An Automated, Highly Selective Reaction Monitoring Instrument Using Molecular Rotational Resonance Spectroscopy

Online monitoring of chemical reactions by using analytical chemistry tools is a powerful way to maximize control over these processes. In this paper, we demonstrate the use of molecular rotational resonance, an emerging and extraordinarily selective spectroscopic technique, to perform automated rea...

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Bibliographic Details
Published in:	Precision Chemistry Vol. 2; no. 2; pp. 57 - 62
Main Authors:	Byars, Ann Adele, Kompally, Khushi R., Mechnick, Emily, Sonstrom, Reilly E., Mikhonin, Alexander, Neill, Justin L., Boetzel, Ruth, MacGregor, James, Talicska, Courtney, Li, Jian, Liu, Yizhou
Format:	Journal Article
Language:	English
Published:	United States University of Science and Technology of China and American Chemical Society 26-02-2024 American Chemical Society
Subjects:	Letter reaction monitoring reaction kinetics process analytical technology molecular rotational resonance spectroscopy isotopes
Online Access:	Get full text
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Summary:	Online monitoring of chemical reactions by using analytical chemistry tools is a powerful way to maximize control over these processes. In this paper, we demonstrate the use of molecular rotational resonance, an emerging and extraordinarily selective spectroscopic technique, to perform automated reaction monitoring measurements. An interface using a six-port valve with a calibrated sample loop, coupled to a temperature controlled inlet for analyte volatilization, was developed and tested. Two reactions were chosen for initial characterization: an amine-aldehyde condensation reaction to form an imine product and an isotopic exchange reaction of a β-ketoester with keto–enol tautomerization. The spectrometer was able to provide kinetic information about the reaction and determine reaction completion. In the future, this system can be extended to detect and quantify impurities and characterize reaction selectivity, in addition to the reaction progress.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2771-9316 2771-9316
DOI:	10.1021/prechem.3c00098