrane Na+ and K+ concentrations and membrane potential, the Na+,K(+)-ATPase plays an important role in regulating cardiac, skeletal, and…”
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Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene by Breitbart, R E, Nguyen, H T, Medford, R M, Destree, A T, Mahdavi, V, Nadal-Ginard, B

“…Mechanisms of alternative RNA splicing, important in the generation of protein diversity, are common but incompletely understood. Among the contractile…”
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Transcriptional and cell cycle-mediated regulation of myosin heavy chain gene expression during muscle cell differentiation by Medford, R M, Nguyen, H T, Nadal-Ginard, B

“…The molecular mechanisms regulating the induction of myosin heavy chain (MHC) gene expression during muscle cell differentiation were studied using a MHC cDNA…”
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Antioxidant-sensitive regulation of inflammatory-response genes in Kaposi's sarcoma cells by OFFERMANN, M. K, LIN, J.-C, MAR, E.-C, SHAW, R, YANG, J, MEDFORD, R. M

“…Kaposi's sarcoma (KS) is a multifocal vascular lesion characterized by abnormal proliferation of endothelial-like KS cells linked to a pronounced leukocyte…”
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Disproportionate α- and βmRNA Sodium Pump Subunit Content in Canine Vascular Smooth Muscle by Allen, Julius C, Medford, Russell M, Zhao, Xun, Pressley, Thomas A

“…Total RNA isolated from canine saphenous vein smooth muscle cells was examined for Na pump α- and β-mRNA content by three increasingly sensitive…”
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Reversibility of muscle differentiation in the absence of commitment: analysis of a myogenic cell line temperature-sensitive for commitment by Nguyen, H T, Medford, R M, Nadal-Ginard, B

“…The interrelationship between commitment (irreversible withdrawal from the cell cycle) and muscle-specific gene expression was analyzed with the myogenic cell…”
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