Search Results - "Mechti, Nadir"

Interferon-inducible ribonuclease ISG20 inhibits hepatitis B virus replication through directly binding to the epsilon stem-loop structure of viral RNA by Liu, Yuanjie, Nie, Hui, Mao, Richeng, Mitra, Bidisha, Cai, Dawei, Yan, Ran, Guo, Ju-Tao, Block, Timothy M, Mechti, Nadir, Guo, Haitao

“…Hepatitis B virus (HBV) replicates its DNA genome through reverse transcription of a viral RNA pregenome. We report herein that the interferon (IFN) stimulated…”
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TRIM22 Inhibits Influenza A Virus Infection by Targeting the Viral Nucleoprotein for Degradation by Di Pietro, Andrea, Kajaste-Rudnitski, Anna, Oteiza, Alexandra, Nicora, Lucia, Towers, Greg J, Mechti, Nadir, Vicenzi, Elisa

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The Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax Controls Forkhead Box O4 Activity through Degradation by the Proteasome by OTEIZA, Alexandra, MECHTI, Nadir

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TRIM22 Inhibits HIV-1 Transcription Independently of Its E3 Ubiquitin Ligase Activity, Tat, and NF-κB-Responsive Long Terminal Repeat Elements by Kajaste-Rudnitski, Anna, Marelli, Sara S., Pultrone, Cinzia, Pertel, Thomas, Uchil, Pradeep D., Mechti, Nadir, Mothes, Walther, Poli, Guido, Luban, Jeremy, Vicenzi, Elisa

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TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus by Eldin, Patrick, Papon, Laura, Oteiza, Alexandra, Brocchi, Emiliana, Lawson, T. Glen, Mechti, Nadir

“…1 Université Montpellier 1, Centre d'études d'agents Pathogènes et Biotechnologies pour la Santé (CPBS), Montpellier, France 2 CNRS, UMR 5236, CPBS, 4 Bd Henri…”
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ISG20, an actor of the innate immune response by Degols, Genevieve, Eldin, Patrick, Mechti, Nadir

“…The interferon (IFN) system is a major effector of the innate immunity that allows time for the subsequent establishment of an adaptive immune response against…”
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The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection by Papon, Laura, Oteiza, Alexandra, Imaizumi, Tadaatsu, Kato, Hiroki, Brocchi, Emiliana, Lawson, T. Glen, Akira, Shizuo, Mechti, Nadir

“…Abstract RNA helicase-like receptors MDA-5 but not RIG-I has been shown to be essential for triggering innate immune responses against picornaviruses. However,…”
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Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009 by Pagani, Isabel, Di Pietro, Andrea, Oteiza, Alexandra, Ghitti, Michela, Mechti, Nadir, Naffakh, Nadia, Vicenzi, Elisa

“…Influenza A viruses (IAVs) can cause zoonotic infections with pandemic potential when most of the human population is immunologically naive. After a pandemic,…”
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ISG20, a New Interferon-induced RNase Specific for Single-stranded RNA, Defines an Alternative Antiviral Pathway against RNA Genomic Viruses by Espert, Lucile, Degols, Genevieve, Gongora, Celine, Blondel, Danielle, Williams, Bryan R., Silverman, Robert H., Mechti, Nadir

“…Interferons (IFNs) encode a family of secreted proteins that provide the front-line defense against viral infections. Their diverse biological actions are…”
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Interferon-induced exonuclease ISG20 exhibits an antiviral activity against human immunodeficiency virus type 1 by Espert, Lucile, Degols, Genevieve, Lin, Yea-Lih, Vincent, Thierry, Benkirane, Monsef, Mechti, Nadir

“…1 CNRS, UMR-5160, EFS, 240 avenue Emile Jeanbrau, 34094 Montpellier Cedex 5, France 2 Institut de Genetique Humaine, CNRS, UPR-1142, 141 rue de la Cardonille,…”
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Extracellular matrix in bone marrow can mediate drug resistance in myeloma by Vincent, Thierry, Mechti, Nadir

“…Glucocorticoids such as dexamethasone, frequently used for the treatment of multiple myeloma (MM), produce a rapid reduction in tumor mass. However, despite…”
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Molecular Cloning of a New Interferon-induced Factor That Represses Human Immunodeficiency Virus Type 1 Long Terminal Repeat Expression (∗) by Tissot, Catherine, Mechti, Nadir

“…Transcriptional induction of genes is an essential part of the cellular response to interferons. To isolate yet unidentified IFN-regulated genes we have…”
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Polyinosinic-polycytidylic acid induces the expression of interferon-stimulated gene 20 in mesangial cells by Imaizumi, Tadaatsu, Tanaka, Hiroshi, Mechti, Nadir, Matsumiya, Tomoh, Yoshida, Hidemi, Sato, Fuyuki, Aizawa-Yashiro, Tomomi, Tsuruga, Kazushi, Hayakari, Ryo, Satoh, Kei

“…Interferon (IFN)-stimulated gene 20 (ISG20) is a 3'-to-5' exonuclease specific for single-stranded RNA and involved in host defense reactions against RNA…”
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FoxO4 negatively controls Tat-mediated HIV-1 transcription through the post-transcriptional suppression of Tat encoding mRNA by Oteiza, Alexandra, Mechti, Nadir

“…The connection between the repression of human immunodeficiency virus type 1(HIV-1) transcription and the resting CD4+ T cell state suggests that the host…”
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The exonuclease ISG20 is directly induced by synthetic dsRNA via NF-κB and IRF1 activation by ESPERT, Lucile, REY, Clémence, GONZALEZ, Laure, DEGOLS, Geneviève, CHELBI-ALIX, Mounira Kmar, MECHTI, Nadir, GONGORA, Céline

“…Many interferon (IFN)-stimulated genes are also induced by double-stranded RNA (dsRNA), a component closely associated with the IFN system in the context of…”
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Expression of interferon-stimulated gene 20 in vascular endothelial cells by Imaizumi, Tadaatsu, Mechti, Nadir, Matsumiya, Tomoh, Sakaki, Hirotaka, Kubota, Kosei, Yoshida, Hidemi, Kimura, Hiroto, Satoh, Kei

“…ABSTRACT ISG20 is an ribonuclease specific for single‐stranded RNA and considered to play a role in innate immunity against virus infections. We herein show…”
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Molecular Cloning of a New Interferon-induced PML Nuclear Body-associated Protein by Gongora, Celine, David, Gregory, Pintard, Lionel, Tissot, Catherine, Hua, The Duc, Dejean, Anne, Mechti, Nadir

“…Transcriptional induction of genes is an essential part of the cellular response to interferons. We have established a cDNA library from human lymphoblastoid…”
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Hyaluronic Acid Induces Survival and Proliferation of Human Myeloma Cells through an Interleukin-6-mediated Pathway Involving the Phosphorylation of Retinoblastoma Protein by Vincent, Thierry, Jourdan, Michel, Sy, Man-Sun, Klein, Bernard, Mechti, Nadir

“…Originating from a post-switch memory B cell or plasma cell compartment in peripheral lymphoid tissues, malignant myeloma cells accumulate in the bone marrow…”
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Control of FoxO4 Activity and Cell Survival by TRIM22 Directs TLR3-Stimulated Cells Toward IFN Type I Gene Induction or Apoptosis by Oteiza, Alexandra, Mechti, Nadir

“…Activation of innate immune response, induced after the recognition of double-stranded RNA (dsRNA), formed during replication of most viruses, results in…”
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Altered Memory Capacities and Response to Stress in p300 CBP-Associated Factor (PCAF) Histone Acetylase Knockout Mice by MAURICE, Tangui, DUCLOT, Florian, OZATO, Keiko, GONGORA, Céline, MEUNIER, Johann, NAERT, Gaëlle, GIVALOIS, Laurent, MEFFRE, Julie, CELERIER, Aurélie, JACQUET, Chantal, COPOIS, Virginie, MECHTI, Nadir

“…Chromatin remodeling by posttranslational modification of histones plays an important role in brain plasticity, including memory, response to stress and…”
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