Evaluation of the antimicrobial effect of the Origanum vulgare L essential oil on strains of Klebsiella pneumoniae

Evaluation of the antimicrobial effect of the Origanum vulgare L essential oil on strains of Klebsiella pneumoniae

Bacteria may be the initial cause of certain pathologies as well as a secondary agent responsible for the development of complications such as pressure ulcer infections. Pressure ulcers are a persistent health problem, especially in immunocompromised patients, and associated with infection by opport...

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Published in:Brazilian journal of biology Vol. 83; p. e269317
Main Authors: Silva, S L, Araújo, F S M, Silva, P O A, Silva, E V A, Bezerra, M M S L, Diniz, A F, Oliveira, D M, Jesus, H O, Nascimento Junior, B B, Medeiros, L A D M, Oliveira Filho, A A
Format: Journal Article
Language:English
Published: Brazil Instituto Internacional de Ecologia 2023
Subjects:
Ampicillin
Anti-Bacterial Agents - pharmacology
antibacterial activity
antimicrobial agents
BIOLOGY
Gentamicins
Humans
Klebsiella pneumoniae
microbiology
Oils, Volatile - pharmacology
Origanum
Origanum vulgare L
antibacterial activity
microbiologia
Origanum vulgare L
antimicrobial agents
antimicrobianos
atividade antibacteriana
microbiology
Klebsiella pneumoniae
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Summary:Bacteria may be the initial cause of certain pathologies as well as a secondary agent responsible for the development of complications such as pressure ulcer infections. Pressure ulcers are a persistent health problem, especially in immunocompromised patients, and associated with infection by opportunistic microorganisms with antimicrobial resistance, such as Klebsiella pneumoniae, highlight the need for the development of new antimicrobial approaches. Thus, the aim of this study was to evaluate the antibacterial and anti-adherent activity of Origanum vulgare L. (oregano) essential oil against Klebsiella pneumoniae strains, as well as the effect of its association with synthetic antimicrobials. To this end, the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) analyses were performed on microdilution plates. The assay of the Minimum Inhibitory Adherence Concentration (MIAC), with test tubes. As well as, the association study through the infusion disc method containing ampicillin (AMP), gentamicin (GEN), ciprofloxacin (CIP) and ceftriaxone (CEF). Therefore, it was possible to obtain that the essential oil of oregano presents antimicrobial and bactericidal activity, with MIC ranging between 128μg/mL and 256 μg/mL and MBC between 256 μg/mL and 512 μg/mL, on the tested K. pneumoniae strains. When used in association with ampicillin and gentamicin, oregano essential oil showed synergistic effect for some strains. Therefore, it is observed that the tested essential oil can act as a promising antibacterial in the treatment of diseases caused by K. pneumoniae.
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ISSN:1519-6984
1678-4375
1678-4375
DOI:10.1590/1519-6984.269317