Search Results - "Mechlovich, Danit"

The novel multitarget iron chelating and propargylamine drug M30 affects APP regulation and processing activities in Alzheimer's disease models by Amit, Tamar, Bar-Am, Orit, Mechlovich, Danit, Kupershmidt, Lana, Youdim, Moussa B.H., Weinreb, Orly

“…In many of the neurodegenerative diseases, such as Alzheimer's disease (AD) and AD-related disorders, as well as in the regular ageing process, excessive…”
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Neuroprotective and neurorestorative activities of a novel iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in animal models of Parkinson's disease and aging by Bar-Am, Orit, Amit, Tamar, Kupershmidt, Lana, Aluf, Yuval, Mechlovich, Danit, Kabha, Hoda, Danovitch, Lena, Zurawski, Vincent R, Youdim, Moussa B.H, Weinreb, Orly

“…Abstract Recently, we have designed and synthesized a novel multipotent, brain-permeable iron-chelating drug, VAR10303 (VAR), possessing both propargyl and…”
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Creation of a gene expression classifier for predicting Parkinson’s disease rate of progression by Rabey, Jose Martin, Yarden, Jennifer, Dotan, Nir, Mechlovich, Danit, Riederer, Peter, Youdim, Moussa B. H.

“…Parkinson’s disease (PD) etiology is heterogeneous, genetic, and multi-factorial, resulting in a varied disease from a mild slow progression to a more severe…”
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Molecular targets of the multifunctional iron‐chelating drug, M30, in the brains of mouse models of type 2 diabetes mellitus by Mechlovich, Danit, Amit, Tamar, Bar‐Am, Orit, Weinreb, Orly, Youdim, Moussa B H

“…Background and Purpose Neurodegenerative diseases are now recognized to be multifunctional, whereby a heterogeneous set of reactions acts independently or…”
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Molecular targets of the multifunctional iron‐chelating drug, M 30, in the brains of mouse models of type 2 diabetes mellitus by Mechlovich, Danit, Amit, Tamar, Bar‐Am, Orit, Weinreb, Orly, Youdim, Moussa B H

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The novel multi-target iron chelator, M30 modulates HIF-1α-related glycolytic genes and insulin signaling pathway in the frontal cortex of APP/PS1 Alzheimer's disease mice by Mechlovich, Danit, Amit, Tamar, Bar-Am, Orit, Mandel, Silvia, Youdim, Moussa B H, Weinreb, Orly

“…Increasing evidence suggests that dysregulation of brain insulin/insulin receptor (InsR) and insulin signaling cascade are associated with the pathogenesis of…”
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The novel multifunctional, iron-chelating drugs M30 and HLA20 protect pancreatic beta-cell lines from oxidative stress damage by Mechlovich, Danit, Amit, Tamar, Mandel, Silvia A, Bar-Am, Orit, Bloch, Konstantin, Vardi, Pnina, Youdim, Moussa B H

“…Increasing evidence suggests that oxidative stress (OS)-induced pancreatic beta-cell impairments is involved in diabetes and diabetic complications. Our group…”
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Effects of novel neuroprotective and neurorestorative multifunctional drugs on iron chelation and glucose metabolism by Pollak, Yulia, Mechlovich, Danit, Amit, Tamar, Bar-Am, Orit, Manov, Irena, Mandel, Silvia A., Weinreb, Orly, Meyron-Holtz, Esther G., Iancu, Theodore C., Youdim, Moussa B. H.

“…Iron accumulation and iron-related oxidative stress are involved in several pathological conditions and provide a rationale for the development of iron…”
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