Search Results - "Medalia, Ohad"

The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein by Qi, Chao, Sorrentino, Simona, Medalia, Ohad, Korkhov, Volodymyr M

“…Membrane-integral adenylyl cyclases (ACs) are key enzymes in mammalian heterotrimeric GTP-binding protein (G protein)-dependent signal transduction, which is…”
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Lamins: the structure and protein complexes by Gruenbaum, Yosef, Medalia, Ohad

“…Lamins are nuclear intermediate filament (IF) proteins. They assemble to fibrous structures that are positioned between the inner nuclear membrane and the…”
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Functional Architecture of the Nuclear Pore Complex by Grossman, Einat, Medalia, Ohad, Zwerger, Monika

“…The nuclear pore complex (NPC) is the sole gateway between the nucleus and the cytoplasm. NPCs fuse the inner and outer nuclear membranes to form aqueous…”
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The Human Nuclear Pore Complex as Revealed by Cryo-Electron Tomography by Maimon, Tal, Elad, Nadav, Dahan, Idit, Medalia, Ohad

“…Nuclear pore complexes (NPCs) are the sole passage through the nuclear envelope, connecting the cytoplasm to the nucleoplasm. These gigantic molecular…”
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The molecular architecture of lamins in somatic cells by Turgay, Yagmur, Eibauer, Matthias, Goldman, Anne E., Shimi, Takeshi, Khayat, Maayan, Ben-Harush, Kfir, Dubrovsky-Gaupp, Anna, Sapra, K. Tanuj, Goldman, Robert D., Medalia, Ohad

“…Cryo-electron tomography reveals a detailed view of the structural organization of the lamin meshwork within the lamina of the mammalian cell nucleus. The…”
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Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina by Sapra, K. Tanuj, Qin, Zhao, Dubrovsky-Gaupp, Anna, Aebi, Ueli, Müller, Daniel J., Buehler, Markus J., Medalia, Ohad

“…The nuclear lamina—a meshwork of intermediate filaments termed lamins—is primarily responsible for the mechanical stability of the nucleus in multicellular…”
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Structure and gating of the nuclear pore complex by Eibauer, Matthias, Pellanda, Mauro, Turgay, Yagmur, Dubrovsky, Anna, Wild, Annik, Medalia, Ohad

“…Nuclear pore complexes (NPCs) perforate the nuclear envelope and allow the exchange of macromolecules between the nucleus and the cytoplasm. To acquire a…”
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Structural basis for the activation and ligand recognition of the human oxytocin receptor by Waltenspühl, Yann, Ehrenmann, Janosch, Vacca, Santiago, Thom, Cristian, Medalia, Ohad, Plückthun, Andreas

“…The small cyclic neuropeptide hormone oxytocin (OT) and its cognate receptor play a central role in the regulation of social behaviour and sexual reproduction…”
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The Nuclear Pore Complex: Birth, Life, and Death of a Cellular Behemoth by Dultz, Elisa, Wojtynek, Matthias, Medalia, Ohad, Onischenko, Evgeny

“…Nuclear pore complexes (NPCs) are the only transport channels that cross the nuclear envelope. Constructed from ~500-1000 nucleoporin proteins each, they are…”
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Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy by Weber, Miriam S, Eibauer, Matthias, Sivagurunathan, Suganya, Magin, Thomas M, Goldman, Robert D, Medalia, Ohad

“…Keratin intermediate filaments are an essential and major component of the cytoskeleton in epithelial cells. They form a stable yet dynamic filamentous network…”
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Tiopronin-Protected Gold Nanoparticles as a Potential Marker for Cryo-EM and Tomography by Dahan, Idit, Sorrentino, Simona, Boujemaa-Paterski, Rajaa, Medalia, Ohad

“…Gold nanoparticles (AuNPs) and their conjugation to biological samples have numerous potential applications. When combined with cryo-electron microscopy and…”
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Talin-activated vinculin interacts with branched actin networks to initiate bundles by Boujemaa-Paterski, Rajaa, Martins, Bruno, Eibauer, Matthias, Beales, Charlie T, Geiger, Benjamin, Medalia, Ohad

“…Vinculin plays a fundamental role in integrin-mediated cell adhesion. Activated by talin, it interacts with diverse adhesome components, enabling mechanical…”
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Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control by Schmid, Markus, Ernst, Patrick, Honegger, Annemarie, Suomalainen, Maarit, Zimmermann, Martina, Braun, Lukas, Stauffer, Sarah, Thom, Cristian, Dreier, Birgit, Eibauer, Matthias, Kipar, Anja, Vogel, Viola, Greber, Urs F., Medalia, Ohad, Plückthun, Andreas

“…Most systemic viral gene therapies have been limited by sequestration and degradation of virions, innate and adaptive immunity, and silencing of therapeutic…”
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Allosteric activation of vinculin by talin by Franz, Florian, Tapia-Rojo, Rafael, Winograd-Katz, Sabina, Boujemaa-Paterski, Rajaa, Li, Wenhong, Unger, Tamar, Albeck, Shira, Aponte-Santamaria, Camilo, Garcia-Manyes, Sergi, Medalia, Ohad, Geiger, Benjamin, Gräter, Frauke

“…The talin-vinculin axis is a key mechanosensing component of cellular focal adhesions. How talin and vinculin respond to forces and regulate one another…”
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Structural Analysis of Supramolecular Assemblies by Cryo-Electron Tomography by Harapin, Jan, Eibauer, Matthias, Medalia, Ohad

“…Structural analysis of macromolecular assemblies in their physiological environment is a challenging task that is instrumental in answering fundamental…”
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Cellular and Structural Studies of Eukaryotic Cells by Cryo-Electron Tomography by Weber, Miriam Sarah, Wojtynek, Matthias, Medalia, Ohad

“…The architecture of protein assemblies and their remodeling during physiological processes is fundamental to cells. Therefore, providing high-resolution…”
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Architecture and Characteristics of Bacterial Nanotubes by Dubey, Gyanendra P., Malli Mohan, Ganesh Babu, Dubrovsky, Anna, Amen, Triana, Tsipshtein, Shai, Rouvinski, Alex, Rosenberg, Alex, Kaganovich, Daniel, Sherman, Eilon, Medalia, Ohad, Ben-Yehuda, Sigal

“…Bacteria display an array of contact-dependent interaction systems that have evolved to facilitate direct cell-to-cell communication. We have previously…”
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The ABC exporter IrtAB imports and reduces mycobacterial siderophores by Arnold, Fabian M., Weber, Miriam S., Gonda, Imre, Gallenito, Marc J., Adenau, Sophia, Egloff, Pascal, Zimmermann, Iwan, Hutter, Cedric A. J., Hürlimann, Lea M., Peters, Eike E., Piel, Jörn, Meloni, Gabriele, Medalia, Ohad, Seeger, Markus A.

“…Intracellular replication of the deadly pathogen Mycobacterium tuberculosis relies on the production of small organic molecules called siderophores that…”
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Nanosecond chain dynamics of single-stranded nucleic acids by Nüesch, Mark F., Pietrek, Lisa, Holmstrom, Erik D., Nettels, Daniel, von Roten, Valentin, Kronenberg-Tenga, Rafael, Medalia, Ohad, Hummer, Gerhard, Schuler, Benjamin

“…The conformational dynamics of single-stranded nucleic acids are fundamental for nucleic acid folding and function. However, their elementary chain dynamics…”
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Snapshots of nuclear pore complexes in action captured by cryo-electron tomography by Baumeister, Wolfgang, Medalia, Ohad, Beck, Martin, Lu i, Vladan, Förster, Friedrich

“…Nuclear pore complexes reside in the nuclear envelope of eukaryotic cells and mediate the nucleocytoplasmic exchange of macromolecules. Traffic is regulated by…”
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